Zhi Shi Xie Bai Gui Zhi Tang

Immature Bitter Orange, Chinese Chive, and Cinnamon Twig Decoction · 枳实薤白桂枝汤

A classical formula from the Jin Gui Yao Lue used to treat chest pain, stuffiness, and shortness of breath caused by weakness of chest yang and accumulation of phlegm. It warms and unblocks the chest, dissolves phlegm, and moves stagnant qi to relieve discomfort.

Origin Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing — Han dynasty, ~200 CE
Composition 5 herbs
Gua Lou
King
Gua Lou
Xie Bai
Deputy
Xie Bai
Zhi Shi
Assistant
Zhi Shi
Hou Po
Assistant
Hou Po
Gui Zhi
Assistant
Gui Zhi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhi Shi Xie Bai Gui Zhi Tang is designed to correct these specific patterns.

Why Zhi Shi Xie Bai Gui Zhi Tang addresses this pattern

When phlegm turbidity lodges in the chest, it obstructs the free flow of qi and blood, causing pain, fullness, and shortness of breath. This formula directly dissolves phlegm with Gua Lou, unblocks yang with Xie Bai and Gui Zhi, and descends qi with Zhi Shi and Hou Po, thereby clearing the phlegm obstruction and restoring chest yang.

A practitioner would look for one or more of these signs

Chest Pain

Chest pain that may radiate to the back

Shortness Of Breath

Shortness of breath, especially on exertion

Cough

Cough with copious white sputum

Expectoration

Expectoration of thick, white phlegm

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zhi Shi Xie Bai Gui Zhi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, coronary heart disease often falls under the category of chest impediment (胸痹). It is frequently caused by deficiency of chest yang with internal obstruction of phlegm turbidity. When yang qi is insufficient, the heart vessels lack warmth and propulsion, allowing phlegm and stagnant qi to block the chest, leading to pain, pressure, and breathlessness.

Why Zhi Shi Xie Bai Gui Zhi Tang Helps

This formula directly targets the root yang deficiency by warming and unblocking chest yang with Xie Bai and Gui Zhi. It dissolves the phlegm obstruction with Gua Lou and descends rebellious qi with Zhi Shi and Hou Po. By clearing the phlegm and moving qi, it restores the free flow of qi and blood in the heart vessels, thereby relieving angina and improving cardiac function.

Also commonly used for

Myocardial Infarction

Used as adjunct therapy to improve chest yang and reduce phlegm obstruction

Chronic Bronchitis

Alleviates cough and phlegm by transforming phlegm and descending lung qi

Intercostal Neuralgia

Eases chest wall pain by moving qi and unblocking yang in the chest

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zhi Shi Xie Bai Gui Zhi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zhi Shi Xie Bai Gui Zhi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zhi Shi Xie Bai Gui Zhi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zhi Shi Xie Bai Gui Zhi Tang works at the root level.

This formula addresses chest impediment (胸痹) caused by deficiency of chest yang (胸阳不振) with internal obstruction of turbid phlegm. When the yang qi in the chest is weak, it fails to warm and propel qi and fluids, allowing yin-cold and turbid phlegm to accumulate and stagnate. The phlegm turbidity obstructs the chest, blocking the free flow of qi and blood, which leads to pain, fullness, and a sensation of stuffiness. Rebellious qi from the lower burner may surge upward, causing a feeling of qi rushing from the hypochondrium to the heart. The key pathomechanism is yang deficiency with yin excess, where the root is yang deficiency and the branch is phlegm turbidity and qi stagnation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly bitter and pungent with some sweetness — bitter to descend and dry, pungent to disperse and move Qi, sweet to harmonize.

Ingredients

5 herbs

The herbs that make up Zhi Shi Xie Bai Gui Zhi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Gua Lou

Gua Lou

Trichosanthes fruit

Dosage 12 - 30g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Stomach, Large Intestine

Role in Zhi Shi Xie Bai Gui Zhi Tang

Opens the chest, dissolves phlegm, and guides out turbid phlegm from the chest to relieve obstruction.
Deputy — Assists and enhances the King
Xie Bai

Xie Bai

Chinese garlic bulb

Dosage 9 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, Stomach, Large Intestine

Role in Zhi Shi Xie Bai Gui Zhi Tang

Unblocks yang qi and disperses clumps, especially in the chest, to relieve pain and stuffiness.
Assistants — Supports or moderates other herbs
Zhi Shi

Zhi Shi

Immature Bitter Orange Fruit

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine

Role in Zhi Shi Xie Bai Gui Zhi Tang

Breaks qi and eliminates stuffiness, assisting in descending turbid phlegm and relieving epigastric and chest fullness.
Hou Po

Hou Po

Magnolia bark

Dosage 9 - 12g
Temperature Warm
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs, Large Intestine

Role in Zhi Shi Xie Bai Gui Zhi Tang

Moves qi, dries dampness, and directs rebellious qi downward, preventing upward counterflow of turbid yin.
Gui Zhi

Gui Zhi

Cinnamon twig

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder

Role in Zhi Shi Xie Bai Gui Zhi Tang

Warms and unblocks yang qi in the chest, assisting Xie Bai to activate chest yang and promote qi circulation.

