Formula

Tong Qiao Huo Xue Tang

通竅活血湯

Also known as:

Tong Qiao Huo Xue Tang , Persica and Musk Combination , Open the Portals and Quicken the Blood Decoction

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula designed to improve blood circulation in the head and face, used for stubborn headaches, hair loss, hearing difficulties, skin discolorations, and other problems caused by stagnant blood obstructing the sensory organs. It works by powerfully moving blood and opening the body's orifices (eyes, ears, nose, mouth) in the upper body.

Formula Category

Main Actions

  • Invigorates Blood and dispels stasis
  • Opens the orifices
  • Frees the flow of the network vessels
  • Promotes Blood circulation in the head and face

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Tong Qiao Huo Xue Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Tong Qiao Huo Xue Tang addresses this pattern

This is the formula's primary and defining pattern. Wang Qing Ren theorized that when stagnant blood accumulates in the fine vessels of the head and face, it blocks the sensory orifices and starves the skin, hair, and sense organs of nourishment. The formula's entire design targets this mechanism: She Xiang opens the orifices, Tao Ren and Hong Hua break up the stasis, Chuan Xiong directs the action upward to the head, and Cong Bai with Huang Jiu carry everything to the upper body. The result is restored blood flow through the head's network vessels, resolving the obstructions that cause headache, hair loss, deafness, and facial discolorations.

A practitioner would look for one or more of these signs

Headaches

Chronic or fixed headache, often stabbing in character, worsened over time

Hair Loss

Hair loss or alopecia, particularly following illness or emotional stress

Hearing Loss

Chronic or long-standing deafness or hearing decline

Rosacea

Redness of the nose (rosacea) due to blood stasis

Vitiligo

White or purple patches on the skin (vitiligo or purpura)

Dark Facial Complexion

Purple or dark discoloration of the face

Red Eyes

Eye pain with red sclera

How It Addresses the Root Cause

This formula addresses a pattern where Blood stasis has lodged in the head, face, and sensory orifices, obstructing the fine vessels (络脉, luò mài) that nourish these structures. In TCM understanding, the head is the "meeting place of all Yang" and depends on a rich, unimpeded supply of Blood to nourish the sense organs, scalp, skin, gums, and brain. When Blood becomes stagnant in these superficial and upper-body vessels, the orifices (eyes, ears, nose, mouth) lose their nourishment and become blocked.

Wang Qingren, the formula's creator, observed that many chronic conditions of the head and face — long-standing deafness, hair loss after febrile illness, rosacea, vitiligo, purpura, gum disease — shared a common root: old, stagnant Blood occupying the small vessels, preventing fresh Blood from reaching the tissues. He wrote that after infectious diseases such as febrile illness, the blood vessels sustain damage and Blood congeals within them. When new Blood cannot flow through to nourish the hair roots, hair falls out. When stagnant Blood blocks the tiny passages near the ear, hearing fails. When it pools under the facial skin, discoloration or rosacea results.

The pathomechanism can also extend to internal organ depletion. In women's "dry blood taxation" (干血劳), prolonged Blood stasis internally prevents the generation of new Blood, leading to amenorrhea, cough, wasting, and afternoon fevers. In children's nutritional impairment (疳证), stagnant Blood causes the visible blue-green veins on a distended abdomen, emaciation, and tidal fever. In both cases, the underlying logic is the same: stasis blocks renewal, and the body starves for fresh Blood.

Formula Properties

Temperature

Warm

Taste Profile

Predominantly acrid (pungent) and warm, with aromatic penetrating qualities from She Xiang and Cong Bai — acrid to move Blood and open the orifices, warm to promote circulation, with sweet notes from Da Zao to harmonize.

Target Organs
Heart Liver Brain
Channels Entered
Heart Liver Pericardium

Formula Origin

Yi Lin Gai Cuo (医林改错, Correction of Errors in Medical Classics) by Wang Qing Ren (王清任)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Tong Qiao Huo Xue Tang

Detailed information about each herb in Tong Qiao Huo Xue Tang and their roles

She Xiang
She Xiang

Musk

Dosage: 0.1 - 0.15g

Temperature Warm
Taste Pungent
Organ Affinity Spleen, Heart, Liver
Parts Used Musk gland of the deer
Role in Tong Qiao Huo Xue Tang

The pivotal herb of the entire formula. She Xiang has an intensely aromatic, penetrating nature that powerfully opens orifices and unblocks the network vessels of the head and face. Wang Qing Ren considered it absolutely indispensable, writing that the formula's success 'depends entirely on good musk.' It drives the blood-moving herbs into the fine vessels and sensory orifices where stagnant blood is lodged.

