Zhi Zi Bo Pi Tang

Gardenia and Phellodendron Bark Decoction · 栀子柏皮汤

Also known as: Bo Pi Tang (柏皮汤, Phellodendron Bark Decoction), Bo Pi San (柏皮散, Phellodendron Bark Powder)

A classical formula for damp-heat jaundice with heat predominating, used to reduce yellowing of the skin and eyes, relieve fever, and clear dark urine by draining damp-heat from the Liver and Gallbladder.

Origin Shang Han Lun (伤寒论) — Eastern Han dynasty, ~200 CE
Composition 3 herbs
Zhi Zi
King
Zhi Zi
Huang Bo
Deputy
Huang Bo
Gan Cao
Assistant/Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhi Zi Bo Pi Tang is designed to correct these specific patterns.

Why Zhi Zi Bo Pi Tang addresses this pattern

This formula is a classical choice for damp-heat in the Liver and Gallbladder manifesting as jaundice with heat predominating. The bitter-cold combination clears the Liver's damp-heat, drains dampness via urine, and abates jaundice. Zhi Zi clears the three jiao and promotes urination to expel dampness, Huang Bo dries dampness and clears heat, and Gan Cao harmonizes. It is particularly suited when the patient has fever, yellow body, dark urine, and a red tongue with yellow greasy coating, but without significant abdominal distension or constipation.

A practitioner would look for one or more of these signs

Jaundice

yellow skin and sclera

Fever

low-grade or moderate fever, possibly afternoon

Dark Urine

scanty, dark yellow or reddish urine

Red Tongue With Yellow Greasy Coating

tongue body red, coating yellow and greasy

Irritability

restlessness and feeling of heat

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zhi Zi Bo Pi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acute icteric hepatitis is often seen as an invasion of damp-heat into the Liver and Gallbladder. The dampness and heat combine, impeding the Liver's function of free coursing and the Gallbladder's secretion of bile, causing bile to overflow into the skin and manifest as jaundice. Heat predominating leads to fever, dark urine, and a red tongue. The presence of dampness causes a greasy tongue coating and possible nausea.

Why Zhi Zi Bo Pi Tang Helps

Gardenia and Phellodendron Bark Decoction directly targets damp-heat in the Liver and Gallbladder. Zhi Zi (Gardenia) clears heat from all three jiao and promotes urination to drain dampness, while Huang Bo (Phellodendron) focuses on clearing damp-heat from the lower burner and drying dampness. Together they reduce liver inflammation, normalize bile flow, and lower jaundice levels. Honey-fried licorice protects the stomach from the bitter-cold herbs, making it suitable even when the patient has a poor appetite.

Also commonly used for

Cholecystitis

Clears damp-heat to relieve gallbladder inflammation and associated pain.

Severe Hepatitis

Assists in clearing intense damp-heat to protect liver function.

Pancreatitis

Clears heat and dampness that contribute to pancreatic inflammation.

Acne

Clears damp-heat from the skin, especially when acne is red and inflamed with oily skin.

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zhi Zi Bo Pi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zhi Zi Bo Pi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zhi Zi Bo Pi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zhi Zi Bo Pi Tang works at the root level.

This formula addresses damp-heat accumulating internally with heat predominating. The damp-heat steams in the Liver and Gallbladder, causing the gallbladder qi to overflow and leading to jaundice (yellow skin and eyes). The heat is relatively strong, producing fever, while the dampness is mild, so there is no significant abdominal distension or constipation. The damp-heat pours down, causing dark, scanty urine. The tongue body is red and the coating yellow and greasy.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter with sweet — bitter to drain heat and dry dampness, sweet to harmonize and protect the middle.

Target Organs

Channels Entered

Heart San Jiao Kidney Bladder Spleen Stomach

Ingredients

3 herbs

The herbs that make up Zhi Zi Bo Pi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 10 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Preparation cracked (劈)

Role in Zhi Zi Bo Pi Tang

Clears heat from all three jiao, drains dampness by promoting urination, abates jaundice, cools blood and resolves toxins.
Deputy — Assists and enhances the King
Huang Bo

Huang Bo

Phellodendron bark

Dosage 6 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Kidneys, Urinary Bladder

Role in Zhi Zi Bo Pi Tang

Clears heat and dries dampness, drains fire and resolves toxins, especially clears damp-heat from the lower burner.

