Formula Pill (Wan)

Suo Quan Wan

Shut the Sluice Pill · 縮泉丸

Also known as: Gù Zhēn Dān (固真丹, Secure the True Pellet), Restrict the Fountain Pill

A classical three-herb formula used to warm the Kidneys and help the Bladder hold urine properly. It is commonly used for frequent urination, bedwetting in children, and nighttime urination caused by coldness and weakness in the lower body.

Origin Jiào Zhù Fù Rén Liáng Fāng (校注妇人良方, Revised Fine Formulas for Women) — Sòng dynasty, ~1237 CE (original text by Chén Zìmíng; annotated by Xuē Jǐ in the Míng dynasty)
Composition 3 herbs
Yi Zhi Ren
King
Yi Zhi Ren
Wu Yao
Deputy
Wu Yao
Shan Yao
Assistant
Shan Yao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Suo Quan Wan is designed to correct these specific patterns.

Why Suo Quan Wan addresses this pattern

When Kidney Yang is insufficient, it cannot warm and support the Bladder's function of storing urine. The Bladder, which is the exterior partner of the Kidney, relies on Kidney Yang for its Qi transformation and holding capacity. Without adequate warmth, the lower body becomes cold and the Bladder loses its ability to restrain urine, leading to frequent, clear urination or involuntary leakage. Suo Quan Wan directly targets this mechanism: Yi Zhi Ren warms Kidney Yang and astringes, Wu Yao disperses the accumulated cold and restores Qi movement, and Shan Yao nourishes the Kidney foundation. The formula is particularly well suited to milder Kidney Yang deficiency focused on urinary symptoms, rather than severe Yang collapse with generalized coldness.

A practitioner would look for one or more of these signs

Frequent Urination

Frequent, clear, copious urination, especially at night

Enuresis

Bedwetting or involuntary urination during sleep

Urinary Incontinence

Inability to hold urine, dribbling after urination

Cold Limbs

Cold extremities, especially cold lower body

Lower Back Pain

Soreness and weakness of the lower back and knees

Eye Fatigue

Fatigue and low spirits, pale complexion

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Suo Quan Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, bedwetting (enuresis) is most commonly understood as a failure of the Kidney's 'gating' function. The Kidney governs the opening and closing of the lower body's waterways. In children, Kidney Qi is not yet fully developed, and if cold further weakens it, the Bladder cannot hold urine during sleep when conscious control is relaxed. The key signs pointing to this pattern are: pale urine, cold lower abdomen, a pale tongue with white coating, and a deep, weak pulse. If the child also shows signs of restless sleep, anxiety, or heart palpitations, a more complex Heart-Kidney pattern may be involved, requiring a different formula approach.

Why Suo Quan Wan Helps

Suo Quan Wan is one of the most commonly used base formulas for childhood enuresis from Kidney deficiency cold. Yi Zhi Ren directly warms the Kidney and has a classical reputation for reducing urinary leakage. Wu Yao clears cold from the Bladder and lower abdomen, restoring the Bladder's ability to hold urine overnight. Shan Yao gently supports the Spleen and Kidney, helping to consolidate the body's fluid-holding capacity. The formula is mild and well tolerated by children. Clinical studies have reported high efficacy rates when Suo Quan Wan is used as a base with additions like Sang Piao Xiao and Long Gu for more severe cases.

Also commonly used for

Frequent Urination

Especially with clear, copious urine due to cold

Nocturia

Frequent nighttime urination in the elderly

Diabetes Insipidus

Diabetes insipidus with excessive dilute urination

Chronic Glomerulonephritis

Proteinuria associated with Kidney deficiency

Excessive Salivation

Drooling from Spleen-Kidney Qi deficiency, when combined with other formulas

What This Formula Does

Every TCM formula has a specific set of actions — here's what Suo Quan Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Suo Quan Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Suo Quan Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Suo Quan Wan works at the root level.

The Kidneys in TCM govern water metabolism and control the opening and closing of the lower orifices. The Bladder, as the Kidney's paired organ, stores and excretes urine, but only when the Kidney's Qi transformation function (气化 qì huà) gives it the 'signal' to hold or release. When Kidney Yang becomes deficient and Cold settles in the lower body, this Qi transformation breaks down. The Bladder loses its ability to properly restrain urine, much like a gate whose latch has frozen and can no longer hold shut.

