Zi Yun Gao

Purple Cloud Ointment · 紫云膏

Also known as: Run Ji Gao (润肌膏, Flesh-Moistening Ointment), Zi Cao Gao (紫草膏, Lithospermum Ointment), Shiunko (紫云膏, Japanese Kampo name)

A classical topical ointment used for minor skin problems including burns, cuts, eczema, insect bites, cracked skin, and frostbite. It cools inflamed skin, promotes tissue repair, and moisturizes dry or damaged areas. Made from just a few natural ingredients infused in sesame oil, it has been a household skin remedy in East Asia for over 400 years.

Origin Wài Kē Zhèng Zōng (《外科正宗》, True Lineage of External Medicine) by Chén Shí Gōng (陈实功), originally recorded as Rùn Jī Gāo (润肌膏, Flesh-Moistening Ointment) — Ming dynasty, 1617 CE
Composition 2 herbs
Zi Cao
King
Zi Cao
Dang Gui
Deputy
Dang Gui
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zi Yun Gao is designed to correct these specific patterns.

Why Zi Yun Gao addresses this pattern

When Heat-Toxin accumulates in the skin and superficial flesh, it manifests as red, swollen, hot, and painful lesions. This can result from burns (fire or hot water), infected wounds, or inflammatory skin conditions. Zi Yun Gao addresses this directly: Zi Cao, the King herb, is classified as a Heat-clearing, Blood-cooling medicinal that resolves Toxins. Applied topically, it cools the local Heat, neutralizes Toxins, and inhibits bacterial growth. Dang Gui supports recovery by moving Blood out of stasis and nourishing new tissue growth. Together in a sesame oil base, they clear inflammation while promoting repair.

A practitioner would look for one or more of these signs

Burns

Minor burns with redness, pain, and blistering

Skin Ulcers

Wounds that are slow to heal with local redness and swelling

Skin Infection

Superficial infected lesions

Insect Bites

Red, swollen, itchy bites

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zi Yun Gao when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Dryness with skin manifestations Heat-Toxin affecting the skin

TCM Interpretation

In TCM, chronic eczema (often called 'Damp sores' or 'skin wind') frequently involves an interplay of Wind, Dampness, and Heat in the acute phase, evolving into Blood Deficiency and Blood Dryness in the chronic phase. When the skin becomes dry, rough, thickened, and itchy without much oozing, the primary problem has shifted to inadequate Blood nourishment of the skin. The skin essentially starves for moisture from within. Residual Heat may still linger, causing intermittent redness and itching.

Why Zi Yun Gao Helps

Zi Yun Gao is best suited for the dry, non-oozing phase of eczema. Zi Cao cools residual Heat in the skin and has demonstrated anti-inflammatory effects through its shikonin content. Dang Gui nourishes Blood and improves local circulation, helping the skin recover its moisture and integrity. The sesame oil base provides direct lubrication and creates a protective barrier. For eczema with significant oozing or weeping, this ointment is less appropriate, as the oily base can trap moisture and worsen the condition. Practitioners may recommend the modified 'Zi Huang Gao' version (which adds Huang Lian, Huang Qin, Huang Bai, and Da Huang) for more inflammatory, Damp-Heat presentations.

Also commonly used for

Dermatitis

Contact dermatitis and dry dermatitis

Skin Ulcers

Minor wounds and superficial ulcerations slow to heal

Frostbite

Mild frostbite and chilblains

Psoriasis

Dry, scaly psoriatic plaques as supportive care

Acne

Inflammatory acne lesions

Diaper Rash

Infant diaper rash

Hemorrhoids

External hemorrhoids with irritation

Insect Bites

Mosquito and insect bites with swelling and itch

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zi Yun Gao does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zi Yun Gao is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zi Yun Gao performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zi Yun Gao works at the root level.

