Ze Xie Tang

Alisma Decoction · 泽泻汤

Also known as: Jin Gui Ze Xie Tang (金匮泽泻汤), Ze Xie San (泽泻散, Alisma Powder) — alternate form in Pu Ji Fang, Bai Zhu Tang (白术汤) — alternate name in Yi Chao Lei Bian

A remarkably simple two-herb classical formula from the Jin Gui Yao Lue, designed to relieve dizziness and vertigo caused by excess fluid accumulating in the body. Ze Xie (water plantain) drains the retained water downward, while Bai Zhu (atractylodes) strengthens the digestive system to prevent further fluid buildup. It is commonly used today for conditions like Meniere's disease, vertigo, high blood pressure with dizziness, and high cholesterol.

Origin Jin Gui Yao Lue (《金匮要略》, Synopsis of the Golden Chamber) by Zhang Zhongjing — Eastern Han dynasty (东汉), ~200 CE
Composition 2 herbs
Ze Xie
King
Ze Xie
Bai Zhu
Deputy
Bai Zhu
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ze Xie Tang is designed to correct these specific patterns.

Why Ze Xie Tang addresses this pattern

This is the primary pattern Ze Xie Tang was designed for. When water-Drink accumulates below the heart due to Spleen weakness, it obstructs the normal upward movement of clear Yang and causes turbid Yin to rise and cloud the head. The Jin Gui Yao Lue describes this precisely: "when there is propping Drink below the heart, the person suffers from dizzying cloudedness." Ze Xie powerfully drains this pathological water downward through the urinary pathway, while Bai Zhu strengthens the Spleen to restore its control over fluid metabolism. The formula directly addresses the core mechanism of Drink-induced vertigo by removing the excess fluid and restoring normal ascending-descending dynamics of Qi and water.

A practitioner would look for one or more of these signs

Dizziness

Heavy, foggy dizziness that worsens with position changes or after drinking fluids

Vertigo

Sensation of spinning or the environment moving

Nausea

Nausea accompanying the dizziness, sometimes with watery vomit

Chest Fullness

Sensation of stuffiness or fullness in the chest and upper abdomen

Reduced Urination

Decreased or scanty urination reflecting impaired water metabolism

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ze Xie Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Water-Dampness Flooding Upward

TCM Interpretation

TCM understands Meniere's disease as a manifestation of internal water-Drink or Phlegm-Dampness disturbing the head. The episodic vertigo, tinnitus, hearing loss, and fullness in the ear correspond closely to the classical description of "propping Drink below the heart causing dizzying cloudedness." The Spleen's failure to properly transform and transport fluids allows pathological water to accumulate and rise upward, disturbing the clear orifices (including the ears). The fluctuating nature of Meniere's attacks reflects the dynamic quality of water-Drink, which can surge upward when triggered by factors like fatigue, dietary excess, or weather changes that further burden the Spleen.

Why Ze Xie Tang Helps

Ze Xie Tang directly targets the fluid retention mechanism that TCM considers central to Meniere's disease. Ze Xie powerfully promotes urination and drains the accumulated water downward, reducing the upward pressure of turbid fluid on the head and ears. Bai Zhu strengthens the Spleen to prevent further fluid accumulation. Modern pharmacological research has demonstrated that Ze Xie Tang can reduce endolymphatic hydrops (inner ear fluid pressure), which closely parallels its traditional action of draining retained Drink. Clinical studies have reported effectiveness rates above 90% when the formula is used with modifications for Meniere's disease. In practice, the base formula is typically augmented with herbs like Tian Ma, Ban Xia, or Fu Ling for more severe or complex presentations.

Also commonly used for

Dizziness

Chronic or recurrent dizziness with a heavy, foggy quality

Hypertension

Hypertension with Phlegm-Dampness pattern, dizziness, and heaviness

Non-Alcoholic Fatty Liver Disease

Fatty liver linked to Dampness and Phlegm turbidity

Vertebrobasilar Insufficiency

Dizziness from poor blood flow to the brain stem, with Phlegm-Dampness pattern

Cervical Vertigo

Neck-related dizziness with Phlegm-turbidity obstruction pattern

Edema

Mild water retention and swelling from Spleen weakness

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ze Xie Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ze Xie Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ze Xie Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ze Xie Tang works at the root level.

