Formula

Dao Chi San

Guide out the red formula | 导赤散

Also known as:

Dao Chi Tang , Eliminating Redness Powder , Guide Out the Red Powder

Properties

Heat-clearing formulas · Cold

Key Ingredients

Shu Di huang, Mu Tong

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A gentle classical formula that clears heat from the Heart and promotes urination to relieve symptoms like mouth sores, irritability, a flushed face, and painful or dark-colored urination. Originally designed for children by the famous Song dynasty pediatrician Qian Yi, it is also widely used in adults for similar heat-related complaints.

Formula Category

Main Actions

  • Clears Heart Fire
  • Nourishes Yin
  • Promotes urination and relieves painful urinary dysfunction
  • Guides Heat downward via the Small Intestine
  • Cools the Blood

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dao Chi San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Dao Chi San addresses this pattern

Heart Fire flaring upward causes irritability, a flushed face, mouth and tongue sores, thirst with craving for cold drinks, and a red tongue tip. Dao Chi San addresses this by using Sheng Di Huang to cool Heart Blood and nourish Yin, Dan Zhu Ye to clear Heart Heat and calm the mind, and Mu Tong to drain the Fire downward through urination. The classical name "Guide Out the Red" refers to guiding Heart Fire (red belongs to the Heart in five-phase theory) out through the urine. Because the formula nourishes Yin while clearing Heat, it is particularly suited to Heart Fire that arises partly from insufficient Yin fluids rather than pure excess, which is why the Yi Zong Jin Jian commentary describes the target condition as "water deficient, fire not fully excess."

A practitioner would look for one or more of these signs

Mouth Ulcers

Especially on the tongue tip, a key indicator of Heart Fire

Irritability

Restlessness and feeling of heat in the chest

Thirst

With craving for cold drinks

Facial Flushing

Red face due to Heat flaring upward

Insomnia

Difficulty sleeping due to Heart Heat disturbing the Spirit

How It Addresses the Root Cause

Dao Chi San addresses a condition where Heat accumulates in the Heart system and potentially transfers downward to its paired organ, the Small Intestine. In TCM, the Heart governs the mind and opens to the tongue, while the Heart and Small Intestine share an interior-exterior relationship through their connecting channels. When Heat lodges in the Heart, it flares upward along the channel, producing irritability, a sensation of heat in the chest, facial redness, thirst with a craving for cold drinks, and sores on the tongue or mouth.

A critical nuance of this pattern is that it is not simple excess Fire. The classical commentary in the Yi Zong Jin Jian characterizes it as "Water deficient, Fire not truly excess" (水虚火不实). This means the Heat arises partly because Kidney Yin (the body's cooling, moistening Water) is insufficient to keep Heart Fire in check. The Heart-Kidney axis, which normally maintains balance through the upward rising of Kidney Water and the downward descent of Heart Fire, has become disrupted. With Water below failing to control Fire above, Heat accumulates in the Heart. If this Heat then transfers downward into the Small Intestine (which governs the separation of clear and turbid fluids), it disrupts urinary function, producing dark, scanty, painful urination.

The formula's strategy directly follows from this mechanism: rather than attacking the Heat head-on with harsh bitter-cold herbs (which would damage the Stomach and further deplete fluids), it gently clears Heart Heat while simultaneously nourishing the Yin below, and opens a downward pathway through the urinary system to draw the Heat out of the body via the urine. This two-pronged approach of "cooling above while nourishing below" reflects the formula's elegant design for a condition that is not purely excess nor purely deficient.

Formula Properties

Temperature

Cold

Taste Profile

Predominantly sweet and bitter with a bland quality — sweet (Sheng Di Huang, Gan Cao) to nourish Yin and moderate the formula, bitter (Mu Tong) to drain Heat downward, and bland (Zhu Ye) to promote gentle diuresis.

