Qing Yan Li Ge Tang

Clear the Throat and Benefit the Diaphragm Decoction · 清咽利膈汤

Also known as: Qing Yan Li Ge San (清咽利膈散, Clear the Throat and Benefit the Diaphragm Powder)

A classical formula used for severe sore throat, swollen tonsils, and throat infections caused by intense internal Heat. It works by clearing Heat and toxins from the upper body while gently purging accumulated Heat downward through the bowels, providing rapid relief for painful, swollen throat conditions with possible fever, irritability, and constipation.

Origin Hou Ke Zi Zhen Ji (《喉科紫珍集》, Purple Pearl Collection of Throat Medicine) — Qīng dynasty, first printed 1860 CE
Composition 14 herbs
Lian Qiao
King
Lian Qiao
Jin Yin Hua
King
Jin Yin Hua
Huang Qin
Deputy
Huang Qin
Huang Lian
Deputy
Huang Lian
Zhi Zi
Deputy
Zhi Zi
Xuan Shen
Deputy
Xuan Shen
Niu Bang Zi
Assistant
Niu Bang Zi
Bo He
Assistant
Bo He
+6
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Yan Li Ge Tang is designed to correct these specific patterns.

Why Qing Yan Li Ge Tang addresses this pattern

When external Wind-Heat invades and combines with pre-existing internal Stomach Heat, it flares upward along the Lung channel to attack the throat. This formula's Wind-dispersing herbs (Bo He, Jing Jie, Fang Feng, Niu Bang Zi) release the exterior pathogen, while the Heat-clearing core (Lian Qiao, Jin Yin Hua, Huang Qin) clears the Lung Heat that drives throat swelling. The purgative component prevents internal Heat from reinforcing the upper body inflammation.

A practitioner would look for one or more of these signs

Sore Throat

Severe, red, swollen throat that is painful on swallowing

Fever

Fever with possible slight chills at onset

Cough

Cough with yellow, sticky mucus

Headaches

Headache from Wind-Heat

Thirst

Thirst with desire for cold drinks

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Yan Li Ge Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Toxic-Heat Stomach Fire

TCM Interpretation

TCM views acute tonsillitis (called Ru E or "Milk Moth") as a condition where Heat toxins accumulate at the tonsils, which sit at the junction of the Lung and Stomach channels. The tonsils swell, redden, and may develop pus points when toxic Heat becomes severe. This is almost always tied to Stomach and Lung Heat: the Stomach channel directly passes through the throat, and when the Stomach harbors excess Heat (from rich food, alcohol, or external pathogens transforming into Heat), it flares upward to the tonsils. Constipation signals that the Heat has also affected the bowels.

Why Qing Yan Li Ge Tang Helps

Qing Yan Li Ge Tang directly targets the dual pathology of tonsillitis: Heat toxins in the throat and accumulated Heat in the Stomach and bowels. Lian Qiao and Jin Yin Hua resolve the toxic Heat causing tonsillar suppuration. Niu Bang Zi and Jie Geng specifically benefit the throat and reduce swelling. Huang Qin and Huang Lian drain the Fire from the Lung and Stomach that fuels the inflammation. Da Huang and Mang Xiao purge Heat downward through the bowels, breaking the cycle of constipation driving more Heat upward to the throat. This combination of clearing above and purging below makes it particularly well-suited for acute tonsillitis with both throat inflammation and digestive Heat signs.

Also commonly used for

Peritonsillar Abscess

Throat abscess conditions

Mouth Ulcers

Mouth sores from excessive internal Heat

Fever

Fever from upper respiratory tract infections with throat involvement

Constipation

Constipation accompanying throat infections from internal Heat

Gingivitis

Gum inflammation from Stomach Fire

Laryngitis

Acute laryngitis with Heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Yan Li Ge Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Yan Li Ge Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Yan Li Ge Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Yan Li Ge Tang works at the root level.

This formula addresses a condition where intense Heat has accumulated in the Stomach and Lungs, then flares upward to attack the throat. In TCM understanding, the throat is a passage shared by the Lung and Stomach channels, making it vulnerable when either organ harbors excess Heat. When internal Heat builds up (from dietary excess, external Wind-Heat invasion, or other causes), it blazes upward along these channels, scorching the throat and causing redness, swelling, and severe pain.