Why This Combination Works

How the herbs in Zhi Zi Bo Pi Tang complement each other

Overall strategy

This formula clears heat and drains dampness to abate jaundice. It targets damp-heat jaundice where heat predominates, focusing on clearing heat from all three jiao, particularly the lower burner.

King herbs

Zhi Zi (Gardenia) is the king herb. Bitter and cold, it enters the Heart, Lung, and Triple Burner meridians. It clears heat from all three jiao, drains dampness by promoting urination, abates jaundice, and cools the blood to resolve toxins. It directly addresses the damp-heat steaming and jaundice.

Deputy herbs

Huang Bo (Phellodendron bark) is the deputy. Bitter and cold, it enters the Kidney, Bladder, and Large Intestine meridians. It excels at clearing damp-heat from the lower burner, drying dampness, and draining fire. It reinforces the heat-clearing and dampness-draining action, especially targeting the lower burner where damp-heat often collects.

Assistant and Envoy herbs

Zhi Gan Cao (honey-fried licorice) serves as both assistant and envoy. Its sweet and neutral nature harmonizes the formula, supplements the middle qi, and moderates the bitter cold nature of Zhi Zi and Huang Bo to protect the stomach. Its sweet flavor also helps anchor the herbs in the middle burner to guide the heat-clearing and dampness-draining action.

Notable synergies

The combination of Zhi Zi and Huang Bo creates a potent clearing effect on damp-heat, with Zhi Zi addressing the upper and middle jiao and Huang Bo focusing on the lower jiao. Together they provide comprehensive clearing of damp-heat throughout the body.

How to Prepare

Traditional preparation instructions for Zhi Zi Bo Pi Tang

Take the three ingredients, add 4 sheng of water (approximately 800 mL), decoct down to 1.5 sheng (approximately 300 mL). Remove the dregs and divide into two doses to be taken warm. Modern equivalent: decoct with 400 mL water to obtain about 250 mL, divide into two doses.

Common Modifications

How practitioners adapt Zhi Zi Bo Pi Tang for specific situations

Added
Da Huang

Sheng Da Huang (生大黄) 6-9g, to drain heat and unblock the bowels

Zhi Shi

Zhi Shi (枳实) 6-9g, to break stagnation and promote bowel movement

Adding Da Huang and Zhi Shi adds a purgative action to clear heat accumulation from the bowels, which helps to discharge damp-heat and eliminate jaundice more quickly.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zhi Zi Bo Pi Tang should not be used or requires extra caution

Caution

Not suitable for early-stage jaundice accompanied by exterior syndrome; resolve the exterior first.

Caution

Not suitable for yang jaundice where dampness predominates over heat; combine with dampness-transforming herbs.

Caution

Use with caution in Spleen-Stomach deficiency cold with diarrhea, poor appetite, or cold limbs.

Avoid

Contraindicated in cold-damp jaundice (dull yellow color, aversion to cold, pale tongue with white greasy coating).

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Caution advised — contains bitter-cold herbs (Zhi Zi, Huang Bai) that may stimulate uterine contractions or affect fetal development. Use only under strict practitioner guidance when absolutely necessary.

Breastfeeding

No specific data on breast milk transfer exists for the herbs in this formula. Due to the bitter-cold nature of Zhi Zi and Huang Bai, which may affect the infant's digestion, caution is advised. Use only under practitioner guidance.

Children

Dosage should be reduced to 1/2 to 1/3 of the adult dose, typically Zhi Zi 3–5 g, Huang Bai 2–3 g, Zhi Gan Cao 1–1.5 g, decocted and taken in two divided doses. Use only under practitioner supervision and for confirmed damp-heat patterns.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zhi Zi Bo Pi Tang

Theoretically, Zhi Zi and Huang Bai in this formula may interact with certain medications:

  • Antihypertensives and diuretics: Gan Cao (licorice) can cause sodium retention and potassium loss, potentially counteracting antihypertensive effects or increasing risk of digoxin toxicity.
  • Corticosteroids: Gan Cao may potentiate corticosteroid effects.
  • Sedatives and beta-blockers: Zhi Zi may potentiate sedation or affect blood pressure; use caution with anesthetics, beta-blockers, and atropine.
  • CYP450 substrates: Huang Bai alkaloids (e.g., berberine) may inhibit CYP3A4 and CYP2D6, potentially increasing blood levels of drugs metabolized by these enzymes (e.g., statins, calcium channel blockers).