Without sufficient Kidney Yang warmth, fluids pass through the Bladder unchecked, leading to frequent, clear, copious urination during the day and involuntary bed-wetting at night. The body may also show other signs of Yang deficiency and internal Cold: cold limbs, fatigue, a pale tongue with white coating, and a deep, weak pulse. In children, the Kidneys are constitutionally immature, making them especially prone to this pattern, which is why classical texts note this formula is "especially effective for children."

The Spleen also plays a supporting role: it governs the transport and transformation of fluids. When both the Spleen and Kidney are weak, the body's overall capacity to manage water metabolism deteriorates, compounding the problem of uncontrolled urination.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly pungent (acrid) and sweet — pungent to warm and move Qi, dispel Cold, and restore Bladder Qi transformation; sweet to tonify the Spleen and Kidneys and consolidate essence.

Channels Entered

Kidney Bladder Spleen

Ingredients

3 herbs

The herbs that make up Suo Quan Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Yi Zhi Ren

Yi Zhi Ren

Sharp-leaf galangal fruits

Dosage 9 - 12g
Temperature Warm
Taste Pungent
Organ Affinity Kidneys, Spleen
Preparation Salt-fried (盐炒) to enhance its entry into the Kidney channel

Role in Suo Quan Wan

Warms the Kidneys and Spleen, consolidates Qi, astringes Essence, and directly reduces urinary frequency. As the principal herb, it addresses the core deficiency of Kidney Yang and restores the lower body's ability to contain fluids.
Deputy — Assists and enhances the King
Wu Yao

Wu Yao

Lindera roots

Dosage 6 - 12g
Temperature Warm
Taste Pungent
Organ Affinity Urinary Bladder, Kidneys, Lungs, Spleen

Role in Suo Quan Wan

Moves Qi and disperses cold from the Kidney and Bladder. By warming and promoting Qi transformation in the lower abdomen, it eliminates the cold pathogenic factor that prevents the Bladder from properly holding urine.
Assistant — Supports or moderates other herbs
Shan Yao

Shan Yao

Yam

Dosage 9 - 15g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen
Preparation In the original pill form, cooked with wine to form a paste used as the pill binder

Role in Suo Quan Wan

Tonifies the Spleen and Kidneys, binds Essence, and stabilizes the lower body. Its mild, nourishing nature complements the warming action of the other two herbs while providing an astringent quality that helps secure fluids. Also serves as the binding agent (excipient) in the pill form.

Why This Combination Works

How the herbs in Suo Quan Wan complement each other

Overall strategy

The formula addresses Kidney and Bladder deficiency cold, where weakness of Kidney Yang leads to the Bladder losing its ability to store and control urine. The strategy combines gentle Kidney warming with Qi movement and mild astringency, using just three herbs in a compact, efficient design.

King herbs

Yi Zhi Ren (Sharp-leaf Galangal Fruit) is the chief herb. Warm and acrid, it enters the Kidney and Spleen channels, where it warms Kidney Yang, consolidates the lower body's vital Qi, and directly astringes urination. Its dual action of warming and binding makes it uniquely suited to the pattern of cold-induced urinary loss.

Deputy herbs

Wu Yao (Lindera Root) serves as the deputy. While Yi Zhi Ren warms and consolidates, Wu Yao moves Qi and scatters cold. It specifically targets cold stagnation in the Kidney and Bladder area, restoring proper Qi transformation so the Bladder can resume its role of holding and releasing urine at the appropriate time. Together with Yi Zhi Ren, the pair warms the lower body from two complementary angles: one strengthens, the other unblocks.

Assistant herbs

Shan Yao (Chinese Yam) is a reinforcing assistant. Neutral in temperature and sweet in taste, it tonifies the Spleen and Kidney without being overly warming or drying. Its gentle astringent quality helps secure Essence and stabilize the lower body. It also balances the formula by providing nourishment, preventing the warming herbs from depleting Yin over time.