Ze Xie Tang addresses a condition where the Spleen's ability to manage body fluids has weakened, allowing pathological fluid (called "retained Drink" or zhi yin 支饮 in TCM) to accumulate in the area below the heart, roughly corresponding to the upper abdomen and chest region.

In a healthy body, the Spleen transforms ingested fluids and distributes them throughout the body as nourishing moisture. When the Spleen becomes weak (from overwork, poor diet, constitutional tendency, or chronic illness), it can no longer properly move these fluids. Water begins to pool and stagnate internally, forming what TCM calls Drink (yin 饮), a relatively thin, clear type of pathological fluid. This Drink collects in the middle and upper body.

The key symptom this creates is dizziness and a foggy, heavy-headed sensation (mao xuan 冒眩). The mechanism is described as: when water accumulates below the heart, it blocks the normal upward flow of clear Yang Qi to the head while simultaneously causing turbid Yin to surge upward. The head, which should be nourished by clear, light Qi, instead receives turbid, heavy fluid. The result is a heavy, clouded sensation in the head with vertigo and dizziness. This is often described classically as "clear Yang cannot ascend, turbid Yin rises to cloud the head" (清阳不升, 浊阴上冒). Additional symptoms may include a feeling of fullness or stuffiness in the chest, nausea, cough, and reduced urination. The tongue coating is typically white and greasy, and the pulse is often slippery or wiry, reflecting the presence of internal Dampness and fluid stagnation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bland and sweet with a slight bitter note — bland to drain Dampness and promote urination, sweet to support the Spleen, and bitter to dry Dampness.

Channels Entered

Kidney Bladder Spleen Stomach

Ingredients

2 herbs

The herbs that make up Ze Xie Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Ze Xie

Ze Xie

Water plantain rhizome

Dosage 15 - 30g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Ze Xie Tang

The chief herb in this formula, Ze Xie (Alisma) is sweet, bland, and cold. It powerfully promotes urination and drains water-Dampness downward through the Bladder, directly removing the fluid accumulation (retained Drink) from below the heart that is causing dizziness. By draining the turbid Yin downward, it restores the normal ascent of clear Yang to the head.
Deputy — Assists and enhances the King
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 6 - 15g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Ze Xie Tang

Bai Zhu (white Atractylodes rhizome) is bitter, sweet, and warm. It strengthens the Spleen and dries Dampness, addressing the root cause of fluid accumulation by restoring the Spleen's ability to transform and transport water. While Ze Xie treats the branch (draining existing fluid), Bai Zhu treats the root (preventing new fluid buildup). Together the two herbs form a complementary pair that both eliminates and prevents pathological fluid retention.

Why This Combination Works

How the herbs in Ze Xie Tang complement each other

Overall strategy

The pathomechanism is Spleen weakness leading to water-Drink accumulation below the heart, with turbid Yin rising to cloud the head. The formula uses a simple but powerful two-herb strategy: drain the existing water downward (treat the branch) while strengthening the Spleen to prevent further fluid accumulation (treat the root).

King herbs

Ze Xie (Alisma, used at a heavy dose of 5 liang in the original text, roughly 2.5 times the dose of Bai Zhu) is the King herb. It is sweet, bland, and cold, entering the Kidney and Bladder channels. It powerfully promotes urination and leaches out Dampness, directing the stagnant water downward through the urinary system. By removing the pathological fluid that is blocking the normal ascent of clear Yang to the head, it directly relieves the dizziness and foggy-headedness. Its cold nature also helps clear any mild Heat that may arise from the fluid stagnation.

Deputy herbs

Bai Zhu (Atractylodes macrocephala, used at 2 liang) serves as the Deputy. It is warm, bitter, and sweet, entering the Spleen and Stomach channels. It strengthens the Spleen Qi and dries Dampness, restoring the Spleen's central role in fluid metabolism. Where Ze Xie works from below to drain water out, Bai Zhu works from the center to restore the Spleen's control over water. This complementary pairing addresses both the symptom and its underlying cause.

