Formula Pill (Wan)

Xiao Jin Wan

Minor Golden Pill · 小金丸

Also known as: Xiao Jin Dan (小金丹, Minor Golden Elixir)

A classical formula from the Qing dynasty used to dissolve stubborn lumps, nodules, and masses caused by the combination of Cold, Phlegm, and stagnant Blood congealing in the body's tissues. It is commonly used for breast lumps, thyroid nodules, lymph node swelling, and similar conditions where firm, painfully hard masses develop under the skin without redness or heat. The formula works by warming the channels, breaking up Phlegm, and restoring Blood circulation to the affected area.

Origin Wai Ke Zheng Zhi Quan Sheng Ji (外科证治全生集, Complete Collection of Patterns and Treatments in External Medicine) by Wang Weidé (王维德) — Qīng dynasty, 1740 CE
Composition 10 herbs
She Xiang
King
She Xiang
Mu
Deputy
Mu Bie Zi (Momordicae Semen)
Zhi Cao Wu
Deputy
Zhi Cao Wu
Wu Ling Zhi
Assistant
Wu Ling Zhi
Ru Xiang
Assistant
Ru Xiang
Mo Yao
Assistant
Mo Yao
Dang Gui
Assistant
Dang Gui
Di Long
Assistant
Di Long
+2
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xiao Jin Wan is designed to correct these specific patterns.

Why Xiao Jin Wan addresses this pattern

When Cold and Phlegm combine in the channels and tissues, they can solidify into hard lumps or masses that grow slowly under the skin. The skin color above the mass remains unchanged, the mass feels hard and is painful, and the person may feel a deep, cold ache. Xiao Jin Wan directly warms the Cold (via Zhi Cao Wu), transforms the Phlegm (via Mu Bie Zi), and penetrates the congealed mass (via She Xiang) to break up this pattern from its core. The resin-based herbs (Ru Xiang, Mo Yao, Feng Xiang Zhi) prevent the Phlegm from re-forming by keeping Blood and Qi circulation active through the area.

A practitioner would look for one or more of these signs

Subcutaneous Nodules

Firm masses under the skin, often movable when pushed

Breast Lumps

Hard lumps in the breast with no skin color change

Scrofula

Neck swellings like chains of nodules

Joint Swelling

Bone or joint enlargement with firm, cold swelling

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xiao Jin Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Stasis and Phlegm Accumulation Cold-Phlegm Stagnation

TCM Interpretation

In TCM, breast lumps (called "Ru Pi" or "Ru Yan" depending on severity) are understood as the result of Liver Qi stagnation leading to disrupted fluid metabolism in the chest area. When Qi stops flowing smoothly, body fluids accumulate and thicken into Phlegm. Over time, this Phlegm binds with stagnant Blood, forming palpable hard or rubbery masses. Emotional stress, anger, and frustration commonly trigger this chain of events by constraining the Liver's spreading function. The breast area is traversed by the Liver and Stomach channels, making it particularly vulnerable to Qi stagnation and Phlegm accumulation.

Why Xiao Jin Wan Helps

Xiao Jin Wan attacks breast lumps at multiple levels. She Xiang penetrates deep into the breast tissue to break open congealed masses. Mu Bie Zi and Zhi Cao Wu dissolve the Phlegm-Cold component that forms the bulk of the nodule. Ru Xiang and Mo Yao restore Blood circulation through the affected area, while Dang Gui nourishes Blood to prevent the vigorous stasis-breaking action from depleting healthy tissue. Research including a meta-analysis of 858 cases has shown that Xiao Jin Wan combined with conventional treatment significantly improves outcomes in mammary gland hyperplasia compared to conventional treatment alone.

Also commonly used for

Lipoma

Subcutaneous lipomas and fatty lumps

Breast Cancer

Adjunctive use in early-stage breast masses

Chronic Pelvic Inflammatory Disease

Pelvic masses from chronic inflammation

Bone Tuberculosis

Cold abscesses from bone or joint TB

Uterine Fibroids

Uterine fibroids with Blood stasis and Phlegm

Keloid Scars

Hypertrophic or keloid scarring

Prostatitis

Chronic prostatitis with inflammation and swelling

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xiao Jin Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xiao Jin Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xiao Jin Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xiao Jin Wan works at the root level.

