Formula

Sheng Ma Ge Gen Tang

Cimicifuga and Kudzu Decoction | 升麻葛根汤

Also known as:

Shēng Má Gé Gēn Tāng

Properties

Exterior-releasing formulas · Cool

Key Ingredients

Sheng Ma, Ge Gen

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula designed to help the body push out rashes that are struggling to surface, while easing fever, headache, and body aches. Originally developed for measles in children during the early stage when the rash has not yet fully emerged, it is now more broadly used for feverish conditions with skin eruptions, sore throat, and viral infections.

Formula Category

Main Actions

  • Releases the muscle layer
  • Vents rashes and promotes eruption
  • Clears Heat and resolves toxins
  • Disperses Wind-Heat from the exterior

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Sheng Ma Ge Gen Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Sheng Ma Ge Gen Tang addresses this pattern

When external Wind-Heat attacks the Lung and Yangming systems, it produces fever, headache, cough, red eyes, and thirst. In children, this pattern frequently manifests with skin eruptions that struggle to emerge fully. Sheng Ma and Ge Gen release the exterior at the Yangming level and vent pathogenic factors outward through the skin. Shao Yao cools the Blood layer to prevent deeper penetration of Heat, while Zhi Gan Cao supports the middle Qi needed to drive the outward movement. The formula is specifically designed for this pattern when rashes are present or imminent.

A practitioner would look for one or more of these signs

Fever

Mild to moderate fever with body aches

Headaches

Headache from exterior Wind-Heat

Hypochondrial Pain That Is Worse On Coughing And Breathing

Cough with possible sneezing

Red Eyes

Red, watery eyes

Thirst

Thirst from Heat consuming fluids

Skin Rashes

Rash that has appeared but not fully surfaced

How It Addresses the Root Cause

This formula addresses an exterior pattern where Wind-Heat (or seasonal epidemic toxins) invades the body surface and becomes trapped in the muscle layer, particularly affecting the Lung and Stomach systems via the Yangming channel. When these pathogenic factors lodge in the exterior, the body's normal ability to vent outward through the skin is obstructed. This creates a situation where an eruptive rash (such as measles) that should emerge and resolve naturally instead stalls and fails to fully surface.

The key problem is a blockage at the interface between the interior and the exterior. Heat and toxins are building up inside, but the body's defensive Qi cannot push them out through the skin. This produces fever, headache, body aches, and restlessness. The eyes may become red and teary, the mouth dry, and the tongue red with a thin coating, all reflecting Heat constrained at the Qi level. If the rash remains suppressed, the trapped toxins can drive deeper and cause more serious complications. The therapeutic logic is therefore to open the muscle layer, vent the pathogen outward through the skin, and allow the rash to fully emerge so the body can expel the Heat-toxin naturally.

Formula Properties

Temperature

Cool

Taste Profile

Predominantly acrid (pungent) and sweet with a mildly bitter undertone — acrid to disperse and vent the exterior, sweet to moderate and harmonize, bitter to gently clear Heat.

Target Organs
Lungs Stomach Spleen Large Intestine
Channels Entered
Lung Large Intestine Stomach Spleen

Formula Origin

Yán Shì Xiǎo Ér Fāng Lùn (阎氏小儿方论), appended to Xiǎo Ér Yào Zhèng Zhí Jué (小儿药证直诀) by Qián Yǐ (钱乙), compiled by Yán Xiàozhōng (阎孝忠)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Sheng Ma Ge Gen Tang

Detailed information about each herb in Sheng Ma Ge Gen Tang and their roles

Kings
Deputies
Envoys
Sheng Ma
Sheng Ma

Bugbane rhizomes

Dosage: 6 - 10g

Temperature Cool
Taste Pungent, Sweet
Organ Affinity Large Intestine, Lungs, Spleen, Stomach
Parts Used Dried rhizome
Role in Sheng Ma Ge Gen Tang

Releases the muscle layer of the Yangming channel, vents rashes outward, clears Heat, and resolves toxins. As a key herb for both exterior release and rash eruption, it directly addresses the core pathomechanism of toxin trapped beneath the skin.

Ge Gen
Ge Gen

Kudzu roots

Dosage: 6 - 10g

Temperature Cool
Taste Pungent, Sweet
Organ Affinity Spleen, Stomach
Parts Used Dried root
Role in Sheng Ma Ge Gen Tang

Releases the muscle layer, promotes the eruption of rashes, generates fluids to protect against dehydration from fever, and raises clear Yang of the Spleen and Stomach. Pairs with Sheng Ma as a classical combination for exterior release and rash venting.

Chi Shao
Chi Shao

Red peony roots

Dosage: 4 - 6g

Temperature Cool
Taste Bitter
Organ Affinity Liver
Parts Used Dried root
Role in Sheng Ma Ge Gen Tang

Harmonizes the nutritive (Ying) level and clears Heat from the Blood. By cooling the Blood layer, it supports the outward venting of rashes while preventing the pathogenic Heat from sinking deeper into the body.

Gan Cao
Gan Cao

Liquorice

Dosage: 2 - 3g

Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Dried root and rhizome
Role in Sheng Ma Ge Gen Tang

Harmonizes the actions of all the other herbs, supports the middle Qi to provide a foundation for the outward-pushing strategy, and contributes mild toxin-resolving action.