Zi Yun Gao addresses a straightforward external pathomechanism: when the skin is damaged by burns, trauma, insect bites, or exposure to harsh conditions, Heat and Toxins accumulate locally in the flesh and skin. In TCM terms, fire, hot liquid, or external pathogens injure the local tissues, causing Heat-Toxin to lodge in the skin and superficial flesh layers. This Heat scorches the local Blood vessels, leading to redness, swelling, and pain.

At the same time, the damaged area develops Blood stasis, since injured tissue disrupts normal circulation. This stasis prevents fresh Blood from nourishing the area, slowing healing and potentially leading to dead tissue. In chronic cases or with dry skin conditions like eczema and cracked hands, the picture shifts toward Blood Deficiency and dryness: without adequate Blood and moisture reaching the skin, it becomes rough, itchy, flaky, and prone to cracking.

The formula therefore needs to accomplish two things at once: clear the Heat-Toxin that causes inflammation and infection, and nourish and move the Blood so that new, healthy tissue can grow. The sesame oil base itself contributes by moisturizing the skin and serving as a vehicle to deliver the medicinal compounds directly to the affected area.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly oily and slightly sweet from the sesame oil and Dang Gui, with a mild bitter note from the Zi Cao. As a topical ointment, taste is not clinically relevant.

Target Organs

Channels Entered

Ingredients

2 herbs

The herbs that make up Zi Yun Gao, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Zi Cao

Zi Cao

Gromwell root

Dosage 3 - 10g
Temperature Cold
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Heart, Liver
Preparation Infused in heated sesame oil until the oil turns deep purple-red. Must not be overcooked or the color darkens and active compounds degrade.

Role in Zi Yun Gao

The principal medicinal herb. Zi Cao (lithospermum/arnebia root) clears Heat, cools the Blood, and resolves Toxins. Applied topically, it has strong anti-inflammatory and antimicrobial actions, promotes tissue regeneration, and gives the ointment its characteristic purple-red color. It addresses the core pathomechanism of Heat-Toxin lodged in the skin.
Deputy — Assists and enhances the King
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 15g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Preparation Added to sesame oil first and fried until lightly browned before the Zi Cao is added, to fully extract its fat-soluble active compounds.

Role in Zi Yun Gao

Dang Gui (Chinese angelica root) nourishes and activates Blood, reduces swelling, relieves pain, and promotes the formation of new tissue (granulation). It complements Zi Cao by addressing the Blood stasis component of skin lesions and providing moisture to dry, cracked skin.

Why This Combination Works

How the herbs in Zi Yun Gao complement each other

Overall strategy

The formula pairs a Heat-clearing, Toxin-resolving herb with a Blood-nourishing, Blood-moving herb, delivered in a sesame oil and beeswax base that both moisturizes damaged skin and extracts the fat-soluble active compounds from the herbs. This two-pronged approach addresses both the inflammatory (Heat-Toxin) and the circulatory (Blood stasis and Blood Deficiency) components of skin damage simultaneously.

King herbs

Zi Cao (lithospermum or arnebia root) is the King herb and the formula's namesake. It clears Heat, cools the Blood, and resolves Toxins, directly targeting the inflammation, redness, and potential infection at the wound site. Its active compound shikonin has demonstrated anti-inflammatory and broad-spectrum antimicrobial properties. It also promotes the shedding of necrotic tissue and stimulates new cell growth.

Deputy herbs

Dang Gui (Chinese angelica root) serves as Deputy, reinforcing the King from a complementary angle. While Zi Cao focuses on clearing pathogenic Heat, Dang Gui nourishes and activates the Blood, improving local circulation to deliver nutrients to the healing tissue. It promotes granulation (new flesh formation), relieves pain, reduces swelling, and moisturizes dry skin. Its ferulic acid content supports new blood vessel formation in healing wounds.