This formula addresses conditions where Cold, Dampness, and Phlegm have become trapped in the body's channels and tissues, gradually congealing with stagnant Blood to form palpable lumps, masses, or nodules. The underlying disease process typically begins when the body's Yang Qi is insufficient to warm and move fluids properly, or when emotional stress and Liver Qi stagnation disrupt the smooth flow of Qi and Blood.

When Qi stops moving freely, body fluids stagnate and thicken into Phlegm. Cold causes contraction and congealing, so when Cold-Dampness and Phlegm combine with stagnant Blood, they solidify into hard, immovable or slowly growing lumps under the skin. These lumps characteristically do not change the skin color above them (unlike hot, inflamed swellings), and they tend to be firm and painful with a cold quality. This is what TCM calls "Yin-type" sores or masses, in contrast to the red, hot, swollen "Yang-type" lesions. The affected areas may include the neck (scrofula), the breast (breast lumps), the thyroid area, the joints, or deep tissue anywhere in the body.

Because the root cause involves multiple pathogenic factors intertwined (Cold, Dampness, Phlegm, and Blood stasis all binding together), effective treatment must address all of them simultaneously: warming to dispel Cold, drying to eliminate Dampness, transforming Phlegm to break up the congealed substance, and invigorating Blood to restore circulation through the affected tissue.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly pungent and bitter with aromatic qualities — pungent to move Qi and Blood and open channels, bitter to dry dampness and dissolve masses, aromatic to penetrate obstructions.

Channels Entered

Ingredients

10 herbs

The herbs that make up Xiao Jin Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
She Xiang

She Xiang

Musk

Dosage 0.3 - 1g (in pill form)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Liver, Spleen

Role in Xiao Jin Wan

Powerfully aromatic and penetrating, She Xiang opens channels, invigorates Blood, disperses stagnation, and breaks through congealed masses. Its ability to penetrate everywhere in the body drives the entire formula's action deep into stagnant tissue.
Deputies — Assists and enhances the King
Mu

Mu Bie Zi (Momordicae Semen)

Dosage 1.5 - 3g (in pill form)
Preparation Shells and oil removed (去壳去油)

Role in Xiao Jin Wan

Disperses Phlegm toxin, reduces swelling, and dissipates nodules. Its strong ability to scatter hardened masses makes it a key herb for addressing the Phlegm-stagnation that forms palpable lumps under the skin.
Zhi Cao Wu

Zhi Cao Wu

Processed Wild Aconite Root

Dosage 1.5 - 3g (in pill form)
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Kidneys, Spleen
Preparation Must be processed (制) to reduce toxicity

Role in Xiao Jin Wan

Warms the channels, dispels Cold-Dampness, and relieves pain. Combined with Mu Bie Zi, it powerfully resolves cold, congealed, hardened masses characteristic of Yin-type sores and nodules.
Assistants — Supports or moderates other herbs
Wu Ling Zhi

Wu Ling Zhi

Flying squirrel feces

Dosage 1.5 - 3g (in pill form)
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Liver, Spleen
Preparation Stir-fried with vinegar (醋炒)

Role in Xiao Jin Wan

Invigorates Blood and relieves pain. Its warming nature and Blood-moving action support the formula's overall strategy of breaking through stasis and stagnation in the channels.
Ru Xiang

Ru Xiang

Frankincense resin

Dosage 0.75 - 1.5g (in pill form)
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Preparation Processed (制)

Role in Xiao Jin Wan

Moves Qi and invigorates Blood, reduces swelling and generates new tissue. Works together with Mo Yao to activate Blood circulation and relieve pain in areas of stagnation.
Mo Yao

Mo Yao

Myrrh resin

Dosage 0.75 - 1.5g (in pill form)
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Spleen
Preparation Processed (制)

Role in Xiao Jin Wan

Invigorates Blood, dispels stasis, reduces swelling, and promotes healing. Partners with Ru Xiang to form a classic Blood-moving pair that enhances the formula's ability to resolve masses.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 0.75 - 1.5g (in pill form)
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Preparation Stir-fried with wine (酒炒)

Role in Xiao Jin Wan

Nourishes and invigorates Blood, ensuring that the vigorous Blood-breaking action of the other herbs does not damage healthy Blood. Prevents the formula from being overly drastic.
Di Long

Di Long

Earthworm

Dosage 1.5 - 3g (in pill form)
Temperature Cold
Taste Salty (咸 xián)
Organ Affinity Liver, Spleen, Urinary Bladder, Lungs