Tao Ren
Tao Ren

Peach kernels

Dosage: 9g

Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Heart, Large Intestine, Liver
Parts Used Dried ripe seed
Role in Tong Qiao Huo Xue Tang

A major blood-moving herb that breaks up stasis and unblocks the blood vessels. Used at a relatively high dose, it works alongside Hong Hua to form the core blood-activating pair, directly addressing the accumulated stagnant blood in the head and face that causes the formula's target symptoms.

Hong Hua
Hong Hua

Safflowers

Dosage: 9g

Temperature Warm
Taste Pungent
Organ Affinity Heart, Liver
Parts Used Dried flower
Role in Tong Qiao Huo Xue Tang

Powerfully activates blood and dispels stasis, working in tandem with Tao Ren. Hong Hua is particularly effective at reaching the fine network vessels and promoting the flow of blood through constricted channels, helping to resolve the stasis that obstructs the head and facial orifices.

Chi Shao
Chi Shao

Red peony roots

Dosage: 3 - 6g

Temperature Cool
Taste Bitter
Organ Affinity Liver
Parts Used Dried root
Role in Tong Qiao Huo Xue Tang

Clears heat from the blood level and activates blood circulation. Its cooling nature balances the warm, acrid character of the other herbs and helps to cool any heat generated by prolonged blood stasis, while supporting the overall blood-moving action.

Chuan Xiong
Chuan Xiong

Szechuan lovage roots

Dosage: 3 - 6g

Temperature Warm
Taste Pungent
Organ Affinity Gallbladder, Liver, Pericardium
Parts Used Dried rhizome
Role in Tong Qiao Huo Xue Tang

A key blood-activating herb with a strong ascending, upward-moving nature that guides the other medicinals toward the head. Known as the 'commander of blood within Qi,' Chuan Xiong is especially effective at treating headaches and promoting circulation in the upper body.

Sheng Jiang
Sheng Jiang

Fresh ginger

Dosage: 9g

Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach
Parts Used Fresh root
Role in Tong Qiao Huo Xue Tang

Warms the channels and assists the dispersing, yang-opening action of Cong Bai. Fresh ginger promotes the movement of Qi and blood, helps the formula reach the exterior, and harmonizes the Stomach to prevent any discomfort from the blood-moving herbs.

Da Zao
Da Zao

Jujube dates

Dosage: 7 pieces

Temperature Warm
Taste Sweet
Organ Affinity Spleen, Stomach
Parts Used Dried ripe fruit
Role in Tong Qiao Huo Xue Tang

Tonifies Qi, nourishes the blood, and harmonizes the formula. Its sweet, gentle nature moderates the strong blood-moving and aromatic herbs, protecting the Stomach and ensuring that the vigorous stasis-dispelling action does not damage the body's normal Qi and blood.

Cong Bai
Cong Bai

Scallions

Dosage: 3 stalks

Temperature Warm
Taste Pungent
Organ Affinity Lungs, Stomach
Parts Used Bulb
Role in Tong Qiao Huo Xue Tang

Its acrid, warm, dispersing nature opens yang Qi and guides the formula's action upward to the head and outward to the body surface. Together with Sheng Jiang, it frees the flow of yang through the channels and helps the blood-moving herbs reach the superficial network vessels of the head and face.

Modern Research (4 studies)

  • Systematic Review and Meta-Analysis: Tongqiao Huoxue Decoction for Acute Ischemic Stroke (2022)
  • Systematic Review: Tongqiao Huoxue Decoction Combined with Western Medicine for Ischemic Stroke (2020)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

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Best Time to Take

Before bed (临卧服, lín wò fú) — this is explicitly specified in the original text. Evening administration aligns with the body's natural inward movement of Blood at night.

Typical Duration

Short course: traditionally 3–6 doses taken over consecutive evenings, with reassessment. Chronic conditions may require 2–4 weeks of intermittent use with practitioner supervision.

Dietary Advice

Avoid cold and raw foods (ice, raw salads, chilled drinks) during treatment, as cold constricts blood vessels and counteracts the formula's warming, Blood-moving action. Avoid greasy, heavy, and overly rich foods that may generate Dampness and obstruct circulation. Reduce alcohol intake beyond what is used in the formula's preparation. Foods that gently support Blood circulation are favorable, such as small amounts of vinegar, hawthorn, turmeric in cooking, and dark leafy greens. Adequate warm water intake is recommended to support the movement of Blood.

