Dan Shen Yin

Salvia Decoction · 丹參飲

Also known as: Salvia Drink, Dan Shen Drink

A simple three-herb formula used to relieve chest and stomach pain caused by poor blood circulation and stagnant Qi. It works by promoting blood flow and easing Qi movement in the chest and abdomen. The source text notes it is especially effective for women.

Origin Shí Fāng Gē Kuò (时方歌括, Collected Songs on Modern Formulas) by Chén Niàn-Zǔ (Chen Xiu-Yuan) — Qīng dynasty, 1801 CE
Composition 3 herbs
Dan Shen
King
Dan Shen
Tan Xiang
Assistant
Tan Xiang
Sha Ren
Assistant
Sha Ren
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dan Shen Yin is designed to correct these specific patterns.

Why Dan Shen Yin addresses this pattern

Dan Shen Yin directly targets the combined pattern of Qi stagnation and Blood stasis in the Middle and Upper Burners. When Qi becomes stuck and Blood flow slows, this creates a self-reinforcing cycle: stagnant Qi fails to push Blood forward, and stagnant Blood physically blocks the channels, further impeding Qi flow. This produces fixed, stabbing, or boring pain in the chest and epigastrium that worsens under pressure. Dan Shen powerfully breaks through Blood stasis while Tan Xiang and Sha Ren restore the smooth movement of Qi, addressing both halves of the pathological cycle simultaneously.

A practitioner would look for one or more of these signs

Epigastric Pain Relieved With Pressure Or Eating

Stabbing or boring quality, fixed location, often worse after eating

Chest Pain

Oppressive pain with a sense of fullness or tightness

Abdominal Pain

Pain that resists pressure (refuses palpation)

Dark Complexion

Dull or purplish hue to lips or face

Amenorrhea

Menstrual pain with dark, clotted blood, especially in women

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Dan Shen Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, angina pectoris falls under the category of "chest impediment" (xiong bi, 胸痹) and "Heart pain" (xin tong, 心痛). The underlying mechanism involves obstruction of the Heart vessels by Blood stasis, often accompanied by Qi stagnation or Phlegm. When Qi and Blood cannot flow freely through the chest, the Heart is deprived of nourishment, causing squeezing or stabbing chest pain. Contributing factors may include emotional stress (which knots Qi), poor diet, aging, or constitutional weakness. The pattern relevant to Dan Shen Yin is primarily one of Qi stagnation with Blood stasis rather than a Cold or Phlegm dominant pattern.

Why Dan Shen Yin Helps

Dan Shen, the King herb, has a strong affinity for the Heart channel and is one of the most commonly used herbs for Blood stasis in the Heart vessels. It invigorates Blood circulation and clears the channels. Modern research has demonstrated that Dan Shen Yin can reduce myocardial infarction size and lower inflammatory markers in experimental models. Tan Xiang specifically opens Qi stagnation in the chest, helping to relieve the tight, oppressive sensation. Sha Ren assists by moving Qi in the Middle Burner, ensuring that the overall Qi dynamic supports healthy circulation. Clinical studies have shown Dan Shen Yin to be effective for coronary heart disease with angina.

Also commonly used for

Peptic Ulcer

Gastric or duodenal ulcer pain with Blood stasis features

Chest Pain

Chest oppression and pain (xiong bi / chest impediment)

Hepatitis

Hypochondriac pain with Blood stasis entering the collaterals

Cholecystitis

Gallbladder inflammation with Qi and Blood stagnation

Pancreatitis

Abdominal pain due to Qi and Blood stagnation in the Middle Burner

What This Formula Does

Every TCM formula has a specific set of actions — here's what Dan Shen Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Dan Shen Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Dan Shen Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Dan Shen Yin works at the root level.

Dan Shen Yin addresses a pattern of combined Qi stagnation and Blood stasis in the chest and upper abdomen, centered on the Heart and Stomach. In TCM theory, when emotional stress, dietary irregularity, or chronic illness causes Qi to stop flowing smoothly in the Middle Burner (the digestive center), Blood circulation also becomes obstructed — because Blood relies on Qi to propel it through the vessels. The classical teaching is: "where Qi goes, Blood follows; when Qi stagnates, Blood congeals."

In the early stages, Qi becomes knotted in the channels of the chest and epigastric region, producing a sensation of distension, fullness, and dull aching. Over time, as the renowned Qing-dynasty physician Ye Tianshi observed, "prolonged pain enters the collateral vessels" (久痛入络). The initially functional Qi stagnation gives rise to physical Blood stasis, with pain becoming more fixed, stabbing, and worsened by pressure. The Stomach, which normally descends Qi to digest food, loses its natural downward movement, leading to poor appetite and possible nausea. Because the Heart governs Blood circulation and shares the upper chest space, this stagnation can simultaneously manifest as chest tightness and cardiac-region pain. Women are said to be especially susceptible to this pattern because of the close relationship between Qi-Blood regulation and the menstrual cycle.