Why This Combination Works

How the herbs in Zhi Shi Xie Bai Gui Zhi Tang complement each other

Overall strategy

The formula simultaneously warms and unblocks chest yang, dissolves phlegm, and descends rebellious qi to resolve the dual root (yang deficiency) and branch (phlegm obstruction) of chest impediment.

King herbs

Gua Lou (Trichosanthes Fruit) is the primary herb. It is sweet, cold, and lubricating, entering the Lung and Stomach channels. It dissolves thick phlegm, opens the chest, and guides the turbid phlegm downward through the bowels, directly addressing the phlegm obstruction that blocks the chest.

Deputy herbs

Xie Bai (Chinese Chive) is acrid and warm, unblocking yang qi and dispersing clumps. It powerfully activates chest yang and is the key herb for chest bi due to yang deficiency, reinforcing the King herb’s action by warming and moving what is stagnant.

Assistant herbs

Zhi Shi (Immature Bitter Orange) breaks qi and eliminates stuffiness, descending turbid phlegm from the chest and epigastrium. Hou Po (Magnolia Bark) moves qi, dries dampness, and directs rebellious qi downward, preventing the upward surge of turbid yin from the lower burner. Gui Zhi (Cinnamon Twig) warms and unblocks yang qi, assisting Xie Bai to activate chest yang and promote qi circulation, and also helps transform phlegm by warming yang to vaporize fluids.

Notable synergies

The pairing of Gua Lou and Xie Bai is a classic duo for chest impediment: Gua Lou clears the phlegm, Xie Bai unblocks the yang, together opening the chest and relieving pain. Zhi Shi and Hou Po form a powerful qi-moving combination that descends rebellious qi and eliminates fullness, while Gui Zhi and Xie Bai together powerfully warm and unblock chest yang.

How to Prepare

Traditional preparation instructions for Zhi Shi Xie Bai Gui Zhi Tang

First, boil Zhi Shi and Hou Po in 5 cups (about 1000 ml) of water until reduced to 2 cups (about 400 ml). Remove the dregs, then add the remaining herbs (Gua Lou, Xie Bai, Gui Zhi) and bring to a brief boil. Strain and divide into three equal doses, taken warm throughout the day.

Common Modifications

How practitioners adapt Zhi Shi Xie Bai Gui Zhi Tang for specific situations

Added
Dan Shen

9-15g to invigorate blood and relieve pain

Chuan Xiong

6-9g to promote blood circulation and qi flow

Adding blood-invigorating herbs addresses the concurrent blood stasis that often develops when phlegm obstruction and qi stagnation are prolonged.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zhi Shi Xie Bai Gui Zhi Tang should not be used or requires extra caution

Caution

Pregnancy — contains herbs (Zhi Shi, Gui Zhi) traditionally used with caution in pregnancy due to their potential to move Qi and Blood and stimulate uterine contractions. Should only be used under strict professional supervision if the pattern clearly warrants it.

Caution

Deficiency-cold of Spleen and Stomach with weak Qi — the strong Qi-moving and descending nature may aggravate digestive weakness, causing diarrhea or abdominal discomfort.

Caution

Yin deficiency with heat signs — the warming and drying properties may injure Yin fluids and exacerbate heat symptoms.

Caution

Active hemorrhage — the Qi-moving and Blood-invigorating actions may worsen bleeding.

Caution

Chest Bi due to pure Yang deficiency without significant phlegm stagnation — this formula is designed for mixed excess/deficiency with phlegm and Qi stagnation; for pure deficiency, a tonifying approach (e.g., Ren Shen Tang) is more appropriate.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Not recommended during pregnancy without strict professional supervision. The formula contains Zhi Shi (Aurantii Fructus Immaturus) and Gui Zhi (Cinnamomi Ramulus), which are traditionally used with caution in pregnancy due to their potential to move Qi and Blood and stimulate uterine contractions. Should only be used if the pattern clearly warrants it and under close monitoring by a qualified TCM practitioner.

Breastfeeding

No specific data on breast milk transfer exists for the herbs in this formula. Due to the lack of safety data, caution is advised during breastfeeding. Use only under the guidance of a qualified practitioner who can weigh potential benefits against unknown risks.

Children

For children, the adult dose is typically reduced to 1/3–1/4 based on body weight or age, with the total daily dose split into three warm administrations. A common pediatric dosage is Zhi Shi 6g, Hou Po 6g, Xie Bai 12g, Gui Zhi 1.5g, Gua Lou 6–8g. Monitor closely for gastrointestinal reactions such as diarrhea or abdominal pain. Not recommended for children under 2 years. If any adverse effects occur, discontinue immediately and consult a healthcare provider.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zhi Shi Xie Bai Gui Zhi Tang

No well-documented drug interactions with specific pharmaceuticals exist. However, the formula contains herbs with antiplatelet and vasodilatory effects (e.g., Xie Bai, Gua Lou, Gui Zhi). Caution is advised when used concurrently with anticoagulants (warfarin, heparin) or antiplatelet drugs (aspirin, clopidogrel) due to a theoretical increased bleeding risk. The formula may also potentiate antihypertensive medications. Consult a healthcare provider before combining with prescription drugs, and monitor for signs of bleeding or excessive blood pressure reduction.