Special Populations

Pregnancy

Contraindicated in pregnancy. She Xiang (Moschus/Musk) is classified as a powerful orifice-opening substance with known uterine-stimulating properties that can induce miscarriage. Modern pharmacological research confirms that muscone, the primary active compound in She Xiang, excites the uterus. Additionally, Tao Ren (Peach Kernel) and Hong Hua (Safflower) are strong Blood-moving herbs that can promote uterine contractions and increase the risk of hemorrhage. Even in modern formulations where She Xiang is replaced by substitutes like Shi Chang Pu or Bai Zhi, the formula's overall Blood-invigorating action remains too strong for use during pregnancy. This formula should be strictly avoided throughout all trimesters.

Breastfeeding

Use with caution during breastfeeding. She Xiang (Moschus/Musk) and its active compound muscone are aromatic and highly penetrating substances that may transfer into breast milk. The strong Blood-moving herbs (Tao Ren, Hong Hua) could also theoretically affect the nursing infant. If the original formula with She Xiang is used, breastfeeding should be suspended during treatment. Modified versions without She Xiang carry lower risk but should still be used only under practitioner supervision. Huang Jiu (yellow wine) used in the traditional preparation may contribute trace alcohol to breast milk, which is another consideration for nursing mothers.

Pediatric Use

Wang Qingren specifically included pediatric dosing guidance in his original text. For children aged 7-8 years, one adult dose should be divided and taken over two evenings. For children aged 2-3 years, one adult dose should be divided over three evenings. The She Xiang (musk) portion can be reused (re-decocted) up to three times before replacing with fresh musk. The formula was originally indicated for childhood nutritional impairment (疳证, gān zhèng), characterized by a distended abdomen with visible blue-green veins, emaciation, dry and brittle hair, and afternoon tidal fevers. In such cases, Wang recommended rotating this formula with Xue Fu Zhu Yu Tang and Ge Xia Zhu Yu Tang. Modern pediatric use should be supervised by a qualified practitioner, and the She Xiang component requires particular caution in young children due to its strong aromatic penetrating nature.

Drug Interactions

Anticoagulant and antiplatelet medications: Tao Ren (Peach Kernel), Hong Hua (Safflower), Chi Shao (Red Peony Root), and Chuan Xiong (Szechuan Lovage) all have demonstrated antiplatelet and blood-flow-promoting properties. Combined use with warfarin, heparin, aspirin, clopidogrel, or direct oral anticoagulants (DOACs) may increase the risk of bleeding. Close monitoring of INR and bleeding signs is advised.

Thrombolytic agents: If used in the context of ischemic stroke, the formula should not be administered concurrently with thrombolytic drugs (e.g. tPA) due to the additive risk of hemorrhage.

Sedative and CNS-active drugs: She Xiang (Moschus) has CNS-stimulating properties (muscone excites the central nervous system). This may interact with sedatives, anxiolytics, or antiepileptic drugs, potentially altering their effectiveness.

Alcohol-containing preparation: The traditional preparation uses Huang Jiu (yellow wine, approximately 250 mL). This may interact with any medication that has a known alcohol interaction, including metronidazole, certain cephalosporins, and disulfiram.

Contraindications

Avoid

Pregnancy. She Xiang (Moschus) is a powerful orifice-opening substance that strongly stimulates the uterus and can cause miscarriage. Tao Ren and Hong Hua are also potent Blood-moving herbs contraindicated in pregnancy.

Avoid

Active hemorrhage or hemorrhagic disorders (e.g. hemorrhagic stroke in the acute bleeding phase, active gastrointestinal bleeding, coagulation disorders). The formula's strong Blood-moving action could worsen bleeding.

Caution

Heavy menstrual bleeding or menorrhagia. The Blood-invigorating herbs may significantly increase menstrual flow.

Caution

Patients with Blood deficiency without significant Blood stasis. This formula strongly disperses and moves Blood; if the underlying condition is primarily deficiency, it may further deplete Blood and Qi.

Caution

Patients on anticoagulant or antiplatelet therapy (e.g. warfarin, heparin, aspirin, clopidogrel). The formula's Blood-moving action may potentiate anticoagulant effects and increase bleeding risk.

Cautions & Warnings

is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Liu Wei Di Huang Wan.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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