Notable synergies

The Ze Xie and Bai Zhu pairing is a classical drug couple (yao dui 药对) widely used across many formulas for managing water metabolism. Ze Xie drains downward while Bai Zhu consolidates from the center; one is cold and draining while the other is warm and tonifying. The 5:2 dosage ratio in this formula deliberately emphasizes the draining action over the tonifying, reflecting that this is primarily a formula for an acute excess condition (fluid accumulation) rather than a chronic deficiency formula. Together they accomplish what classical commentators describe as "draining water to treat the branch, strengthening the Spleen to treat the root" (泻水以治其标, 健脾以治其本).

How to Prepare

Traditional preparation instructions for Ze Xie Tang

Classical method (from the Jin Gui Yao Lue): Combine Ze Xie (泽泻) 5 liang and Bai Zhu (白术) 2 liang (modern equivalents: approximately 15g Ze Xie and 6g Bai Zhu) with approximately 400 ml (two sheng) of water. Bring to a boil, then simmer until the liquid is reduced to roughly 200 ml (one sheng). Strain out the dregs.

Dosing: Divide into two portions and take warm, twice daily. In modern clinical practice, some practitioners use larger modern-equivalent doses (e.g. 50g Ze Xie and 20g Bai Zhu for a single day's decoction) following the original 5:2 ratio, particularly for acute vertigo presentations. The decoction is simple and quick to prepare given that it contains only two herbs.

Common Modifications

How practitioners adapt Ze Xie Tang for specific situations

Added
Ban Xia

9 - 12g, dries Dampness and descends rebellious Stomach Qi to stop vomiting

Tian Ma

9 - 15g, calms internal Wind and stops dizziness

When dizziness is severe and accompanied by nausea or vomiting of thin watery fluid, Ban Xia dries the Phlegm-Dampness and harmonizes the Stomach, while Tian Ma specifically addresses the vertigo by calming internal Wind stirred up by Phlegm.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ze Xie Tang should not be used or requires extra caution

Avoid

Yin deficiency without Dampness or fluid retention. Ze Xie is a strongly draining, cold herb that can injure Yin and body fluids. If dizziness is caused by Yin deficiency or Blood deficiency rather than by fluid accumulation, this formula will worsen the condition.

Avoid

Kidney Qi deficiency with seminal emission (spermatorrhea) or urinary incontinence. The strong diuretic action of Ze Xie can further deplete Kidney Qi and worsen these conditions.

Caution

Cold constitution with deficiency of Spleen and Stomach Yang. Ze Xie is cold in nature and may further damage the middle burner Yang Qi in patients who already show signs of cold, such as cold limbs, loose stools from cold, and a pale tongue.

Caution

Prolonged or high-dose use. Ze Xie has been reported to have potential liver and kidney toxicity with long-term, large-dose administration. This formula should be used for a defined course and not taken indefinitely.

Caution

Dizziness caused by Liver Yang rising or Liver Fire. This formula addresses fluid-retention dizziness specifically. Dizziness from ascending Liver Yang or Liver Fire requires a different treatment strategy.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe at standard doses for short courses, but caution is advised. Ze Xie is a strongly draining, cold herb that promotes significant fluid movement. While it is not classically listed as a prohibited herb during pregnancy, its potent diuretic action could theoretically disturb fluid balance in a pregnant woman. Some classical sources note that Ze Xie root and seed were traditionally considered beneficial for easing labor and promoting fertility, suggesting it was not regarded as harmful. However, any use during pregnancy should be under the supervision of a qualified practitioner, and prolonged or high-dose use should be avoided.

Breastfeeding

No specific concerns have been documented for use during breastfeeding. Both Ze Xie and Bai Zhu are commonly used herbs that are not known to produce harmful effects through breast milk. However, Ze Xie's strong diuretic action could theoretically reduce overall fluid volume, which might affect milk production if used at high doses or for prolonged periods. Short-term use at standard doses under professional guidance is unlikely to pose significant risk. As always, a qualified practitioner should be consulted.