Role in Xiao Jin Wan

Clears heat and opens the channels and collaterals. Its strong channel-penetrating action helps the other herbs reach deep tissue where stagnation has congealed into masses.
Fe

Feng Xiang Zhi (Liquidambaris Resina)

Dosage 1.5 - 3g (in pill form)

Role in Xiao Jin Wan

Invigorates Blood, relieves pain, resolves toxins, and promotes tissue healing. Supports the resin-based group (with Ru Xiang and Mo Yao) in dispersing stagnation and reducing swelling.
Envoy — Directs the formula to its target
Xi

Xiang Mo

Prepared Ink

Dosage 0.12 - 0.5g (in pill form)
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Astringent (涩 sè)
Organ Affinity Lungs, Liver

Role in Xiao Jin Wan

Enters the Blood level and helps stop bleeding, reduce swelling, and transform Phlegm. Its dark nature directs the formula into the Blood aspect, guiding the other herbs to where stasis has accumulated.

Why This Combination Works

How the herbs in Xiao Jin Wan complement each other

Overall strategy

The formula confronts a complex pathomechanism of Cold-Phlegm and Blood stasis congealing into masses by combining channel-warming, Phlegm-transforming, and Blood-invigorating herbs with a powerful aromatic penetrator that drives the formula deep into stagnant tissue.

King herbs

She Xiang (Musk) serves as the King because of its uniquely powerful aromatic, penetrating quality. It can reach everywhere in the body, breaking open blockages and driving stagnant Qi and Blood to move. No other herb matches its ability to force open congealed, hardened masses from the inside out. It also relieves pain and reduces swelling, making it the ideal lead herb for this formula's mission.

Deputy herbs

Mu Bie Zi (Momordica Seeds) and Zhi Cao Wu (Prepared Cao Wu) form the Deputy pair. Mu Bie Zi specializes in dispersing Phlegm toxin and breaking up hardened nodules, directly targeting the Phlegm component of the pathomechanism. Zhi Cao Wu is fiercely warming and pain-relieving, targeting the Cold-Dampness component. Together, they powerfully dissolve the cold, congealed, Phlegm-bound masses that define this formula's scope.

Assistant herbs

A large group of Assistants addresses the Blood stasis and channel obstruction components. Wu Ling Zhi, Ru Xiang, Mo Yao, and Feng Xiang Zhi all invigorate Blood, dispel stasis, and relieve pain from different angles (reinforcing Assistants). Di Long is a strong channel-opener that helps the formula penetrate deep into obstructed collaterals, ensuring the active ingredients reach the site of disease. Dang Gui serves as a restraining Assistant: by nourishing Blood, it prevents the formula's many Blood-moving herbs from causing excessive depletion of healthy Blood.

Envoy herbs

Xiang Mo (Prepared Ink) enters the Blood level and directs the formula's action into the deepest layer of Blood stasis. Its dark, astringent nature also helps control any bleeding that might occur from the vigorous Blood-moving action of the other herbs.

Notable synergies

The Mu Bie Zi and Zhi Cao Wu pairing is a recognized combination for resolving toxic swelling and deep cold masses. The Ru Xiang and Mo Yao pair is one of the most classic in Chinese medicine for moving Qi and Blood simultaneously and promoting tissue healing. She Xiang acts as the catalyst that amplifies every other herb's ability to penetrate blocked tissue.

How to Prepare

Traditional preparation instructions for Xiao Jin Wan

Xiao Jin Wan is a prepared pill (成药) and is not typically made as a raw-herb decoction at home. It is taken as a commercially manufactured patent medicine in pill form (traditionally a paste pill, 糊丸).

Traditional preparation (historical): The pills were originally to be crushed, soaked in Chinese grain liquor (白酒, baijiu) for 2–4 hours, then taken orally with the liquor. Modern pharmacological research confirms that the liquor extraction enhances the dissolution of the formula's lipid-soluble active compounds (such as musk ketone, boswellic acids, and volatile oils), which are poorly soluble in water alone.

Modern preparation (current standard): The pills are very hard (paste pills with extreme density) and must be crushed or broken up before swallowing with warm water. If swallowed whole, the pills may not fully disintegrate in the stomach, reducing effectiveness and increasing the risk of adverse reactions. Some modern manufacturers produce micro-pill versions that can be swallowed directly without crushing. Standard dosage: 1.2–3 grams per dose, taken twice daily.