Dan Shen Yin works by directly invigorating Blood circulation to break up the stasis while simultaneously moving Qi to relieve the underlying stagnation that caused the Blood to congeal. By addressing both Qi and Blood simultaneously, it unblocks the channels so that "when flow is unimpeded, there is no pain" (通则不痛).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly bitter and acrid (pungent) — bitter from Dan Shen to cool and move Blood, acrid from Tan Xiang and Sha Ren to warm, disperse, and move Qi.

Target Organs

Ingredients

3 herbs

The herbs that make up Dan Shen Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Dan Shen

Dan Shen

Red sage roots

Dosage 15 - 30g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Liver

Role in Dan Shen Yin

The principal herb, used in a dose five to ten times that of the other two ingredients. Dan Shen enters the Heart and Liver channels, powerfully invigorates Blood, dispels Blood stasis, and alleviates pain. It directly addresses the core pathomechanism of Blood stagnation in the Heart and Stomach.
Assistants — Supports or moderates other herbs
Tan Xiang

Tan Xiang

Sandalwood

Dosage 3 - 5g
Temperature Warm
Taste Pungent
Organ Affinity Spleen, Stomach, Heart, Lungs
Preparation Add in last 5-10 minutes of decoction (后下) to preserve aromatic oils

Role in Dan Shen Yin

Warms the Middle Burner, promotes Qi movement, and relieves pain in the chest and epigastrium. Since Blood circulation depends on the smooth flow of Qi, Tan Xiang supports Dan Shen by ensuring Qi moves freely so Blood can follow.
Sha Ren

Sha Ren

Amomum fruits

Dosage 3 - 5g
Temperature Warm
Taste Pungent
Organ Affinity Kidneys, Spleen, Stomach
Preparation Add in last 5 minutes of decoction (后下) to preserve aromatic oils

Role in Dan Shen Yin

Moves Qi, warms the Middle Burner, loosens the chest, and harmonizes the Stomach. Works alongside Tan Xiang to address the Qi stagnation component, and also helps the Stomach receive and transform food, addressing the symptom of poor appetite or pain aggravated by eating.

Why This Combination Works

How the herbs in Dan Shen Yin complement each other

Overall strategy

This formula addresses the intertwined pathology of Blood stasis and Qi stagnation in the chest and epigastrium. Its design follows a simple but elegant principle: move Blood as the primary action and regulate Qi as the supporting action, since Blood relies on Qi to circulate and stagnant Qi will perpetuate Blood stasis.

King herbs

Dan Shen (Salvia Root) is used at a dose five to ten times that of the other herbs, making its role as the King unmistakable. It enters the Heart and Liver Blood level, powerfully invigorating Blood and dispelling stasis. Its slightly cold nature also gently clears any Heat that may have accumulated from long-standing stagnation. A classical saying holds that "one herb, Dan Shen, has the function of Si Wu Tang (Four Substance Decoction)," underscoring its comprehensive Blood-moving capacity.

Assistant herbs

Tan Xiang (Sandalwood) and Sha Ren (Amomum Fruit) serve as a reinforcing pair that addresses the Qi stagnation dimension. Tan Xiang is warm and aromatic, specializing in opening Qi stagnation in the chest and epigastrium. Sha Ren warms the Middle Burner, moves Qi, and harmonizes the Stomach. Together they ensure that Qi flows freely, which in turn supports Dan Shen's Blood-moving action. Their warm nature also balances Dan Shen's slightly cold property, preventing it from congealing the very Blood it is meant to move.

Notable synergies

The core synergy is between the single Blood-level herb (Dan Shen) and the two Qi-level herbs (Tan Xiang and Sha Ren). This creates a formula that treats both Qi and Blood simultaneously from a very lean ingredient list. The original compiler Chen Xiu-Yuan praised this formula simply as "稳" (steady/reliable), emphasizing its well-balanced, safe design despite having only three ingredients. The warm, aromatic quality of Tan Xiang and Sha Ren also counterbalances Dan Shen's cool nature, making the formula gentle enough for prolonged use.

How to Prepare

Traditional preparation instructions for Dan Shen Yin

Decoct all three herbs together in approximately 330 ml (one and a half cups) of water. Reduce to about 230 ml (about seven-tenths of the original volume) over moderate heat. Strain and take warm as a single dose. The original text specifies: "水一杯半,煎七分服" (one and a half cups of water, decocted to seven-tenths and taken). Administer twice daily.

Tan Xiang (Sandalwood) is aromatic and should ideally be added near the end of cooking (last 5-10 minutes) to preserve its volatile oils, though the original source does not specify this. Sha Ren (Amomum) is similarly aromatic and benefits from being added in the final minutes of decoction.