Modern Research (3 studies)

  • In Vitro Study: Anti-measles virus activity of Shengma-Gegen-Tang in Vero cells and human PBMCs (1997)
  • In Vitro Study: Sheng-Ma-Ge-Gen-Tang inhibited Enterovirus 71 infection in human foreskin fibroblast cell line (2008)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Between meals, taken warm, 2–3 times daily. The classical text states 'regardless of time' (不拘时服), meaning it can be taken as needed during acute illness.

Typical Duration

Acute use: typically 3–5 days, discontinued once the rash has fully erupted or symptoms resolve.

Dietary Advice

While taking this formula, favor light, easily digestible foods such as rice porridge, steamed vegetables, and clear soups. Avoid greasy, fried, or heavy foods that can obstruct the Stomach and impair the formula's outward-venting action. Cold and raw foods (including salads, ice cream, and chilled drinks) should be minimized as they can constrain the exterior and prevent proper rash eruption. Spicy and strongly warming foods (such as lamb, chili, and alcohol) should also be avoided, as they can aggravate interior Heat. Adequate warm fluid intake is important to support the body's effort to expel the pathogen through the skin.

Special Populations

Pregnancy

Generally considered safe at standard dosages for short-term use, but should only be used during pregnancy under professional guidance. Sheng Ma (Cimicifuga) has a lifting and dispersing nature that some classical sources caution against in pregnancy due to its potential to mobilize Qi upward and outward, which theoretically could disturb the fetus. Bai Shao (White Peony) in standard doses is not a concern. Gan Cao (Licorice) in large or prolonged doses may contribute to fluid retention. Overall risk is low for short courses treating acute febrile illness, but a qualified practitioner should assess the individual situation.

Breastfeeding

Generally considered compatible with breastfeeding at standard dosages for short-term acute use. The herbs in this formula are mild and have no well-documented concerns regarding transfer through breast milk or adverse effects on the nursing infant. Gan Cao (Licorice) in prolonged or high doses could theoretically promote fluid retention in the mother. If the breastfeeding mother has an acute febrile illness with rash, the formula may be used under professional supervision. Discontinue if the infant shows any unusual symptoms such as digestive upset or irritability.

Pediatric Use

This formula was originally designed specifically for pediatric use by the Song Dynasty children's medicine specialist Qian Yi. It remains one of the most commonly used formulas for childhood eruptive febrile diseases such as measles. For children, dosages are typically reduced to one-third to one-half of the adult dose depending on age and body weight. Infants under one year should only receive the formula under close professional supervision with further dose reduction. The formula is considered gentle and well-suited to children's delicate constitutions, but should not be continued once the rash has fully emerged. As with all pediatric herbal prescriptions, monitor for any signs of digestive upset and ensure adequate fluid intake.

Drug Interactions

Gan Cao (Glycyrrhiza / Licorice): This herb contains glycyrrhizin, which can interact with several classes of pharmaceuticals. It may reduce the effectiveness of antihypertensive medications by promoting sodium retention and potassium excretion. It can potentiate the effects of corticosteroids and increase the risk of hypokalemia when combined with diuretics (especially thiazides and loop diuretics). In patients taking digoxin or other cardiac glycosides, licorice-induced hypokalemia may increase the risk of toxicity.

Ge Gen (Pueraria / Kudzu Root): Contains isoflavones (notably puerarin) that have documented cardiovascular effects including lowering blood pressure and blood sugar. Patients on antidiabetic medications or antihypertensive drugs should be monitored for additive effects. Puerarin may also affect the metabolism of certain drugs through cytochrome P450 pathways.

Bai Shao (White Peony Root): The classical contraindication states that Bai Shao opposes Li Lu (Veratrum). While this is a traditional herb-herb incompatibility rather than a drug interaction, it should be noted. Peony's mild blood-cooling properties are unlikely to produce significant pharmaceutical interactions at standard doses.

Given the formula's short-term acute use profile, clinically significant interactions are uncommon at standard dosages, but patients on cardiovascular medications, corticosteroids, or blood-sugar-lowering drugs should inform their healthcare provider.

Contraindications

Avoid

Rashes that have already fully erupted. Once the measles or other skin eruption has completely emerged, the dispersing and venting action of this formula is no longer appropriate and may scatter Qi unnecessarily.

Avoid

Qi or Yin deficiency with no exterior pathogen. The outward-dispersing nature of this formula can further deplete a patient who is already weak, especially if the rash failure is due to insufficient Qi rather than a pathogenic blockage.

Avoid

Rashes caused by Blood deficiency or Cold patterns. This formula is designed for Wind-Heat constraining the exterior. If the rash fails to emerge because of interior Cold or Blood deficiency, warming or tonifying formulas are needed instead.

Caution

Excessive sweating or a depleted exterior. In patients who are already perspiring freely, additional exterior-releasing herbs may damage Yin and fluids.

Caution

Pre-existing Spleen and Stomach weakness with poor appetite and loose stools. The cool, dispersing properties of the formula may further impair digestion. Use with caution and consider adding Spleen-supportive herbs.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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