No well-documented clinical interaction studies exist specifically for this formula. Consult a healthcare provider before concurrent use with prescription medications.

Usage Guidance

Practical advice for getting the most out of Zhi Zi Bo Pi Tang

Best time to take

Best taken after meals to minimize stomach irritation from the bitter-cold herbs.

Typical duration

Typically prescribed for 1–2 weeks for acute jaundice; may be extended under practitioner guidance for chronic conditions.

Dietary advice

Avoid spicy, greasy, raw, and cold foods. Avoid alcohol. Favor light, easily digestible foods to support Spleen-Stomach function.

Zhi Zi Bo Pi Tang originates from Shang Han Lun (伤寒论) Eastern Han dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zhi Zi Bo Pi Tang and its clinical use

《伤寒论》:伤寒身黄发热,栀子柏皮汤主之。
Shang Han Lun: In cold damage with generalized yellowing and fever, Zhi Zi Bai Pi Tang governs.

栀子柏皮汤方:栀子十五个(擘),甘草一两(炙),黄柏二两。上三味,以水四升,煮取一升半,去滓,分温再服。
Zhi Zi Bai Pi Tang formula: Zhi Zi (Gardenia) fifteen pieces (split), Gan Cao (Licorice) one liang (fried with honey), Huang Bai (Phellodendron) two liang. The three ingredients are decocted in four sheng of water to one and a half sheng, strained, and taken warm in two doses.

Historical Context

How Zhi Zi Bo Pi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zhi Zi Bai Pi Tang is one of the three classical methods for treating jaundice in the Shang Han Lun, representing the 'clearing' (清) approach, alongside the sweating method (Ma Huang Lian Qiao Chi Xiao Dou Tang) and the purging method (Yin Chen Hao Tang). The renowned physician Liu Duzhou once described initially overlooking this formula until he successfully used it for a teenage boy with hepatitis whose jaundice persisted despite Yin Chen Hao Tang injections; the key indicator was the patient's habit of sleeping with his feet outside the covers due to heat in the soles, reflecting deep-lying heat in the Kidney channel. Liu later emphasized its value in chronic hepatitis with lingering damp-heat and Spleen deficiency, where Yin Chen Hao Tang is too harsh. Some scholars have speculated that the original ingredient Gan Cao might have been a textual error for Yin Chen Hao, but clinical practice has affirmed the three-herb composition's unique role in clearing heat from all three burners while protecting the middle.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Zhi Zi Bo Pi Tang

1

Study on the protective effect in immunological liver injury in mice of Zhizi Baipi Soup and its disassembled prescription (2015)

Yang Y, Wu XQ, Li XF, et al. Chinese Pharmacological Bulletin, 2015, 31(12): 1764-1769.

This study demonstrated that Zhizi Baipi Tang and its Zhi Zi-containing combinations reduced serum ALT, AST, and MDA levels, increased liver SOD activity, and downregulated NF-κB-p65 and NF-κB-p-p65 expression in ConA-induced immunological liver injury mice. The whole formula showed the strongest protective effect, suggesting a mechanism involving immune response regulation via the NF-κB pathway.

DOI
2

Research progress on chemical constituents, pharmacological effects and predictive analysis of quality markers of Zhizi Baipi Decoction (2026)

Tan YL, Chen YX, Han YG. West China Journal of Pharmaceutical Sciences, 2026, 41(1): 124-130.

This review summarized the chemical composition and pharmacological actions of Zhizi Baipi Tang, identifying potential quality markers such as geniposide, berberine, phellodendrine, liquiritin, glycyrrhizic acid, gardenic acid, crocin I, and glycyrrhetinic acid. The formula's main effects include hepatoprotection, cholagogic action, anti-inflammation, and anti-fibrosis, with applications in immunological liver injury, intrahepatic cholestasis, and liver fibrosis.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.