Notable synergies

Yi Zhi Ren and Wu Yao form the core therapeutic pair: Yi Zhi Ren warms and secures from the inside while Wu Yao disperses cold and moves Qi from the outside. Neither alone is sufficient. The addition of Shan Yao grounds the formula, ensuring that the warming and Qi-moving actions have a stable foundation of Spleen and Kidney support. The result is a formula that is warm but not harsh, astringent but not stagnating.

How to Prepare

Traditional preparation instructions for Suo Quan Wan

Grind Wu Yao and Yi Zhi Ren into fine powder in equal parts. Separately, cook Shan Yao powder with wine to form a paste. Use the Shan Yao paste as a binder to form the powdered herbs into small pills the size of Chinese parasol tree seeds (roughly 5-6mm). Take approximately 70 pills (about 9g) per dose, swallowed with lightly salted wine, plain wine, or rice water, before meals.

Modern usage: take 3 to 6g of prepared pills three times daily with warm water before meals. The formula can also be prepared as a decoction using standard dosages of each herb.

Common Modifications

How practitioners adapt Suo Quan Wan for specific situations

Added
Sang Piao Shao

9-12g, strongly secures Kidney Essence and stops enuresis

Long Gu

15-20g, calms the spirit and astringes to prevent leakage during sleep

Sang Piao Xiao is one of the strongest herbs for securing the Bladder gate and stopping enuresis. Long Gu adds astringent and spirit-calming properties, which helps when the child sleeps too deeply to sense bladder fullness.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Suo Quan Wan should not be used or requires extra caution

Avoid

Frequent urination or urinary difficulty due to Damp-Heat in the Bladder (presenting with dark, scanty, burning urine, yellow greasy tongue coating). This formula is warming and would worsen Heat conditions.

Avoid

Yin deficiency with Heat signs (night sweats, five-centre heat, red tongue with little coating). The warm nature of this formula can further damage Yin fluids.

Caution

Active exterior conditions such as colds or fevers. The formula should be stopped during febrile illness, as its warming, consolidating nature can trap pathogens.

Caution

Patients with serious chronic conditions including hypertension, heart disease, liver disease, diabetes, or kidney disease should use this formula only under professional supervision.

Avoid

Patients with urinary obstruction or structural urinary tract pathology. The formula reduces urinary output and could worsen obstruction.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe, but should be used under practitioner guidance during pregnancy. Wu Yao (Lindera root) has Qi-moving properties that are mildly stimulating, though it is not classically listed as a pregnancy-prohibited herb. Yi Zhi Ren and Shan Yao are not considered problematic. Some modern clinical reports in China have actually used Suo Quan Wan to treat threatened miscarriage (先兆流产) due to Kidney deficiency, but this must only be done under professional supervision. Pregnant women should consult a qualified practitioner before use.

Breastfeeding

No specific contraindications for breastfeeding have been identified. The three herbs in this formula (Yi Zhi Ren, Wu Yao, Shan Yao) are mild and food-grade in nature, with no known toxic components likely to transfer through breast milk in clinically significant amounts. However, as with all herbal medicines during breastfeeding, use under practitioner guidance is recommended. If the nursing infant develops any unusual symptoms (diarrhea, irritability, rash), discontinue and consult a practitioner.

Children

Suo Quan Wan is classically noted as being "especially effective for children" (小儿尤效) and has a long history of pediatric use for bedwetting. Modern patent medicine dosing typically recommends: children over age 5 take half the adult dose (approximately 3 pills of the capsule form, three times daily). For children under 5, practitioner guidance is essential and doses should be further reduced proportionally by body weight. The formula's mild composition (only three herbs, all with low toxicity profiles) makes it well-suited for pediatric use. Clinical reports have combined Suo Quan Wan with Sang Piao Xiao San for pediatric enuresis with reported effectiveness rates above 90%. The formula should not be given during acute febrile illness in children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Suo Quan Wan

Anticholinergic / antimuscarinic medications (e.g. oxybutynin, tolterodine, solifenacin): SQW has demonstrated effects on cholinergic and adrenergic signaling in the bladder. Using SQW alongside anticholinergic drugs may have additive effects on reducing bladder contractility. While this combination is used clinically in China, concurrent use should be monitored by a practitioner to avoid excessive urinary retention.