Common Modifications

How practitioners adapt Xiao Jin Wan for specific situations

Added
Chai Hu

6 - 9g, to spread Liver Qi

Xiang Fu

9 - 12g, to move Qi and relieve chest distention

When emotional constraint is a prominent factor driving the stagnation, adding Qi-moving herbs to address the root Liver Qi stagnation enhances the formula's ability to prevent recurrence of masses.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xiao Jin Wan should not be used or requires extra caution

Avoid

Pregnancy: This formula is strictly prohibited during pregnancy. It contains Musk (She Xiang), which can stimulate uterine contractions and cause miscarriage, as well as Prepared Cao Wu (Zhi Cao Wu), which is toxic and may harm the fetus, and other strong Blood-moving herbs.

Avoid

Breastfeeding: Officially prohibited for breastfeeding women due to the presence of toxic and potent Blood-moving ingredients that may transfer through breast milk.

Avoid

Infants and young children (under 3 years): Prohibited due to the formula's content of Prepared Cao Wu (Zhi Cao Wu / aconitum) and other potent ingredients with narrow safety margins.

Avoid

Known allergy to any component: Allergic skin reactions have been reported. Anyone with a known allergy to musk, frankincense, myrrh, or other ingredients should not take this formula.

Avoid

Active hot-type sores and abscesses (yang-pattern lesions with redness, heat, and swelling): This formula is designed for cold, yin-type masses. Using it for hot, inflammatory conditions with obvious redness and heat would be inappropriate and potentially harmful.

Caution

Weak digestion or sensitive stomach: The formula contains frankincense (Ru Xiang) and myrrh (Mo Yao), which commonly irritate the stomach. People with weak digestion should use with caution and under professional guidance.

Caution

Liver or kidney impairment: The aconitum alkaloids from Prepared Cao Wu are processed by the liver and kidneys. Those with compromised liver or kidney function should use with extra caution.

Caution

Do not use long-term or in excessive doses: The formula contains Prepared Cao Wu (Zhi Cao Wu), which contains aconitum alkaloids. Prolonged or excessive use increases the risk of cumulative toxicity.

Caution

Do not take concurrently with ginseng-containing preparations: Wu Ling Zhi (Flying Squirrel Feces) in the formula is classically contraindicated with Ren Shen (Ginseng), as described in the traditional "eighteen incompatibilities" (shi ba fan).

Caution

Athletes subject to doping tests should use with caution, as the musk content may trigger a positive result.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated — absolutely prohibited during pregnancy. This formula contains She Xiang (Musk), which has well-documented uterine-stimulating properties and has been used historically as an abortifacient. It also contains Zhi Cao Wu (Prepared Aconite Lateral Root), which is toxic and poses a risk to fetal development. Additionally, multiple other ingredients (Ru Xiang, Mo Yao, Wu Ling Zhi, Dang Gui) are strong Blood-moving substances that can increase the risk of miscarriage. The official Chinese pharmaceutical labelling classifies this formula as "Pregnant women prohibited" (孕妇禁用).

Breastfeeding

Contraindicated during breastfeeding. The official Chinese drug labelling for Xiao Jin Wan states "breastfeeding women prohibited" (哺乳期妇女禁用). The formula contains Musk (She Xiang), whose active compound muscone is lipophilic and may transfer into breast milk. It also contains Prepared Cao Wu (Zhi Cao Wu), which contains aconitum alkaloids with known toxicity that could be harmful to a nursing infant. The Blood-moving and mass-dissolving herbs may also theoretically affect lactation. Do not use while breastfeeding.

Children

Officially prohibited for infants and toddlers (婴幼儿禁用). For older children, the official labelling states "children's dosage should be reduced" (小儿酌减), but no specific pediatric dosing guidelines are provided. Due to the presence of Zhi Cao Wu (Prepared Aconite), which contains aconitum alkaloids with a narrow therapeutic window, and She Xiang (Musk), which is a potent aromatic that opens orifices, this formula requires extra caution in pediatric use. Any use in children must be under strict medical supervision with significantly reduced doses. Generally not recommended for children under 6 years of age.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xiao Jin Wan

Wu Ling Zhi (Flying Squirrel Feces) and Ginseng: This formula contains Wu Ling Zhi, which is traditionally listed as incompatible with Ren Shen (Ginseng) under the classical "eighteen incompatibilities" (十八反). Concurrent use with ginseng-containing medicines or supplements should be avoided.