Common Modifications

How practitioners adapt Dan Shen Yin for specific situations

Added
Yu Jin

9-12g, invigorates Blood and moves Qi to enhance pain relief

Ru Xiang

3-6g, activates Blood and alleviates pain, particularly for fixed stabbing pain

When pain is severe and Blood stasis is pronounced, Yu Jin and Ru Xiang reinforce Dan Shen's stasis-dispelling action. The noted physician Qin Bo-Wei recommended adding Yu Jin and Ru Xiang for severe epigastric pain.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Dan Shen Yin should not be used or requires extra caution

Avoid

Pregnancy. Dan Shen (Salvia miltiorrhiza) is a Blood-invigorating herb that can stimulate uterine activity and carries risk of promoting bleeding.

Avoid

Active hemorrhagic disorders or bleeding diathesis. The formula's Blood-moving action may worsen any active bleeding condition.

Avoid

Concurrent anticoagulant therapy (especially warfarin). Dan Shen has well-documented pharmacokinetic and pharmacodynamic interactions with warfarin that can cause dangerous over-anticoagulation.

Caution

Patients without Blood Stasis. This formula is designed for pain caused by Qi stagnation and Blood stasis. It should not be used for pain due to deficiency patterns, as its moving and dispersing nature could deplete a patient who is already weak.

Caution

Yin-deficiency or Blood-deficiency Heat patterns with no Stasis. Although Dan Shen has some mild cooling and Blood-nourishing properties, the formula as a whole is focused on moving, not supplementing.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Dan Shen (Salvia miltiorrhiza), the chief ingredient making up the majority of this formula, is a potent Blood-invigorating herb that can stimulate uterine contractions and promote bleeding. Classical sources note it can "落死胎" (expel a dead fetus), indicating recognized abortifacient potential. Both Sha Ren and Tan Xiang are Qi-moving herbs that further increase the formula's dispersing nature. Pregnant women should avoid this formula entirely.

Breastfeeding

No specific classical prohibitions exist for use during breastfeeding, and the formula contains no known toxic substances. However, Dan Shen's active compounds (tanshinones and salvianolic acids) are pharmacologically potent and could theoretically pass into breast milk. Given the Blood-moving nature of the formula, it should be used with caution during the postpartum period and only under professional guidance. If there is no active Blood stasis condition requiring treatment, it is best avoided while nursing.

Children

Dan Shen Yin is not a standard pediatric formula. The pattern it treats — Qi stagnation with Blood stasis causing epigastric or chest pain — is relatively uncommon in young children. If used in adolescents for appropriate indications (such as menstrual pain with Blood stasis), doses should be reduced to approximately one-third to one-half of the adult dose, adjusted by the child's age and body weight. A qualified practitioner should always supervise use in minors. This formula should generally not be used in children under 6 years of age.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Dan Shen Yin

Warfarin and other anticoagulants: This is the most important and well-documented interaction. Dan Shen (Salvia miltiorrhiza), the chief herb in this formula, significantly potentiates warfarin's anticoagulant effect through both pharmacokinetic mechanisms (increasing warfarin absorption, AUC, and half-life while decreasing clearance) and pharmacodynamic mechanisms (inherent antiplatelet and fibrinolytic activity). Multiple published case reports describe life-threatening bleeding complications including hemothorax when danshen was taken with warfarin. This combination should be strictly avoided.

Antiplatelet agents (aspirin, clopidogrel): Dan Shen inhibits platelet aggregation independently and may increase bleeding risk when combined with antiplatelet drugs. Research has also shown that Danshen preparations can alter clopidogrel's pharmacokinetics by inducing CYP enzymes. Use with caution and under medical supervision only.

Digoxin: Dan Shen may interfere with serum digoxin measurement assays, potentially leading to inaccurate monitoring results. This analytical interference could lead to inappropriate dose adjustments.

Drugs metabolized by CYP3A4: Tanshinones from Dan Shen have been shown to modulate cytochrome P450 enzymes, particularly CYP3A4. This could theoretically affect the metabolism of a wide range of pharmaceutical drugs processed by this pathway.

Usage Guidance

Practical advice for getting the most out of Dan Shen Yin

Best time to take

30 minutes before meals, twice daily (morning and evening), to optimize absorption and direct the formula's action to the Stomach and Middle Burner.

Typical duration

Acute pain episodes: 3–7 days. Chronic Qi stagnation and Blood stasis patterns (e.g. recurring epigastric pain, angina): 2–4 weeks, then reassessed by a practitioner.