Notable synergies

The Zi Cao and Dang Gui pairing is the heart of this formula. Zi Cao clears what should not be there (Heat, Toxins, dead tissue) while Dang Gui builds what needs to be there (fresh Blood, new tissue, moisture). The sesame oil acts as more than a passive vehicle: it has its own skin-moisturizing and mildly analgesic properties, and its lipid base is ideal for extracting the fat-soluble active compounds from both herbs. The beeswax provides structure to the ointment and adds its own mild tissue-protective and pain-relieving qualities.

How to Prepare

Traditional preparation instructions for Zi Yun Gao

Classical Method (Oil-Extraction Ointment)

The original method from the Wài Kē Zhèng Zōng is an oil-infusion technique. Sesame oil (胡麻油, Hú Má Yóu) is the base, serving as both solvent and vehicle to extract the fat-soluble active compounds from the herbs.

  1. Infuse the Dang Gui: Heat approximately 200 ml of sesame oil in a stainless steel or ceramic pot. Add sliced Dang Gui (当归, about 15–20 g) and fry on low-medium heat until the herb turns dark brown and slightly charred. Remove the Dang Gui residue with a strainer.
  2. Infuse the Zi Cao: Add Zi Cao (紫草, about 10–15 g) to the hot oil and simmer gently for 2–3 minutes. The oil will quickly turn a deep purple-red. Strain out the Zi Cao residue immediately (over-cooking destroys the active shikonin compounds).
  3. Add the beeswax: Reheat the strained, now-purple oil. Add yellow beeswax (黄蜡, about 30–50 g per 200 ml oil; adjust for desired firmness: less wax for softer ointment in winter, more for summer). Stir until fully melted and blended.
  4. Pour and cool: Pour the mixture into clean porcelain or glass containers. Allow to cool undisturbed at room temperature until it solidifies into a semi-solid, deep purple-red ointment.

Store in a sealed container, away from light and heat. Refrigeration extends shelf life. The ointment will stain fabric and skin purple-red.

Common Modifications

How practitioners adapt Zi Yun Gao for specific situations

Added
Huang Lian

9g, clears Heat and dries Dampness

Huang Qin

9g, clears Heat and dries Dampness

9g, clears Heat and dries Dampness from the Lower Jiao
Da Huang

9g, clears Heat-Toxin and reduces swelling

This modification creates 'Zi Huang Gao' (紫黄膏), adding four strongly Heat-clearing, Dampness-drying herbs to handle weeping, inflamed lesions where Damp-Heat is prominent. The standard Zi Yun Gao is better for dry-type conditions, while this version suits red, oozing rashes like acute eczema or diaper rash with papules and vesicles.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zi Yun Gao should not be used or requires extra caution

Caution

Open, weeping wounds with heavy exudation or pus. The oily, occlusive nature of the ointment can trap moisture and worsen infection in wounds that are actively oozing or producing large amounts of discharge. A modified formula (such as Zi Huang Gao, which adds bitter-cold herbs) is more appropriate for such cases.

Avoid

Known allergy to sesame (sesame oil is the primary base). Individuals with sesame allergy may develop contact dermatitis or more serious allergic reactions upon application.

Avoid

Deep or severe (third-degree) burns, or large open wounds requiring medical attention. Zi Yun Gao is suitable for minor (first- and second-degree) burns and small wounds only. Severe injuries require professional medical treatment.

Avoid

Wounds with active heavy bleeding. While the ointment may help minor oozing, actively hemorrhaging wounds need direct pressure and medical intervention, not topical herbal ointment.

Caution

Individuals with G6PD deficiency (favism) should avoid formulations that contain added borneol (Bing Pian), as borneol can trigger hemolytic reactions in these patients. The classical formula without borneol is generally safe, but many modern variants include it.