Target Organs
Heart Small Intestine Kidneys Urinary Bladder
Channels Entered
Heart Small Intestine Kidney Bladder

Formula Origin

Xiao Er Yao Zheng Zhi Jue (小儿药证直诀, Key to Therapeutics of Children's Diseases) by Qian Yi (钱乙)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Dao Chi San

Detailed information about each herb in Dao Chi San and their roles

Kings
Deputies
Envoys
Shu Di huang
Shu Di huang

Prepared rehmannia

Dosage: 9 - 15g

Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver
Parts Used Prepared dried root tuber
Role in Dao Chi San

Clears Heat and cools the Blood while nourishing Yin. By replenishing Kidney Yin (the body's deep cooling reserves), it helps restrain Heart Fire from above. Its sweet, cold nature addresses both the heat and the underlying fluid depletion that makes the heat harder to resolve.

Mu Tong
Mu Tong

Akebia stems

Dosage: 3 - 6g

Temperature Cold
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine
Parts Used Dried stem
Role in Dao Chi San

Enters the Heart and Small Intestine channels. In the upper body, it clears Heart Fire; in the lower body, it promotes urination and drains Heat from the Small Intestine. Paired with Sheng Di Huang, it creates a balanced approach: clearing Heat downward through the urine while Sheng Di Huang replenishes Yin, so that promoting urination does not further deplete fluids.

Dan Zhu Ye
Dan Zhu Ye

Lophatherum herbs

Dosage: 6 - 12g

Temperature Cold
Taste Sweet
Organ Affinity Heart, Small Intestine, Stomach
Parts Used Dried stem and leaf
Role in Dao Chi San

Clears Heart Heat and relieves restlessness with its sweet, bland, and cold nature. Its mild diuretic action helps guide Heat downward and out through the urine, reinforcing the formula's strategy of directing Heart Fire away from the upper body.

Gan Cao
Gan Cao

Liquorice

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Dried root and rhizome
Role in Dao Chi San

The tip of raw licorice root (Gan Cao Shao) is specifically chosen because classical teaching holds that it reaches the lower urinary tract to relieve painful urination. It also clears Heat, resolves toxins, and harmonizes the other ingredients, while protecting the Stomach from the cold nature of Sheng Di Huang and Mu Tong.

Modern Research (1 study)

  • Dao-Chi Powder Ameliorates Pancreatitis-Induced Intestinal and Cardiac Injuries via Regulating the Nrf2-HO-1-HMGB1 Signaling Pathway in Rats (Preclinical animal study, 2022)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

After meals (食后温服), taken warm, typically twice daily. The original text specifies taking it warm after eating to protect the Stomach from the formula's cold nature.

Typical Duration

Acute use: 3–7 days, reassessed by practitioner. Not intended for long-term use.

Dietary Advice

While taking this formula, avoid foods that generate internal Heat or are overly warming: spicy foods (chili, pepper, ginger, garlic in large amounts), fried and greasy foods, lamb, alcohol, and strong coffee. These can aggravate the Heart Fire the formula is working to clear. Favor cooling, bland, and lightly moistening foods: mung bean soup, watermelon, cucumber, pear, lotus seed, winter melon, barley water (yi mi shui), and leafy greens. These support the formula's action of clearing Heat and nourishing fluids. Avoid excessively cold or raw foods if digestion is weak, as the formula itself is already cold in nature and adding more cold food may upset the Stomach. Room-temperature or lightly cooked meals are preferable for those with sensitive digestion.

Special Populations

Pregnancy

Use with caution during pregnancy. Mu Tong (Akebia or Clematis stem) has a downward-draining, cold nature that is generally considered inadvisable during pregnancy. Historically, Mu Tong has been listed among herbs to avoid in pregnancy due to its strong downward-moving and urination-promoting properties, which could theoretically affect the stability of pregnancy. Sheng Di Huang (raw Rehmannia) is cold and can be overly cooling for pregnant women with already weakened digestion. If the formula were ever prepared with the banned Guan Mu Tong (Aristolochia) variety, it would be absolutely contraindicated due to aristolochic acid's known toxicity. With safe Mu Tong varieties, the formula should only be used during pregnancy under direct supervision of a qualified practitioner and only when clearly indicated, at reduced dosage, for the shortest duration necessary.