Children

Ze Xie Tang can be used in children, but dosage must be adjusted according to age and body weight. A common approach is to use one-third to one-half of the adult dose for children aged 6-12, and one-quarter for children under 6. The formula is relatively mild (only two herbs), which makes it more suitable for pediatric use than more complex formulas. Classical sources mention that Ze Xie-based formulas like Wu Ling San are effective and well-tolerated in young children for water-retention conditions. However, because Ze Xie is cold in nature and has strong draining properties, it should only be used for short courses in children and discontinued once symptoms resolve, to avoid injuring the developing digestive system.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ze Xie Tang

Diuretic medications: Ze Xie has well-documented diuretic effects and can increase sodium and potassium excretion. When combined with pharmaceutical diuretics (thiazides, loop diuretics, potassium-sparing diuretics), there is a risk of excessive fluid loss, electrolyte imbalance, or dehydration. Caution is warranted and electrolyte monitoring may be appropriate.

Antihypertensive medications: Both Ze Xie and Bai Zhu have demonstrated blood-pressure-lowering effects in clinical reports. Combined use with antihypertensive drugs could potentially cause excessive drops in blood pressure. Patients on blood pressure medication should have their readings monitored more closely.

Lipid-lowering drugs (statins, fibrates): Ze Xie Tang has demonstrated lipid-lowering effects through mechanisms including HMG-CoA reductase inhibition by alisol compounds. Combined use with statins could theoretically produce additive effects. While clinical evidence does not suggest significant adverse interactions, concurrent use should be supervised by a practitioner.

Usage Guidance

Practical advice for getting the most out of Ze Xie Tang

Best time to take

Warm, in two divided doses during the day, taken between meals (30-60 minutes before or after eating).

Typical duration

Acute vertigo or dizziness: 3-7 days; for chronic conditions like Ménière's disease or hyperlipidemia, may be extended to 2-4 weeks with practitioner reassessment.

Dietary advice

While taking this formula, avoid cold and raw foods, iced drinks, and excessive dairy products, as these can generate more Dampness and fluid retention in the body, counteracting the formula's draining effect. Greasy, oily, and heavy foods should also be reduced as they burden the Spleen's transforming function. Favor warm, lightly cooked meals that support the Spleen, such as congee (rice porridge), cooked grains, and mild soups. Small, frequent meals are preferable to large heavy ones. Reducing salt intake can also help manage fluid retention.

Ze Xie Tang originates from Jin Gui Yao Lue (《金匮要略》, Synopsis of the Golden Chamber) by Zhang Zhongjing Eastern Han dynasty (东汉), ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ze Xie Tang and its clinical use

Jin Gui Yao Lue (《金匮要略》), Chapter 12: Phlegm-Fluid Retention, Cough, and Dyspnea

「心下有支饮,其人苦冒眩,泽泻汤主之。泽泻汤方:泽泻五两,白术二两。上二味,以水二升,煮取一升,分温再服。」

"When there is propping fluid retention below the heart and the person suffers severely from dizziness and a heavy, clouded sensation in the head, Ze Xie Tang governs. Ze Xie Tang formula: Ze Xie five liang, Bai Zhu two liang. The above two ingredients are decocted in two sheng of water, reduced to one sheng, and taken warm in two divided doses."

Jin Gui Yao Lue Xin Dian (《金匮要略心典》) by You Zaijing

「冒者,昏冒而神不清,如有物冒蔽之也。」

"'Mao' [clouded sensation] means a dull, foggy feeling where the spirit is unclear, as though something is covering and obstructing the head."

Jin Gui Yao Lue Fang Yi (《金匮要略方义》)

「此方所治之冒眩,乃水饮停于中焦,浊阴上冒,清阳被遏所致。治当利湿化饮,健脾和中。」

"The dizziness and clouded sensation treated by this formula is caused by fluid-retention stagnating in the Middle Burner, turbid Yin surging upward, and clear Yang being suppressed. Treatment should promote the resolution of Dampness and transform retained fluid while strengthening the Spleen and harmonizing the Middle Burner."

Commentary by Gao Xushan (高学山)

「泽泻利水而决之于沟渠,白术培土而防之于堤岸。」

"Ze Xie drains the water and channels it away through the ditches, while Bai Zhu builds up the earth to hold it back like a levee."

