Formula

Chai Hu Gui Zhi Tang

Bupleurum & Cinnamon Twig Decoction | 柴胡桂枝汤

Also known as:

Chai Hu Jia Gui Tang (柴胡加桂汤) , Chai Hu Jia Gui Zhi Tang (柴胡加桂枝汤) , Gui Zhi Chai Hu Ge Ban Tang (桂枝柴胡各半汤)

Properties

Harmonizing formulas · Slightly Warm

Key Ingredients

Chai Hu, Gui Zhi

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula that combines two foundational prescriptions (Xiao Chai Hu Tang and Gui Zhi Tang) at half dosage each. It is used when a lingering illness involves both the body's surface defenses and its deeper regulatory systems, presenting with mild chills and fever, joint aches, slight nausea, and a sense of tightness below the chest. Beyond colds and flu, it is widely applied for digestive pain, joint problems, and conditions where the body seems caught between two stages of illness.

Formula Category

Main Actions

  • Harmonizes the Shaoyang
  • Harmonizes the Nutritive and Defensive Qi
  • Releases the exterior and resolves the half-exterior half-interior
  • Soothes the Liver and regulates Qi
  • Harmonizes the Spleen and Stomach

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Chai Hu Gui Zhi Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Chai Hu Gui Zhi Tang addresses this pattern

This is the primary pattern for which the formula was designed. When a Wind-Cold pathogen has been lingering for several days, it may partially remain at the Tai Yang (body surface) level while also beginning to affect the Shao Yang (half-exterior, half-interior) level. The result is a mixed presentation: the patient still has mild chills and body aches from the unresolved exterior condition, but now also shows signs of Shao Yang involvement such as slight nausea, a sense of tightness or knotting below the chest, and possibly alternating sensations of warmth and cold. The formula addresses both layers simultaneously. Chai Hu and Huang Qin resolve the Shao Yang component by venting pathogenic factors and clearing developing Heat. Gui Zhi and Shao Yao resolve the Tai Yang component by releasing the exterior and harmonizing the Ying and Wei. Ren Shen, Ban Xia, and the remaining herbs support digestion and prevent further inward progression of the illness.

A practitioner would look for one or more of these signs

Fever

Low-grade fever that persists beyond the first few days of illness

Chills

Mild chills, less intense than at the start of the illness

Moving Pain

Aching and restless discomfort in the limbs and joints (支节烦疼)

Nausea

Slight nausea or mild vomiting (微呕)

Chest Stiffness

A sensation of knotting or stuffiness below the chest (心下支结)

Headaches

Headache with stiffness at the back of the neck

How It Addresses the Root Cause

This formula addresses a situation where a person has been ill for about a week and the body's struggle against pathogenic factors has reached a transitional stage. The illness has not fully resolved from the body's surface (the Taiyang level), but has already begun to affect a deeper zone called the Shaoyang, which in TCM represents the space between the exterior and interior of the body.

On the surface level, some exterior cold remains, causing mild chills and aching in the limbs and joints. These are signs that the body's defensive (Wei) and nutritive (Ying) Qi are not yet harmonized. At the same time, pathogenic factors have begun to affect the Shaoyang pivot, the hinge mechanism through which Qi moves between inside and outside. When this pivot is disrupted, Qi stagnates in the chest and rib-side area, producing a sensation of tightness or binding below the heart (心下支结). The Stomach's descending function is mildly impaired, leading to slight nausea. Because both layers are affected simultaneously but neither severely, the classical text deliberately uses the word "mild" (微) twice to emphasize that neither the exterior nor the half-interior symptoms are pronounced.

The core disease logic is one of dual disruption: the exterior defensive system and the interior pivoting mechanism of the Shaoyang are both compromised at the same time. A formula that only releases the exterior would drive the pathogen inward, while one that only harmonizes the Shaoyang would leave the surface unresolved. By combining half-doses of Gui Zhi Tang and Xiao Chai Hu Tang, the formula addresses both layers simultaneously as a gentle, two-level harmonizing strategy.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly bitter and acrid (pungent) with underlying sweetness. The bitter and acrid combination disperses pathogens and moves stagnant Qi, while the sweet herbs (Gan Cao, Da Zao, Ren Shen) harmonize and support the Spleen.

Target Organs
Liver Gallbladder Spleen Stomach Lungs
Channels Entered
Liver Gallbladder Stomach Spleen Bladder

Formula Origin

Shāng Hán Lùn (Treatise on Cold Damage) by Zhāng Zhòngjǐng

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Chai Hu Gui Zhi Tang

Detailed information about each herb in Chai Hu Gui Zhi Tang and their roles

Kings
Deputies
Assistants
Envoys
Chai Hu
Chai Hu

Bupleurum roots

Dosage: 9 - 15g

Temperature Cool
Taste Bitter
Organ Affinity Gallbladder, Liver
Parts Used Dried root and rhizome
Role in Chai Hu Gui Zhi Tang

The primary herb, used at the highest dose. It vents pathogenic factors from the Shao Yang (lesser yang) level outward, unblocks stagnant Qi in the chest and flanks, and serves as the pivot for the formula's harmonizing action between the exterior and interior.

