Formula

Zhi Gan Cao Tang

Prepared Licorice Combination | 炙甘草汤

Also known as:

Fu Mai Tang (復脈湯, Restore the Pulse Decoction)

Properties

Qi and Blood tonifying formulas · Slightly Warm

Key Ingredients

Gan Cao, Shu Di huang

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula used to nourish the Heart by replenishing both Qi and Blood while gently warming Heart Yang. It is primarily used for people experiencing palpitations, irregular heartbeat, fatigue, and shortness of breath caused by depletion of the body's vital substances. Because it simultaneously supports Yin, Yang, Qi, and Blood, it is one of the most balanced restorative formulas in Chinese medicine.

Formula Category

Main Actions

  • Nourishes Yin and Blood
  • Tonifies Qi
  • Warms and unblocks Yang
  • Restores the pulse
  • Calms palpitations
  • Moistens Dryness

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhi Gancao Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Zhi Gancao Tang addresses this pattern

This is the primary pattern treated by Zhi Gan Cao Tang. When both Qi and Yin of the Heart are depleted, the heart vessels become empty and the Heart lacks the driving force and nourishment to maintain a steady rhythm. The Qi deficiency means there is not enough motive power to push Blood through the vessels consistently, while the Yin and Blood deficiency means the vessels themselves are insufficiently filled. The result is an irregular pulse that skips beats (the classical 'knotted' or 'intermittent' pulse) and palpitations felt as the Heart struggles to compensate.

The formula addresses this through its dual Kings: Zhi Gan Cao and Ren Shen boost Heart and Spleen Qi, providing the motive force, while Sheng Di Huang, E Jiao, Mai Men Dong, and Huo Ma Ren deeply nourish Heart Yin and Blood, refilling the vessels. Gui Zhi and Sheng Jiang gently warm Heart Yang to keep the newly generated Blood moving. This comprehensive approach simultaneously restores the substance, the warmth, and the Qi that the Heart needs to beat regularly.

A practitioner would look for one or more of these signs

Palpitations

Heart palpitations, felt as irregular or forceful heartbeat

Irregular Pulse

Knotted pulse (jie mai) or intermittent pulse (dai mai) that skips beats

Shortness Of Breath

Shortness of breath, especially on exertion

Eye Fatigue

General weakness and emaciation

Insomnia

Restless sleep due to Heart being unnourished

Spontaneous Sweat

Spontaneous sweating or night sweats

Dry Mouth

Dry mouth and throat

Constipation

Dry stools from fluid depletion

How It Addresses the Root Cause

The core disease mechanism addressed by Zhi Gan Cao Tang is a dual deficiency of both Yin-Blood and Yang-Qi in the Heart system. In TCM, the Heart governs the blood vessels and relies on adequate Blood and Yin to fill the vessels, and sufficient Qi and Yang to propel Blood through them. When both sides are deficient, the Heart loses its nourishment and its driving force simultaneously.

This pattern often arises after prolonged illness, excessive sweating, vomiting, or purging (as described in the Shang Han Lun context), or from chronic consumptive conditions that gradually exhaust the body's reserves. When Yin and Blood are insufficient, the blood vessels cannot be fully filled. When Yang and Qi are also weak, there is not enough force to push blood forward in a steady rhythm. The result is a pulse that intermittently skips or pauses (called "knotted" or "intermittent" in TCM pulse diagnosis), corresponding to what modern medicine recognizes as cardiac arrhythmia. The Heart muscle itself, deprived of nourishment, produces the subjective sensation of palpitations: an uncomfortable, anxious awareness of one's own heartbeat.

Because the Spleen is the source of Qi and Blood production, and the Kidneys are the root of Yin, the deficiency often extends beyond the Heart alone. The patient may appear thin, fatigued, and short of breath, with a dry tongue lacking coating. The condition represents a systemic depletion where the Heart is simply the organ most visibly affected.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly sweet and mildly pungent. The sweet taste from Gan Cao, Sheng Di Huang, Mai Men Dong, Da Zao, and Ren Shen dominates, serving to tonify Qi and nourish Yin-Blood. The mild pungency from Gui Zhi and Sheng Jiang provides the warming, circulating counterbalance.

Target Organs
Heart Spleen Lungs Kidneys
Channels Entered
Heart Spleen Lung Kidney

Formula Origin

Shang Han Lun (傷寒論) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Zhi Gan Cao Tang

Detailed information about each herb in Zhi Gan Cao Tang and their roles

Kings
Deputies
Assistants
Envoys
Gan Cao
Gan Cao

Liquorice

Dosage: 12 - 15g

Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Dried root and rhizome
Role in Zhi Gan Cao Tang

Used in a large dose as the chief herb that names the formula. It warms and supplements the Qi of the Middle Burner, opens the channels, moves the Blood, and calms the Heart. Its sweet and warm nature nourishes the Heart Qi and supports the generation of Qi and Blood from the Spleen.