β3-adrenergic receptor agonists (e.g. mirabegron): Research shows SQW increases β3-adrenoreceptor sensitivity in the bladder. Combining SQW with mirabegron could theoretically potentiate bladder relaxation effects. Professional supervision is advised.

Diuretics: SQW's purpose is to reduce urinary frequency and volume. Concurrent use with diuretics creates a direct pharmacological conflict and may reduce the effectiveness of either therapy.

Antidiabetic medications: Some research involves SQW in diabetic bladder dysfunction models. While no direct interaction is documented, diabetic patients on glucose-lowering medications should inform their practitioner, as the formula's effects on fluid metabolism could theoretically influence hydration status.

Usage Guidance

Practical advice for getting the most out of Suo Quan Wan

Best time to take

Before meals (饭前服用), typically 30 minutes before meals, three times daily. Traditionally taken with lightly salted warm water to guide the formula's action into the Kidney channel.

Typical duration

Often taken for 2–4 weeks as an initial course, then reassessed. Chronic conditions (elderly incontinence, pediatric enuresis) may require 4–8 weeks or longer with periodic review.

Dietary advice

Avoid cold and raw foods (salads, iced drinks, raw fruit in excess), which further damage Kidney Yang and aggravate cold in the lower body. Avoid spicy, greasy, and heavily seasoned foods which can generate Damp-Heat and counteract the formula's intent. Favour warm, easily digested foods: congee, cooked root vegetables, soups, and warming spices like ginger and cinnamon in moderation. Walnuts, black sesame, and chestnuts are traditionally recommended to support Kidney Yang. Keep the lower back and abdomen warm, especially in cold weather. Reduce fluid intake close to bedtime if nighttime enuresis is the primary concern.

Suo Quan Wan originates from Jiào Zhù Fù Rén Liáng Fāng (校注妇人良方, Revised Fine Formulas for Women) Sòng dynasty, ~1237 CE (original text by Chén Zìmíng; annotated by Xuē Jǐ in the Míng dynasty)

Classical Texts

Key passages from the classical Chinese medical texts that first described Suo Quan Wan and its clinical use

《校注妇人良方》(Jiào Zhù Fù Rén Liáng Fāng):
「缩泉丸 治脬气虚寒,小便频数,或遗尿不止,小儿尤效。」
"Suo Quan Wan treats Bladder Qi deficiency-cold with frequent urination or incessant enuresis; it is especially effective for children."

Ming Dynasty — Wu Kun《医方考》(Yī Fāng Kǎo):
「脬气虚寒,小便频数,遗尿不止者,此方主之。脬气者,太阳膀胱之气也。膀胱之气,贵于冲和,邪气热之则便涩,邪气实之则不出;正气寒之则遗尿,正气虚之则不禁。」
"This formula governs Bladder Qi deficiency-cold with frequent urination and incessant enuresis. 'Bladder Qi' refers to the Qi of the Taiyang Bladder. The Bladder Qi values harmony: when pathogenic Heat invades, urination becomes difficult; when pathogenic excess blocks it, urine cannot exit; when upright Qi is cold, enuresis results; when upright Qi is deficient, urine cannot be restrained."

Qing Dynasty — Xu Dachun《医略六书·杂病证治》:
「乌药顺九天之气,敷气化于脬中;益智补先天之火,缩小便于水府;山药糊丸,淡盐汤下,乃以耑补脾阴兼益肾脏也。使脾肾两充,则阳化阴施,而精溺自分。此化气摄液之剂,为阳虚气不施化之耑方。」
"Wu Yao directs the Qi of the nine heavens, spreading Qi transformation within the Bladder; Yi Zhi Ren supplements the fire of the prenatal constitution, restraining urination at the Water Palace; Shan Yao as paste pills taken with lightly salted decoction specifically supplements Spleen Yin while also benefiting the Kidneys. When both Spleen and Kidney are replenished, Yang transforms and Yin distributes, and essence and urine naturally separate. This is a formula for transforming Qi and restraining fluids, specifically designed for Yang deficiency with failure of Qi transformation."