Caution

Severely infected wounds requiring systemic antibiotics. While Zi Yun Gao has mild antibacterial properties, it is not a substitute for proper medical treatment of serious skin infections with cellulitis, abscess formation, or systemic signs of infection.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

The standard Zi Yun Gao formula (containing only Zi Cao, Dang Gui, sesame oil, and beeswax) is an external ointment made entirely from food-grade ingredients and is generally considered safe for topical use during pregnancy for minor skin issues. However, some modern variants add borneol (Bing Pian, 冰片), which is contraindicated in pregnancy as it may stimulate uterine contractions and has been reported to potentially cause miscarriage. Pregnant women should verify the formula does not contain borneol or other added ingredients before use. When in doubt, consult a qualified practitioner.

Breastfeeding

Zi Yun Gao is an external ointment applied to the skin, not taken internally. Its ingredients (Zi Cao, Dang Gui, sesame oil, beeswax) are all natural, food-grade substances with minimal systemic absorption. It is generally considered safe during breastfeeding for topical use on the body. Avoid applying the ointment directly on or near the nipple or areola area, as the infant could ingest it during nursing. While the ingredients are non-toxic even if accidentally ingested in small amounts, the deep purple pigment can stain skin and clothing. If treating cracked nipples, thoroughly clean the area before breastfeeding.

Children

Zi Yun Gao is widely regarded as one of the gentlest topical herbal preparations and is commonly used in children, including infants. Its ingredients are all natural and food-grade, so accidental ingestion of small amounts is not considered dangerous. It is frequently used for diaper rash (nappy rash) in babies, insect bites, minor scrapes, and mild eczema in children. Apply a thin layer to the affected area. As with any topical product, test a small amount on a patch of skin first to check for any allergic reaction before wider application. Note: Do not confuse Chinese Zi Yun Gao (made from Zi Cao root, Lithospermum erythrorhizon) with Western comfrey-based ointments (also sometimes called "purple balm"), which contain pyrrolizidine alkaloids with liver toxicity and are not suitable for children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zi Yun Gao

As a topical ointment that is not taken internally, Zi Yun Gao has very limited systemic absorption and therefore minimal risk of systemic drug interactions.

Potential considerations:

  • Topical medications: Do not apply Zi Yun Gao simultaneously with other topical preparations (such as corticosteroid creams, antibiotic ointments, or antifungal creams) on the same area without practitioner guidance. The oily base may alter absorption of other topical drugs, and chemical interactions are unpredictable.
  • Povidone-iodine and antiseptics: Research suggests that the mechanism of Zi Yun Gao may differ from and potentially conflict with conventional antiseptics. Clean any previously applied antiseptic from the wound before applying Zi Yun Gao.
  • Anticoagulant medications: Dang Gui has known blood-activating properties. While systemic absorption from topical application is minimal, as a precaution, individuals on anticoagulant therapy (warfarin, heparin) should avoid applying Zi Yun Gao to large wound areas or broken skin where absorption could be enhanced.

Usage Guidance

Practical advice for getting the most out of Zi Yun Gao

Best time to take

Apply after cleaning the affected area. For chronic skin conditions, applying at bedtime (covering with gauze overnight and washing off in the morning) allows extended contact time during sleep.

Typical duration

Applied externally 2–3 times daily until the skin condition resolves. For minor wounds and burns: typically 3–14 days. For chronic skin conditions like eczema: may be used intermittently for weeks as needed.

Dietary advice

As an external ointment, Zi Yun Gao does not require significant dietary modification. However, when using it for burn treatment, classical practice recommends avoiding spicy, greasy, and heavily flavored foods, as these can generate internal Heat and impede skin healing. For eczema-related use, reducing intake of shellfish, alcohol, and heavily processed foods may support the healing process. No specific food prohibitions apply for minor wound care or insect bites.