Gui Zhi
Gui Zhi

Cinnamon twigs

Dosage: 4.5 - 9g

Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Lungs, Spleen
Parts Used Dried young branches
Role in Chai Hu Gui Zhi Tang

Warms the channels and releases the remaining exterior Wind-Cold from the Tai Yang (greater yang) level. Together with Shao Yao, it harmonizes the body's protective (Wei) and nutritive (Ying) layers, addressing chills, sweating, and body aches.

Huang Qin
Huang Qin

Baikal skullcap roots

Dosage: 4.5 - 9g

Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen
Parts Used Dried root
Role in Chai Hu Gui Zhi Tang

Clears Heat from the Shao Yang half-interior level. Its bitter, cold, and descending nature complements and balances Chai Hu's acrid, ascending action, preventing the dispersing herbs from damaging Yin or generating excess Heat.

Bai Shao
Bai Shao

White peony roots

Dosage: 4.5 - 9g

Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen
Parts Used Dried root
Role in Chai Hu Gui Zhi Tang

Nourishes Blood and preserves Yin to counterbalance the dispersing action of Gui Zhi. Paired with Gui Zhi, it harmonizes the Ying and Wei. Its sour, astringent nature also helps relax tendons and relieve the joint aches described in the original text.

Ban Xia
Ban Xia

Crow-dipper rhizomes

Dosage: 5 - 9g

Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach
Parts Used Dried rhizome and tuber
Role in Chai Hu Gui Zhi Tang

Directs rebellious Stomach Qi downward, addressing nausea and vomiting. It also transforms Phlegm-Dampness that may accumulate when the Shao Yang pivot is blocked, helping relieve the sensation of fullness and knotting below the chest.

Ren Shen
Ren Shen

Ginseng

Dosage: 4.5 - 9g

Temperature Warm
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Spleen
Parts Used Dried root
Role in Chai Hu Gui Zhi Tang

Tonifies the body's righteous Qi (Zheng Qi) to support recovery and prevent the pathogen from penetrating deeper into the interior. It also restores fluids depleted by the illness and supports Spleen and Stomach function.

Sheng Jiang
Sheng Jiang

Fresh ginger

Dosage: 4.5 - 9g

Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach
Parts Used Fresh root
Role in Chai Hu Gui Zhi Tang

Warms the Middle Burner, assists Ban Xia in stopping nausea, and helps Gui Zhi release the exterior. Also harmonizes the Stomach to support digestion of the formula's herbs.

Da Zao
Da Zao

Jujube dates

Dosage: 6 pieces

Temperature Warm
Taste Sweet
Organ Affinity Spleen, Stomach
Parts Used Dried ripe fruit
Role in Chai Hu Gui Zhi Tang

Nourishes the Spleen and Stomach, generates fluids, and moderates the harshness of the formula's other herbs. Paired with Sheng Jiang, it harmonizes the Ying and Wei Qi and helps all the herbs work together smoothly.

Gan Cao
Gan Cao

Liquorice

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Dried root and rhizome
Role in Chai Hu Gui Zhi Tang

Harmonizes all the herbs in the formula, tonifies Spleen Qi, and generates fluids. Its sweet flavor moderates the formula's dispersing and clearing actions and helps protect the Middle Burner.

Modern Research (3 studies)

  • Preventive effects of Chai-hu-gui-zhi-tang extract on stress-induced gastric ulceration in rats (Animal study, 2010)
  • Suppression by Chai-hu-gui-zhi-tang of liver lesions induced by N-nitrosomorpholine in rats (Animal study, 2000)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Take warm, 30 minutes before meals or between meals, twice or three times daily. For acute exterior conditions, taking with a small bowl of warm rice porridge after each dose is traditionally recommended.

Typical Duration

Acute use (exterior patterns, colds): 3-7 days. Chronic conditions (gastric pain, joint pain, neurological issues): 2-4 weeks, reassessed by a practitioner.

Dietary Advice

Avoid cold, raw foods, iced drinks, and greasy or heavy foods while taking this formula, as these may impair the Spleen and Stomach's digestive function and obstruct the formula's harmonizing action. Alcohol, spicy, and strongly flavored foods should also be avoided. The classical instruction for Gui Zhi Tang included eating a small bowl of warm thin rice porridge (热稀粥) after taking the decoction to help support the Stomach Qi and assist the formula in generating a mild sweat. Light, warm, easily digestible foods such as congee, steamed vegetables, and simple soups are ideal. Do not take tonifying or enriching herbal supplements concurrently.

Modern Usage

Chai Hu Gui Zhi Tang, a combined formula of Xiao Chai Hu Tang and Gui Zhi Tang, was originally designed to treat concurrent Tai Yang (Great Yang) and Shao Yang (Lesser Yang) syndromes. It possesses both the function of harmonizing and resolving Shao Yang while also releasing the muscle layer to expel the Exterior pathogen, making it effective for treating diseases involving both the Tai Yang and Shao Yang channels.