Historical Context

How Suo Quan Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Suo Quan Wan (缩泉丸, "Shut the Sluice Pill" or "Restrict the Fountain Pill") first appeared during the Southern Song Dynasty (1127–1279 CE). Its earliest recorded source is a matter of some debate: some authorities attribute it to Chen Ziming's (陈自明) Fu Ren Da Quan Liang Fang (妇人大全良方, "Complete Good Formulas for Women"), while others trace it to the Wei Shi Jia Cang Fang (魏氏家藏方). The version most widely studied today comes from Xue Ji's (薛己) Ming Dynasty revision, the Jiào Zhù Fù Rén Liáng Fāng (校注妇人良方). The formula also appears under the alternate name Gu Zhen Dan (固真丹, "Stabilize the True Elixir").

The formula's name is poetically evocative: "quán" (泉) means "spring" or "fountain," referring to the flow of urine, and "suō" (缩) means "to shrink" or "to restrain." The name thus captures the formula's purpose perfectly: to restrain an overflowing spring. Despite containing only two active medicinal ingredients (Yi Zhi Ren and Wu Yao, with Shan Yao serving as a binder and supplementary support), the formula has remained in continuous clinical use for over 700 years. It is listed in the Chinese Pharmacopoeia as an approved patent medicine and is one of the most commonly used traditional formulas for urinary disorders in China today.

Later physicians expanded its applications well beyond gynecology. Famous commentators including Wu Kun (吴昆) in the Yi Fang Kao (医方考) and Xu Dachun (徐大椿) in the Yi Lue Liu Shu (医略六书) provided influential analyses of the formula's mechanism. Modern clinical practice has further broadened its use to include neurogenic bladder, elderly urinary incontinence, stress urinary incontinence, and even as an adjunct in managing diabetic bladder dysfunction.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Suo Quan Wan

1

Effect of the Chinese traditional prescription Suo Quan Wan on TRPV1 expression in the bladder of rats with bladder outlet obstruction (Animal study, 2015)

Lai H, Tan B, Liang Z, Yan Q, Lian Q, Wu Q, Cao H. BMC Complementary and Alternative Medicine, 2015, 15:424.

This preclinical study found that SQW treatment restored bladder stability in rats with overactive bladder caused by bladder outlet obstruction. SQW significantly reduced the elevated expression of TRPV1 (a receptor involved in bladder sensory signaling) in bladder tissue, and corrected abnormal urodynamic parameters including bladder pressure and voiding efficiency.

2

Effect of Suo Quan Wan on the bladder function of aging rats based on the β-adrenoceptor (Animal study, 2017)

Liang Z, Yan Q, Cao H, et al. Experimental and Therapeutic Medicine, 2017, 13(6):3424-3432.

This study investigated SQW's effect on age-related bladder dysfunction in female rats. SQW enhanced bladder control, storage, and contraction ability in aging rats. The formula increased the sensitivity and expression of β3-adrenergic receptors in the bladder detrusor muscle, suggesting a mechanism for improving age-related lower urinary tract symptoms.

PubMed
3

Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9 (Animal study, 2019)

Wang J, Lian D, Yang X, Xu Y, Chen F, Lin W, Wang R, Tang L, Ren W, Fu L, Huang P, Cao H. Frontiers in Pharmacology, 2019, 10:552.

Using a type 2 diabetes mouse model, this study showed that SQW improved overactive bladder symptoms in early diabetic bladder dysfunction. SQW modulated expression of motor protein Myosin Va and transporter protein SLC17A9 in bladder tissue, suggesting it helps regulate both neurotransmitter vesicle transport and purinergic signaling in the bladder.

4

Suo Quan Wan ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression (Animal study, 2022)

Zhang Y, Zhang J, Hong M, Huang J, Xu S, Wang R, Zhou N, Huang P, Tan B, Cao H. Phytomedicine, 2022, 104:154265.

Building on earlier research, this study demonstrated that SQW ameliorated bladder overactivity in diabetic rats by regulating Myosin Va expression in bladder neurons. SQW rebalanced excitatory (ChAT, SP) and inhibitory (nNOS, VIP) neurotransmitter expression, supporting the formula's role in normalizing bladder nerve function.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.