Historical Context

How Ze Xie Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ze Xie Tang originates from Zhang Zhongjing's Jin Gui Yao Lue (Synopsis of the Golden Chamber), written during the Eastern Han dynasty around 200 CE. It appears in Chapter 12 on Phlegm-Fluid Retention (痰饮咳嗽病脉证并治), clause 24 (in standard numbering). The formula is remarkably minimalist, using only two herbs in a 5:2 ratio. This simplicity made it a subject of both admiration and scholarly debate throughout Chinese medical history. The Qing dynasty physician Lin Lifeng provided an influential commentary, likening the formula's mechanism to water management: Ze Xie channels floodwaters downward while Bai Zhu builds the earthen levee to prevent their return.

The formula also has alternate names in later texts: Ze Xie San (泽泻散, in Pu Ji Fang), Ze Xie Yin (泽泻饮, in Xing Yuan), and Bai Zhu Tang (白术汤, in Yi Chao Lei Bian). There was scholarly discussion about whether the condition described (支饮 with 冒眩) truly represents a subtype of narrow-sense phlegm-fluid retention (狭义痰饮) or a variant of propping fluid retention (支饮). The noted modern physician and Jin Gui Yao Lue scholar Wang Xuehua argued firmly that it belongs to narrow-sense phlegm-fluid retention, based on the location being "below the heart" (心下). In modern clinical practice, Ze Xie Tang has been widely adopted for treating Ménière's disease, cervical vertigo, and hyperlipidemia, significantly expanding its original classical scope.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Ze Xie Tang

1

Spectrum-Effect Analysis of Lipid-Lowering Components in Alismatis Rhizoma Decoction (In vitro + Molecular Docking Study, 2022)

Chang XY, Wu JS, Zhang FQ, Li ZZ, Jin WY, Wang JX, Wang WH, Shi Y. Evidence-Based Complementary and Alternative Medicine, 2022, Volume 2022, Article ID 2363242.

Researchers prepared nine versions of Ze Xie Tang with different herb ratios and tested them on a liver cell model of fat accumulation. They identified three triterpenoid compounds (alisol B 23-acetate, alisol C 23-acetate, and alisol B) as the key lipid-lowering active ingredients. Molecular docking showed these compounds could bind to the farnesoid X receptor (FXR), a known target for cholesterol regulation, suggesting a concrete molecular mechanism for the formula's traditional use.

2

Ze Xie Tang Targeting FKBP38/mTOR/SREBPs Pathway Improves Hyperlipidemia (Preclinical Study, 2022)

Xie Z, Li EW, Gao G, Du Y, Wang M, Wang H, Wang P, Qiao Y, Su Y, Xu J, Zhang X, Zhang Z. Journal of Ethnopharmacology, 2022.

This study investigated how Ze Xie Tang lowers blood lipids using a Western-diet-fed mouse model and liver cell experiments. The formula significantly reduced total cholesterol, triglycerides, and LDL cholesterol while raising HDL cholesterol, comparable to lovastatin. The mechanism was traced to the FKBP38/mTOR/SREBPs pathway, which governs lipid synthesis in the liver, providing molecular evidence for the formula's cholesterol-lowering effect.

Link
3

ZeXie Decoction in MSU-Induced Acute Gouty Arthritis via PI3K-AKT-mTOR Pathway (Preclinical Study, 2025)

Shi MF et al. Guangzhou University of Chinese Medicine, 2025.

This animal study examined Ze Xie Tang's effect on acute gouty arthritis caused by monosodium urate crystals. The formula showed anti-inflammatory activity, and the key compound alisol B was found to act through the PI3K-AKT-mTOR signaling pathway. This suggests a novel application of the formula beyond its traditional use for dizziness and fluid retention.

PubMed
4

Lipid-Lowering Effect of Alismatis Rhizoma Decoction in High-Fat Diet-Induced Hyperlipidemic Mice (Preclinical Study, 2014)

Song C, Huang X, Lu K, Peng M, Yu S, Fang N. Iranian Journal of Pharmaceutical Research, 2014, 13: 641-649.

This study tested Ze Xie Tang (in its classical 5:2 ratio) in mice fed a high-fat diet. The formula demonstrated significant lipid-lowering effects, reducing serum cholesterol and triglyceride levels. The findings supported the rationale of the classical combination compared to using either herb alone.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.