Shu Di huang
Shu Di huang

Prepared rehmannia

Dosage: 30 - 50g

Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver
Parts Used Prepared dried root tuber
Role in Zhi Gan Cao Tang

Used in the heaviest dose in the entire formula (classically one jin, approximately 50g). It powerfully nourishes Yin and Blood, fills the blood vessels, and enriches the Heart. As the primary Yin-nourishing herb, it anchors the formula's ability to restore substance to depleted blood vessels and nourish the Heart body.

Ren Shen
Ren Shen

Ginseng

Dosage: 6 - 10g

Temperature Warm
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Spleen
Parts Used Dried root
Role in Zhi Gan Cao Tang

Powerfully tonifies the original Qi and strengthens the Spleen, providing the source for Qi and Blood generation. Works with Zhi Gan Cao to boost Heart Qi and calm the spirit, relieving palpitations and anxiety.

E Jiao
E Jiao

Donkey-hide gelatin

Dosage: 6 - 10g

Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver, Lungs
Parts Used Solid glue prepared from the dried or fresh skin of donkeys
Role in Zhi Gan Cao Tang

Nourishes Heart Blood and Yin, enriches the blood vessels, and moistens dryness. Its rich, viscous nature helps fill depleted blood vessels and works with Sheng Di Huang to restore Heart Yin and Blood.

Tian Men Dong
Tian Men Dong

Chinese asparagus tubers

Dosage: 10 - 15g

Temperature Cold
Taste Bitter, Sweet
Organ Affinity Kidneys, Lungs
Parts Used The dry tuber
Role in Zhi Gan Cao Tang

Nourishes Heart and Lung Yin, generates fluids, and clears deficiency irritability. Pairs with Sheng Di Huang to enrich Yin and moisten dryness throughout the upper and middle body.

Huo Ma Ren
Huo Ma Ren

Hemp seeds

Dosage: 10 - 15g

Temperature Neutral
Taste Sweet
Organ Affinity Large Intestine, Spleen, Stomach
Parts Used Dried ripe fruit
Role in Zhi Gan Cao Tang

Moistens and lubricates the blood vessels and intestines. Its oily nature helps nourish Yin and Blood, contributing to the overall enriching strategy. Also addresses the constipation that commonly accompanies this pattern of fluid depletion.

Gui Zhi
Gui Zhi

Cinnamon twigs

Dosage: 6 - 9g

Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Lungs, Spleen
Parts Used Dried young branches
Role in Zhi Gan Cao Tang

Warms Heart Yang and opens the blood vessels, ensuring that Qi and Blood can circulate. Paired with Zhi Gan Cao, it creates a 'sweet and acrid generating Yang' combination that revives Heart Yang. It also prevents the many rich, Yin-nourishing herbs from becoming stagnant and cloying.

Sheng Jiang
Sheng Jiang

Fresh ginger

Dosage: 9 - 10g

Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach
Parts Used Fresh root
Role in Zhi Gan Cao Tang

Warms the Middle Burner and promotes the movement of Qi through the channels. Works with Gui Zhi to warm Yang and open the vessels, ensuring the thick, nourishing herbs are properly distributed and do not cause stagnation.

Da Zao
Da Zao

Jujube dates

Dosage: 10 - 30 pieces

Temperature Warm
Taste Sweet
Organ Affinity Spleen, Stomach
Parts Used Dried ripe fruit
Role in Zhi Gan Cao Tang

Nourishes the Spleen, supplements Qi, and harmonizes the formula. Works with Ren Shen and Zhi Gan Cao to support the Spleen as the source of Qi and Blood production, and harmonizes the actions of the warming and nourishing ingredients.

Modern Research (4 studies)

  • Systematic Review of Randomized Controlled Trials: Zhigancao Decoction for Premature Ventricular Contractions (2015)
  • Protective Effects of Zhi-Gan-Cao-Tang Against Diabetic Myocardial Infarction Injury (2023, Preclinical)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Twice daily, morning and evening, taken warm on a relatively empty stomach (30-60 minutes before meals or 1-2 hours after meals) to optimize absorption of the rich tonic ingredients.

Typical Duration

Typically prescribed for 2-4 weeks for acute arrhythmia episodes, then reassessed. For chronic deficiency conditions, may be continued for 4-8 weeks with periodic review and dose adjustments.

Dietary Advice

Favor warm, easily digestible, nourishing foods that support Qi and Blood production: congee, soups, dates, longan fruit, cooked vegetables, and small amounts of lean protein. Avoid cold and raw foods, iced drinks, and excessive greasy or rich foods, as these can impair the Spleen's digestive function and hinder absorption of this heavily nourishing formula. Limit salty foods, as the high-dose Gan Cao already promotes sodium retention. Avoid excessive caffeine and stimulants, which can aggravate palpitations. The classical preparation includes rice wine for its warming, circulation-promoting properties; if not using wine in the decoction, a small amount of warm rice wine taken with the medicine may enhance its effects, but alcohol should be avoided by those with contraindications.

Modern Usage

Zhi Gan Cao Tang is an ancient Chinese herbal formula developed by Zhang Zhong Jing around 220 AD.