Breastfeeding

Generally considered compatible with breastfeeding when used at standard doses for short durations under professional guidance. The herbs in Dao Chi San are mild in nature. Sheng Di Huang and Gan Cao are commonly used postpartum without reported adverse effects on nursing infants. Mu Tong's cold and draining properties warrant some caution, as strongly cold herbs could theoretically affect the mother's digestive function and milk production. There are no specific reports of toxicity through breast milk with safe (non-aristolochic acid) Mu Tong varieties. However, the formula's overall cold nature may reduce milk supply if used excessively, as lactation in TCM is supported by warm Qi and Blood flow. Use the lowest effective dose for the shortest time needed, and discontinue if any signs of digestive upset appear in the nursing infant.

Pediatric Use

Dao Chi San was originally designed as a pediatric formula by the Song dynasty pediatric specialist Qian Yi, and it remains one of the most commonly used formulas for children in TCM practice. Its gentle composition (avoiding harsh bitter-cold herbs like Huang Lian) makes it well-suited to children's delicate constitutions. Dosage should be adjusted by age and body weight. A common modern guideline is roughly one-third to one-half of the adult dose for children aged 3–6, and two-thirds for children aged 7–12. For infants and toddlers (under 3), use only under direct practitioner supervision at significantly reduced doses. The original text specified 9g of the powdered formula per dose for children, decocted with bamboo leaves. The formula is appropriate for pediatric conditions such as mouth sores (stomatitis, thrush), night crying attributed to Heart Heat, restless sleep with teeth grinding, and urinary discomfort with dark urine. It should be used for the acute presentation only and discontinued once symptoms resolve. Monitor the child's digestion and stool; if loose stools develop, the formula should be reduced or stopped.

Drug Interactions

Diuretic medications: Mu Tong (Akebia/Clematis stem) and Zhu Ye (bamboo leaf) both promote urination. Concurrent use with pharmaceutical diuretics (furosemide, hydrochlorothiazide, spironolactone) could potentiate fluid loss and increase the risk of dehydration or electrolyte imbalances, particularly hypokalemia.

Lithium: Because the formula promotes urination, it may alter lithium clearance. Changes in sodium and fluid balance can affect lithium blood levels, potentially leading to toxicity or reduced efficacy.

Gan Cao (Glycyrrhiza/Licorice): Although used in small amounts as Gan Cao Shao (the root tip), glycyrrhizin in licorice can cause pseudoaldosteronism with prolonged use, leading to sodium retention, potassium loss, and elevated blood pressure. This may interact with antihypertensives, corticosteroids, cardiac glycosides (digoxin), and potassium-depleting drugs. The risk is low at the standard small dose used in this formula but increases with prolonged administration.

Anticoagulant and antiplatelet drugs: Sheng Di Huang (raw Rehmannia) has blood-cooling properties and may have mild effects on blood viscosity. Caution is warranted with concurrent warfarin, heparin, or antiplatelet agents, though clinically significant interactions at standard doses have not been well documented.

Contraindications

Caution

Spleen and Stomach deficiency with cold (脾胃虚寒): The formula contains predominantly cold and cool herbs (Sheng Di Huang, Mu Tong, Zhu Ye) that can further damage a weak digestive system, causing loose stools, poor appetite, or abdominal pain.

Caution

True Kidney Yang deficiency with copious clear urination: This formula promotes urination and clears Heat. Using it when there is no Heat and the Kidneys are already failing to warm and consolidate fluids would worsen the condition.

Avoid

Formulas containing Guan Mu Tong (关木通, Aristolochia manshuriensis): If the Mu Tong used is the nephrotoxic Guan Mu Tong variety containing aristolochic acid, the formula must not be used. Only non-toxic varieties of Mu Tong (such as Akebia quinata or Clematis armandii/川木通) should be used. Guan Mu Tong has been banned in China since 2003.

Caution

Pre-existing kidney disease or renal impairment: Even with safe Mu Tong varieties, caution is required due to the diuretic and cold nature of the formula. Dosage and duration should be carefully monitored.

Caution

Heart Fire with true excess (心经实热): The Yi Zong Jin Jian notes this formula is suited for conditions where 'Water is deficient and Fire is not truly excess' (水虚火不实). For true Heart excess Heat, stronger cold-clearing herbs like Huang Lian should be added or a different formula chosen.

Caution

Prolonged or excessive use: This is a formula for acute conditions and should not be taken long-term, as the cold and draining properties may deplete Yin fluids and weaken the Spleen over time.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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