Zi Yun Gao originates from Wài Kē Zhèng Zōng (《外科正宗》, True Lineage of External Medicine) by Chén Shí Gōng (陈实功), originally recorded as Rùn Jī Gāo (润肌膏, Flesh-Moistening Ointment) Ming dynasty, 1617 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zi Yun Gao and its clinical use

《外科正宗》(Wài Kē Zhèng Zōng) by Chén Shí Gōng, on the original "Run Ji Gao" (润肌膏, Flesh-Moistening Ointment):

「润肌膏内用麻油,紫草当归一处投,能搽秃疮枯槁色,加之黄蜡效应收。」

"The Flesh-Moistening Ointment uses sesame oil within; Zi Cao and Dang Gui are combined together. It can be applied to bald sores with a withered appearance; add yellow beeswax and it will achieve its effect."

The same text also praised the formula with:

「乃外科收敛药中之神药。」

"This is a miraculous remedy among the astringent medicines of external medicine."

Historical Context

How Zi Yun Gao evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zi Yun Gao has a fascinating cross-cultural history spanning China and Japan. The formula originates from the Ming dynasty physician Chén Shí Gōng (陈实功, 1555–1636), who recorded it in his landmark surgical text Wài Kē Zhèng Zōng (《外科正宗》, True Lineage of External Medicine), published in 1617. In the original text, the ointment was called Rùn Jī Gāo (润肌膏, "Flesh-Moistening Ointment") and appeared in the chapter on bald sores (白秃疮), a fungal scalp condition in children. The original composition was simple: sesame oil, Dang Gui, Zi Cao, and yellow beeswax.

The formula later traveled to Japan, where it was adopted and refined during the Edo period (1603–1868) by the celebrated surgeon Hanaoka Seishū (华冈青洲, 1760–1835), often regarded as the first physician in the world to perform surgery under general anesthesia. Hanaoka modified the preparation method (adding lard to improve consistency) and renamed it Shiunko (紫云膏, "Purple Cloud Ointment"), recording it in his text Shunrinken Kōhō Benran (《春林轩膏方便览》). Under this name, it became one of the most widely used topical Kampo preparations in Japan, eventually gaining inclusion in the Japanese Pharmacopoeia.

Today, Zi Yun Gao is popular across East Asia as a household remedy. Its gentle, all-natural composition has made it a favorite for home preparation, and it is widely used for everything from minor burns and cuts to eczema and insect bites.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Zi Yun Gao

1

Shiunko Promotes Epithelization of Wounded Skin (Animal Study, 2004)

Huang MH, et al. American Journal of Chinese Medicine, 2004, 32(3), 389–396.

This animal study tested Shiunko (Zi Yun Gao) on experimentally induced skin wounds in rats, comparing it with povidone-iodine and saline. Wounds treated with Shiunko showed 0% infection rate after Pseudomonas inoculation (vs. 40% for saline) and 100% complete re-epithelialization on sterile wounds. The study concluded that Shiunko promoted epithelialization of wounded skin, while povidone-iodine did not.

PubMed
2

Shiunko and Acetylshikonin Promote Reepithelialization, Angiogenesis, and Granulation Tissue Formation in Wounded Skin (Animal Study, 2008)

Lu L, et al. American Journal of Chinese Medicine, 2008, 36(1), 115–126.

This rat wound model study compared Shiunko and its active compound acetylshikonin against gentamicin and silver sulfadiazine ointments. Both Shiunko and acetylshikonin showed significantly higher rates of re-epithelialization on both sterile and infected wounds compared to the conventional disinfectants. Histological analysis confirmed greater angiogenesis and granulation tissue formation.

PubMed
3

Efficacy of Shiunko for the Treatment of Atopic Dermatitis (Clinical Study, 1999)

Hayashi I, et al. Journal of Dermatology, 1999, 26(4), 235–241.

In this small clinical study, Shiunko was applied to atopic dermatitis patients and compared with white petrolatum and salt water. Shiunko was clinically effective in 57% of patients (4 of 7), compared with 0% for petrolatum and 14% for salt water. Bacterial counts, particularly Staphylococcus aureus, were also reduced, suggesting antibacterial benefits relevant to eczema management.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.