Additionally, it can harmonize the Nutritive and Defensive levels and regulate Qi and Blood internally, thus treating various internal and external conditions where the channels of 4 levels (Nutritive, Defensive, Qi and Blood) are obstructed.

Clinically, it is often used to treat conditions with concurrent Tai Yang and Shao Yang involvement, such as fever, cough, asthma, chest and hypochondriac pain, epigastric pain, vomiting, arthralgia, and edema. There are also reports of its use in treating epilepsy, nocturnal enuresis, cholelithiasis (gallstones), cholecystitis, hepatitis, pancreatitis, vertigo, pleurisy, intercostal neuralgia, gastric and duodenal ulcers, acute pyelonephritis, mild epidemic hemorrhagic fever, chronic sinusitis, urticaria (hives), postpartum fever, fever of unknown origin, pediatric orthostatic dysregulation, and pediatric anorexia, especially in cases involving both Shao Yang and Tai Yang patterns.

Special Populations

Pregnancy

Use with caution during pregnancy and only under practitioner guidance. Gui Zhi (Cinnamomi Ramulus) has a warm, acrid nature that promotes circulation of Qi and Blood, which theoretically could increase uterine activity. Ban Xia (Pinelliae Rhizoma) is traditionally classified as cautioned during pregnancy due to its drying and descending properties, though the processed form (Fa Ban Xia) used in standard practice carries less risk. Chai Hu's ascending and dispersing properties also warrant care. While the formula uses half-doses of all ingredients (reducing these concerns), pregnant women should not self-prescribe and should consult a qualified practitioner who can assess the individual situation.

Breastfeeding

Generally considered compatible with breastfeeding when used under practitioner supervision at standard doses. The formula is mild in nature (half-doses of its parent formulas) and primarily contains food-grade herbs (Sheng Jiang, Da Zao, Gan Cao). However, the aromatic and dispersing properties of Gui Zhi and Chai Hu may theoretically pass into breast milk in small amounts. Ban Xia's drying properties could potentially reduce milk production in some individuals. No significant adverse effects on nursing infants have been documented, but as a precaution, breastfeeding mothers should use this formula only as prescribed and monitor for any changes in milk supply or infant feeding behavior.

Pediatric Use

Chai Hu Gui Zhi Tang can be used in children, but dosage must be reduced according to age and body weight. As a general guideline, children aged 6-12 may take one-half to two-thirds of the adult dose, while children aged 2-5 should receive one-quarter to one-third. Infants under 2 require specialist assessment. The formula has been used clinically in Japan (as Saiko-Keishi-To / TJ-10) for pediatric conditions including recurrent upper respiratory infections in immunocompromised children, with reported improvements in fever, appetite, and cold frequency. All pediatric use should be supervised by a qualified practitioner. Children must take the formula under adult supervision.

Drug Interactions

Gan Cao (Licorice root) in this formula contains glycyrrhizin, which can cause potassium depletion and sodium retention with prolonged use. This creates potential interactions with:

  • Antihypertensive medications: Glycyrrhizin may counteract blood pressure-lowering effects through sodium and water retention.
  • Diuretics (especially thiazides and loop diuretics): Combined potassium loss may increase the risk of hypokalemia.
  • Cardiac glycosides (e.g. digoxin): Hypokalemia from Gan Cao can potentiate digoxin toxicity.
  • Corticosteroids: Glycyrrhizin inhibits the enzyme that inactivates cortisol, potentially amplifying steroid effects.

Chai Hu (Bupleurum) contains saikosaponins that may affect hepatic cytochrome P450 enzymes. Patients taking medications with narrow therapeutic windows that are metabolized by the liver (such as warfarin, cyclosporine, or certain anticonvulsants) should use this formula with medical supervision, as herb-drug interactions affecting drug metabolism are possible.

Gui Zhi (Cinnamon twig) has mild blood-moving properties and could theoretically enhance the effects of anticoagulant or antiplatelet medications, though this interaction is not well documented at the low doses used in this formula.

Contraindications

Caution

Pure interior excess Heat patterns (Yang Ming stage) without any exterior or half-exterior component. This formula contains warming herbs (Gui Zhi, Sheng Jiang) that would aggravate interior Heat.

Caution

Yin deficiency with deficiency Heat (signs such as night sweats, malar flush, dry mouth at night, red tongue with little coating). The warm, dispersing nature of Gui Zhi and the drying nature of Ban Xia may further deplete Yin fluids.

Caution

Patients with high fever above 38.5°C (101.3°F) should seek emergency medical evaluation rather than relying on this mild-acting formula.

Caution

Should not be combined with tonifying or enriching herbal medicines during the course of treatment, as this may interfere with the formula's exterior-releasing and harmonizing actions.

Caution

Pure Wind-Cold exterior excess pattern with strong chills, no sweating, and no Shaoyang symptoms (no nausea, no chest/rib-side discomfort). A stronger exterior-releasing formula would be more appropriate.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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