Divide the daily decoction into 3 doses, taken warm between meals (mid-morning, mid-afternoon, and before bed). The evening dose is especially important for sleep and Essence-related complaints.

Typically prescribed for 2-4 weeks initially, then reassessed. Chronic conditions such as insomnia, anxiety, or recurrent seminal emission may require 4-8 weeks or longer with periodic review.

Classical texts specify avoiding raw scallions (生葱), cold water, seaweed (海藻), Chinese cabbage (菘菜), and pork while taking this formula. More generally, avoid cold and raw foods, iced drinks, and greasy or difficult to digest foods, as these can impair the Spleen's ability to transform and transport, undermining the formula's goal of restoring balance. Alcohol should be minimized as it generates Heat and disturbs the spirit. Favor warm, easy to digest, nourishing foods such as congee, cooked grains, root vegetables, warm soups, and moderate amounts of protein. Foods that gently support the Kidneys (walnuts, black sesame, small amounts of lamb) and calm the spirit (lotus seeds, lily bulb, longan fruit) complement the formula's actions.

Guizhi Jia Longgu Muli Tang has the effects of harmonizing Yin and Yang, calming, and securing Essence. It is primarily used to treat Deficiency-related conditions such as tension and tightness in the lower abdomen, cold sensation in the genital area, dizziness, hair loss, nocturnal emissions in men, and dreams of sexual intercourse in women. Other symptoms may include palpitations, involuntary urination, and a weak, large, hollow, slow, or slightly tight pulse.

In modern practice, this formula is used for conditions like hysteria, insomnia, nocturnal emissions or spermatorrhea, infertility, threatened miscarriage, chronic diarrhea, menopausal syndrome, night sweats, pediatric bronchitis, chronic urticaria, and cervical spondylosis, particularly when they align with the patterns described above.

Gan Cao (Licorice Root): Glycyrrhizin in Gan Cao can cause potassium depletion and sodium/water retention with prolonged use. It may interact with diuretics (increasing the risk of hypokalemia), cardiac glycosides such as digoxin (hypokalemia increases sensitivity to digoxin toxicity), corticosteroids (additive mineralocorticoid effects), and antihypertensive medications (opposing their blood pressure lowering effect through fluid retention).

Long Gu and Mu Li (Dragon Bone and Oyster Shell): These mineral substances are rich in calcium carbonate and calcium phosphate. The calcium content may reduce the absorption of tetracycline antibiotics, fluoroquinolone antibiotics, bisphosphonates, levothyroxine, and iron supplements if taken simultaneously. It is advisable to separate administration by at least two hours. Patients already taking calcium supplements or with conditions requiring calcium monitoring (such as hyperparathyroidism) should exercise caution.

Gui Zhi (Cinnamon Twig): Contains cinnamaldehyde and related compounds. Theoretical interactions exist with anticoagulant/antiplatelet drugs (cinnamon may have mild blood-thinning properties), though the clinical significance at standard herbal doses is uncertain. Patients on warfarin or similar medications should be monitored.