This formula is known for its nourishing properties and is primarily used to address Deficiencies in Qi and Blood, digestive issues, and overall fatigue. In TCM, it is commonly utilized to restore and regulate the pulse, nourish the Heart, and calm the Stomach.

In modern practice, it is frequently recommended for conditions such as chronic gastritis, arrhythmias, palpitations, adrenal insufficiency, low blood pressure, and fatigue. It is also valued for its role in supporting overall heart health.

Special Populations

Pregnancy

Use with caution during pregnancy. Gan Cao (licorice) in the high dose used in this formula (12g) has documented risks during pregnancy: glycyrrhizin may stimulate hypothalamic-pituitary-adrenal axis activity in the fetus and has been associated with increased risk of preterm delivery. E Jiao (donkey-hide gelatin) is generally considered safe in pregnancy, but Gui Zhi (cinnamon twig) is warm and activating, and the original preparation calls for rice wine, which should be omitted during pregnancy. The formula is not absolutely contraindicated but should only be used under professional supervision with dose adjustments, particularly reducing or removing the warming herbs and wine.

Breastfeeding

Caution is advised during breastfeeding. Gan Cao (licorice) is the primary concern: glycyrrhizin and its metabolites may transfer into breast milk, and their mineralocorticoid-like effects (sodium retention, potassium depletion) could theoretically affect the nursing infant. However, at standard decoction doses used short-term, clinically significant effects on the infant are not well documented. E Jiao and the other tonic herbs are generally considered compatible with breastfeeding. If the formula is needed, it should be used at moderate doses under practitioner supervision, with monitoring for any signs of fluid retention or electrolyte changes in the mother.

Pediatric Use

Zhi Gan Cao Tang can be used in children but requires careful dose adjustment. Pediatric doses should generally be reduced to one-third to one-half of the adult dose depending on age and body weight. For children under 6, doses should be further reduced. The formula's rich, cloying Yin-nourishing herbs (particularly Sheng Di Huang and E Jiao) can be difficult for immature digestive systems to tolerate, so the dose of these ingredients should be conservative. Gui Zhi and Sheng Jiang help counteract this but should also be proportionally adjusted. The rice wine component of the original preparation should be omitted for children. As with any tonifying formula, practitioners should ensure the child does not have concurrent Food Stagnation or Dampness before prescribing.

Drug Interactions

Digoxin (cardiac glycosides)

This is the most clinically significant interaction. Gan Cao (licorice) at the high dose in this formula can cause potassium depletion through a pseudoaldosteronism mechanism. Low potassium levels allow digoxin to bind more strongly to heart cells, significantly increasing the risk of digoxin toxicity, which can cause dangerous heart rhythm disturbances. This combination should be avoided or used only with close electrolyte monitoring.

Potassium-depleting diuretics

Loop diuretics (furosemide) and thiazide diuretics already reduce potassium levels. The additive potassium-lowering effect of Gan Cao can lead to dangerously low potassium (hypokalemia), causing muscle weakness, fatigue, and potentially serious cardiac arrhythmias.

Antihypertensive medications

Gan Cao promotes sodium and water retention, which can raise blood pressure and directly counteract the effects of antihypertensive drugs including ACE inhibitors (captopril, enalapril), ARBs (losartan, valsartan), and calcium channel blockers.

Warfarin and anticoagulants

Licorice may accelerate the metabolism of warfarin, reducing its anticoagulant effect and increasing the risk of blood clot formation. Patients on warfarin should have their INR monitored more frequently if taking this formula.

Corticosteroids

Both Gan Cao and corticosteroids (prednisone, dexamethasone) promote sodium retention and potassium loss. Combined use may amplify side effects including edema, hypertension, and hypokalemia.

Contraindications

Avoid

Palpitations or irregular pulse caused by excess patterns such as Phlegm obstruction, Blood stasis, or Water Qi attacking the Heart. This formula is designed for deficiency conditions and should not be used when the root cause is an excess pathogen blocking the Heart vessels.

Avoid

Spleen and Stomach Dampness with fullness, nausea, or vomiting. The rich, cloying nature of the Yin-nourishing herbs (Sheng Di Huang, E Jiao, Mai Men Dong, Ma Ren) can worsen Dampness and impair digestion.

Caution

Severe Yin deficiency with pronounced Heat signs (e.g. late-stage warm-febrile disease with high fever). The warming herbs Gui Zhi, Sheng Jiang, and the rice wine can further damage Yin fluids. In such cases, the Wen Bing school's Jia Jian Fu Mai Tang (which removes the warming herbs) is more appropriate.

Caution

Hypertension or edema. Gan Cao (licorice) in the large dose used in this formula can promote sodium and water retention and potassium excretion (pseudoaldosteronism), potentially worsening high blood pressure or fluid retention.

Caution

Patients taking digoxin, potassium-depleting diuretics, warfarin, or corticosteroids. The high-dose Gan Cao (licorice) in this formula has well-documented pharmacological interactions with these drugs.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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