Zhi Cao Wu (Prepared Aconite) and cardiac medications: Zhi Cao Wu contains aconitum alkaloids that affect cardiac ion channels. Concurrent use with antiarrhythmic drugs (e.g. amiodarone, digoxin), beta-blockers, or calcium channel blockers may increase the risk of cardiac arrhythmia or toxicity. Use with cardiac glycosides is of particular concern.

Blood-thinning medications: The formula contains multiple Blood-moving ingredients (Ru Xiang, Mo Yao, Wu Ling Zhi, Dang Gui, She Xiang, Di Long) that may enhance anticoagulant or antiplatelet effects. Caution is advised when used alongside warfarin, heparin, aspirin, clopidogrel, or other anticoagulants/antiplatelets, as the risk of bleeding may increase.

Sedative and CNS-depressant medications: The formula has documented sedative and analgesic properties. Combining it with benzodiazepines, opioids, or other CNS depressants may potentiate sedation.

Usage Guidance

Practical advice for getting the most out of Xiao Jin Wan

Best time to take

Twice daily, ideally 30 minutes after meals to reduce the risk of stomach irritation from frankincense and myrrh.

Typical duration

Typically taken in courses of 4–8 weeks, then reassessed by a practitioner. Should not be used long-term without supervision due to the presence of Prepared Aconite.

Dietary advice

Avoid spicy, greasy, and fried foods while taking this formula, as they can generate internal Heat and Dampness that interfere with its actions. Avoid seafood and shellfish, which are considered "hair-generating" (发物) foods in TCM that may trigger or worsen skin reactions and allergic responses. Avoid cold and raw foods (such as ice water, raw salads, and chilled fruits), as the formula is designed to warm and dissolve cold-phlegm masses, and cold foods counteract this warming mechanism. Avoid alcohol in excess, though traditionally the pills were taken with a small amount of grain liquor (baijiu) to enhance absorption of lipid-soluble components. Light, easily digestible, warm-cooked meals are recommended to support the Spleen and Stomach during treatment.

Xiao Jin Wan originates from Wai Ke Zheng Zhi Quan Sheng Ji (外科证治全生集, Complete Collection of Patterns and Treatments in External Medicine) by Wang Weidé (王维德) Qīng dynasty, 1740 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xiao Jin Wan and its clinical use

Xiao Jin Dan (小金丹) was first recorded in the Wai Ke Zheng Zhi Quan Sheng Ji (外科证治全生集, Complete Collection of Patterns and Treatments in External Medicine) by Wang Weidé (王维德, courtesy name Hongxu 洪绪), published in 1740 during the Qing dynasty. The text is primarily a surgical (external medicine) treatise that established the principle of distinguishing yin-type and yang-type lesions.

Wang Weidé described the formula's core indication as treating yin-type deep sores and masses (阴疽) where the skin colour remains unchanged, the mass is hard and painful, and there is no redness or heat. The underlying pathology is cold-phlegm and Blood stasis congealing in the channels and collaterals. The original text states the formula's function as: "散结消肿,化瘀止痛" (disperse masses and reduce swelling, transform Blood stasis and stop pain).

In the same text, Wang also stated his overarching treatment philosophy: "以消为贵,以托为畏" ("to dissolve [masses internally] is prized; to push them outward is to be avoided"). This principle underscores why Xiao Jin Dan was designed as an internal-dissolution formula rather than a surgical approach.

Historical Context

How Xiao Jin Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xiao Jin Dan (小金丹, "Little Golden Pill") was created by Wang Weidé (王维德, 1669–1749), a renowned Qing dynasty external medicine specialist from Wuxian (Suzhou), Jiangsu province. Wang came from a family of surgeons (his great-grandfather Wang Ruogu was already famous in the field), and he spent over 40 years in clinical practice before compiling the Wai Ke Zheng Zhi Quan Sheng Ji at age 72 in 1740. Wang was the founding figure of the "Quan Sheng Pai" (全生派, "Preserve Life School"), one of the three major schools of external medicine during the Ming-Qing period.