Usage Guidance

Practical advice for getting the most out of Zhi Shi Xie Bai Gui Zhi Tang

Best time to take

Best taken 30 minutes after meals to minimize potential stomach irritation from the strong Qi-moving herbs.

Typical duration

Typically prescribed for 2–4 weeks for acute episodes; may be used for 4–8 weeks for chronic conditions, with periodic reassessment by a practitioner.

Dietary advice

Avoid cold, raw, and greasy foods; limit dairy, rich, and fatty foods that produce phlegm. Light, warm, easily digestible meals are recommended. A small amount of warm rice wine may be added during decoction to enhance the formula's warming and unblocking effect.

Zhi Shi Xie Bai Gui Zhi Tang originates from Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing Han dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zhi Shi Xie Bai Gui Zhi Tang and its clinical use

胸痹心中痞,留气结在胸,胸满,胁下逆抢心,枳实薤白桂枝汤主之;人参汤亦主之。

In chest impediment with a glomus sensation in the heart, retained Qi binding in the chest, chest fullness, and Qi surging upward from the hypochondrium to attack the heart, Zhi Shi Xie Bai Gui Zhi Tang governs; Ren Shen Tang also governs.

— Jīn Guì Yào Lüè (Essential Prescriptions of the Golden Coffer), Chapter on Chest Impediment, Heart Pain, and Shortness of Breath

Historical Context

How Zhi Shi Xie Bai Gui Zhi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zhi Shi Xie Bai Gui Zhi Tang first appears in Zhang Zhongjing's Jin Gui Yao Lue (Han dynasty, ~200 CE) as a treatment for chest impediment (胸痹) characterized by chest fullness, pain, and rebellious Qi from the hypochondrium. The original formula uses Zhi Shi, Hou Po, Xie Bai, Gui Zhi, and Gua Lou, with a unique decoction method: Zhi Shi and Hou Po are boiled first to extract their descending and dispersing actions before adding the remaining herbs.

During the Wei-Jin to Tang-Song periods, understanding of the formula focused on external wind and cold as causative factors. In the Jin-Yuan era, a shift toward internal causes emerged, emphasizing Qi stagnation and phlegm. By the Ming-Qing period, the formula was interpreted primarily through the lens of Qi rebellion and phlegm-turbidity obstructing the chest. Notable modifications include using Gui Xin instead of Gui Zhi in some Tang texts, adding Ban Xia to enhance phlegm-drying, and incorporating Huang Jiu (rice wine) to warm and unblock the upper burner. Modern practitioners often use Zhi Ke (the mature fruit) in place of Zhi Shi, following the view that Zhang Zhongjing's original 'Zhi Shi' was actually today's Zhi Ke. The formula is now listed in the first batch of Classical Famous Prescriptions by China's National Administration of Traditional Chinese Medicine and is widely applied in cardiovascular, respiratory, and digestive disorders.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Zhi Shi Xie Bai Gui Zhi Tang

1

Mechanism of Zhishi Xiebai Guizhi Decoction on myocardial infarction based on network pharmacology and experimental validation (2023)

Wang JR, Su SJ, Li L, Zhou K, Yu YL. Mechanism of Zhishi Xiebai Guizhi Decoction on myocardial infarction based on network pharmacology and experimental validation. Chinese Pharmacological Bulletin, 2023, 39(5): 953-960.

This study used network pharmacology and in vivo experiments to investigate the formula's effects on myocardial infarction. The formula's active compounds (quercetin, naringenin, β-sitosterol, luteolin) were found to target TNF-α, IL-1β, IL-6, VEGFA, and IL-10, modulating the TNF signaling pathway. In a mouse model, the formula significantly improved left ventricular function and reduced inflammatory cytokines in infarcted myocardium.

Link
2

Modern Pharmacological Effect of Zhishi Xiebai Guizhitang: A Review (2023)

He ZZ, Yang Z, Qi YJ, et al. Modern Pharmacological Effect of Zhishi Xiebai Guizhitang: A Review. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(6): 254-259.

A comprehensive review of pharmacological studies from the past decade. The formula and its individual herbs improve myocardial ischemia, ischemia-reperfusion injury, and hypoxia. Mechanisms include regulating TXB2/PGI2 balance, activating PI3K/Akt/eNOS pathway, modulating ATP-sensitive potassium channels, reducing oxidative stress (MDA, SOD), and inhibiting inflammation. Clinical applications focus on coronary heart disease, unstable angina, myocardial infarction, and sinus bradycardia.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.