Dietary advice

While taking this formula, avoid cold and raw foods, icy drinks, and excessive greasy or heavy foods that may impair Qi circulation and worsen epigastric stagnation. Favor lightly cooked, warm meals that are easy to digest. Avoid alcohol in excess, as it generates Heat and can interact with the Blood-moving properties of the formula. Foods that gently support circulation, such as small amounts of hawthorn fruit, turmeric in cooking, or black vinegar, may complement the formula's action. If being used for Stomach pain, eat at regular times and in moderate portions — irregular eating habits contribute to Qi stagnation in the Middle Burner.

Dan Shen Yin originates from Shí Fāng Gē Kuò (时方歌括, Collected Songs on Modern Formulas) by Chén Niàn-Zǔ (Chen Xiu-Yuan) Qīng dynasty, 1801 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Dan Shen Yin and its clinical use

From the Shi Fang Ge Kuo (《时方歌括》, Compendium of Songs on Modern Formulas) by Chen Xiu-Yuan:

「治心痛胃脘诸痛多效。妇人更效。心腹诸疼有妙方,丹参十分作提纲。檀砂一分聊为佐,入咽咸知效验彰。丹参一两,檀香砂仁各一钱,水一杯半,煎七分服。」

Translation: "Treats Heart pain and all Stomach-duct pains with much effectiveness. Especially effective for women. For all Heart and abdominal pains there is a marvellous formula: Dan Shen in ten parts takes the lead. Tan Xiang and Sha Ren in one part each serve as assistants. Once swallowed, all will know its proven efficacy. Dan Shen one liang; Tan Xiang and Sha Ren each one qian. Water one and a half cups, decoct to seven-tenths and take."

Chen Xiu-Yuan's own commentary on this formula was a single word: 「稳」 — meaning "steady" or "reliable" — a succinct endorsement of its safety and dependability.

Historical Context

How Dan Shen Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Dan Shen Yin was recorded in the Shi Fang Ge Kuo (《时方歌括》, Compendium of Songs on Modern Formulas), published in 1801 during the Qing Dynasty by the physician-scholar Chen Xiu-Yuan (陈修园, also known as Chen Nian-Zu). Chen was famous for making classical medicine accessible through memorable verse, and this formula is a prime example of his pedagogical style — the prescription and its rationale are presented as a rhyming song for easy memorization by students.

The formula is remarkably simple, containing only three herbs, yet Chen praised it with the single-character commentary "稳" (stable, reliable). This brevity of endorsement was characteristic of his no-nonsense approach. The formula is classified under the heading "滑可去着" ("the slippery can remove what is stuck"), referring to the therapeutic principle that smooth, moving substances can dislodge pathological stagnation. Despite its simplicity, Dan Shen Yin has become one of the most frequently combined base formulas in modern Chinese clinical practice. It is commonly paired with Jin Ling Zi San for intensified pain relief, with Ban Xia Xie Xin Tang for gastric conditions with mixed Heat and Cold, or with Gua Lou Xie Bai formulas for chest pain with Phlegm obstruction. Its modern prominence in cardiology reflects its adaptation from treating the traditional category of "Heart and Stomach pain" to the biomedical context of angina pectoris and coronary artery disease.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Dan Shen Yin

1

Dan-Shen-Yin protects the heart against inflammation and oxidative stress induced by acute ischemic myocardial injury in rats (Preclinical study, 2012)

Liang JQ, Wu K, Jia ZH, et al. Experimental and Therapeutic Medicine, 2012, 4(5), 917-922.

In a rat model of acute myocardial ischemia induced by coronary artery ligation, oral Dan Shen Yin significantly reduced infarction size and lowered serum levels of inflammatory markers (C-reactive protein, interleukin-6, TNF-alpha) and oxidative stress markers (malondialdehyde), while increasing protective antioxidant enzyme activity (superoxide dismutase and glutathione). The study suggests that DSY's cardioprotective effects work through both anti-inflammatory and antioxidant pathways.

PubMed
2

Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis (Preclinical/computational study, 2022)

Zhang Y, Zheng P, Wu G, et al. Frontiers in Pharmacology, 2022, 13, 946193.

This study used network pharmacology combined with cell experiments to investigate how Dan Shen Yin might counteract atherosclerosis by inhibiting endothelial-to-mesenchymal transition (EndMT), a process where vessel-lining cells transform into scar-forming cells that worsen plaque formation. The analysis identified multiple molecular targets and signaling pathways through which DSY's active compounds may exert anti-atherosclerotic effects.

3

Dan-shen Yin attenuates myocardial fibrosis after myocardial infarction in rats: Molecular mechanism insights by integrated transcriptomics and network pharmacology analysis and experimental validation (Preclinical study, 2025)

Journal of Ethnopharmacology, 2025 (published online Nov 2024).

Using a rat model of myocardial infarction with post-infarction fibrosis (scarring of the heart muscle), this study found that Dan Shen Yin could reduce myocardial fibrosis. Researchers used transcriptomics and network pharmacology to identify the underlying signaling pathways responsible for this effect.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.