The Quan Sheng School's hallmark was its emphasis on treating yin-type deep sores (阴疽) with warm, internally dissolving methods rather than surgery. Wang rejected the use of knives, needles, and caustic medicinals, stating his goal was "to dissolve, not to push outward." Xiao Jin Dan, along with his other famous formulas Yang He Tang (阳和汤) and Xi Huang Wan (犀黄丸), became the clinical cornerstones of this approach. The book was so influential that it was described as being "kept at the bedside by virtually every later generation of external medicine doctors."

In modern times, Xiao Jin Dan was adapted into three standard dosage forms: Xiao Jin Wan (pills), Xiao Jin Pian (tablets), and Xiao Jin Jiao Nang (capsules). Because natural musk has become extremely scarce and expensive (costing several times the price of gold), all modern commercial preparations use artificial musk (人工麝香) as a substitute. The formula remains one of the most widely prescribed Chinese patent medicines for breast lumps, thyroid nodules, and lymph node tuberculosis in China today.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Xiao Jin Wan

1

Screening for anti-inflammation quality markers of Xiaojin Pills (Laboratory study with pharmacological analysis, 2018)

Xiong X, He YN, Feng B, Pan Y, Zhang HZ, Ke XM, Zhang Y, Yang M, Han L, Zhang DK. Scientific Reports, 2018, 8(1): 7454.

This study quantified 13 chemical compounds in Xiaojin Pills and measured their COX-2 inhibition rates. Using spectrum-effect relationship analysis and protein interaction networks, three anti-inflammatory quality markers were identified: protocatechuic acid, beta-boswellic acid, and levistilide A. The study confirmed Xiaojin Pills' anti-inflammatory mechanism and also referenced a meta-analysis of 858 cases showing that Xiaojin Pills combined with conventional therapy significantly improved cure rates for mammary gland hyperplasia compared to Western medicine alone.

2

Pharmacodynamic comparison of Xiaojin Pills taken with baijiu versus water (Preclinical pharmacological study, 2021)

Song J, Liao W, Deng X, Zhang DK, Lin JZ, Xu RC, Han L. Journal of Ethnopharmacology, 2022, 282: 114628.

This study compared the efficacy of Xiaojin Pills when taken with traditional Chinese grain liquor (baijiu) versus plain water, using animal models. Results showed that the liquor-administered form was significantly superior in anti-platelet aggregation, anti-inflammation, pain relief, and anti-mammary gland hyperplasia effects, especially at lower doses. Metabolomics revealed different mechanisms, with the liquor extract having additional regulatory effects on linoleic acid metabolism.

PubMed
3

Pharmacodynamic difference in anti-breast cancer activity between water and liquor extracts of Xiaojin Pills (Preclinical study, 2022)

Song J, Liao W, Deng X, Zhang DK, Lin JZ, Xu RC, Han L. Journal of Ethnopharmacology, 2022, 293: 115282.

Using MCF-7 breast cancer cell lines and a xenograft mouse model, this study demonstrated that both water and liquor extracts of Xiaojin Pills reduced tumor volume, but the liquor extract showed significantly stronger effects. Molecular analysis showed both extracts modulated the PI3K/AKT signaling pathway by upregulating PTEN and BAX while downregulating BCL-2, p-PI3K, and p-AKT, with the liquor extract producing more pronounced changes.

PubMed
4

Serum pharmacochemistry and pharmacokinetics of Xiaojin Pills with baijiu versus water (Preclinical study, 2023)

Song J, Liao W, Deng X, Zhang DK, Lin JZ, Xu RC, Han L. Journal of Ethnopharmacology, 2023, 300: 115723.

This study investigated the material basis for the efficacy difference between the two administration methods by analyzing serum pharmacochemistry and pharmacokinetics in rats. Results showed that the liquor-based administration released significantly more lipid-soluble active compounds into the bloodstream, providing a scientific rationale for the traditional practice of taking the pills with liquor.

5

Systematic review and comment on modern study of Xiaojin Pills (Review article, 2018)

Xiong X, Feng B, Cao B, Zhang DK, Xiong KP, Lin JZ, Ci ZM, Xu RC, Han L. Zhongguo Zhong Yao Za Zhi, 2018, 43(24): 4801-4807.

A comprehensive review summarizing the historical evolution, material basis, pharmacological actions, and quality control of Xiaojin Pills. The paper systematically discussed the formula's anti-inflammatory, Blood-activating, anti-tumor, and mass-dissolving properties, and identified areas requiring further research for the formula's modernization.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.