At the same time, this Heat congests the chest and diaphragm area, producing a feeling of fullness, irritability, and restlessness. Because the Stomach and Intestines are also affected, the Heat dries the fluids in the bowels, leading to constipation. The constipation itself then worsens the situation: with the normal downward route blocked, more Heat is forced upward. This creates a vicious cycle where Heat above and blocked stool below reinforce each other. The throat swelling may progress to include conditions like tonsillitis (known as "Milk Moth" or Ru E in TCM), throat obstruction (Hou Bi), or even throat abscess (Hou Yong).

The treatment strategy therefore must work from two directions simultaneously: clearing Heat and toxins from the throat above, while purging accumulated Heat downward through the bowels below. Additionally, because external Wind-Heat often triggers or accompanies this condition, dispersing the surface pathogen is also necessary.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and acrid (pungent) — bitter to clear Heat and drain Fire downward, acrid to disperse Wind and open the throat, with a salty note from Mang Xiao to soften hardness and purge.

Ingredients

14 herbs

The herbs that make up Qing Yan Li Ge Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Lian Qiao

Lian Qiao

Forsythia fruit

Dosage 3 - 5g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine

Role in Qing Yan Li Ge Tang

Clears Heat and resolves toxins, especially from the upper body. As a light, aromatic herb that floats upward, it targets Heat accumulation in the chest and throat area, serving as the primary Heat-clearing agent for this formula.
Jin Yin Hua

Jin Yin Hua

Honeysuckle flower

Dosage 3 - 5g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Heart, Stomach, Large Intestine

Role in Qing Yan Li Ge Tang

Powerfully clears Heat and resolves toxins, reinforcing Lian Qiao as a co-King herb. Particularly effective for toxic Heat manifesting as swelling and suppuration in the throat.
Deputies — Assists and enhances the King
Huang Qin

Huang Qin

Baical skullcap root

Dosage 3 - 5g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Qing Yan Li Ge Tang

Clears Heat from the Lung and upper body, reinforcing the formula's primary action on the chest and throat. Especially skilled at draining Fire from the upper and middle warmers.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 3 - 5g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Qing Yan Li Ge Tang

Drains Fire and resolves toxins, especially from the Heart and Stomach. Targets the internal Heat that gives rise to throat inflammation and ulceration.
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 3 - 5g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)

Role in Qing Yan Li Ge Tang

Clears Heat from all three warmers and guides Fire downward through the urine, providing an additional route for Heat elimination beyond the bowels.
Xuan Shen

Xuan Shen

Figwort root

Dosage 5 - 10g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Lungs, Stomach, Kidneys

Role in Qing Yan Li Ge Tang

Clears Heat, nourishes Yin, and resolves toxins. Protects the throat's delicate tissues from damage by intense Heat and prevents Yin fluids from being consumed by the Fire.
Assistants — Supports or moderates other herbs
Niu Bang Zi

Niu Bang Zi

Burdock fruit

Dosage 3 - 5g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Stomach

Role in Qing Yan Li Ge Tang

Disperses Wind-Heat and benefits the throat, with a specific affinity for reducing swelling and pain in throat conditions. Also helps to vent and disperse toxins outward.
Bo He

Bo He

Peppermint herb

Dosage 3 - 5g
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver

Role in Qing Yan Li Ge Tang

Disperses Wind-Heat from the head and throat, clears the head, and benefits the throat. Its light, aromatic quality helps vent pathogens outward from the surface.
Fang Feng

Fang Feng

Siler root

Dosage 3 - 5g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Qing Yan Li Ge Tang

Expels Wind and releases the exterior, helping to vent Heat outward through the body surface. Works with Bo He and Jing Jie to address the external Wind-Heat component.
Jing Jie

Jing Jie

Schizonepeta

Dosage 3 - 5g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver

Role in Qing Yan Li Ge Tang

Releases the exterior and disperses Wind, complementing Bo He and Fang Feng. Particularly useful for early-stage throat conditions involving external pathogenic factors.
Da Huang

Da Huang

Rhubarb root and rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium

Role in Qing Yan Li Ge Tang

Purges Heat downward through the bowels, draining accumulated Stomach and Intestinal Heat. This 'using purgation to clear Heat' strategy provides a crucial downward exit route for intense upper body Heat.
Mang Xiao

Mang Xiao

Mirabilite

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Stomach, Large Intestine
Preparation Dissolved into the strained decoction (冲服), not decocted with the other herbs

Role in Qing Yan Li Ge Tang

Softens hardness and purges Heat, reinforcing Da Huang's purgative action. Together they clear accumulated Heat from the Stomach and Intestines, relieving the constipation that often accompanies this pattern.
Envoys — Directs the formula to its target
Jie Geng

Jie Geng

Balloon flower root

Dosage 3 - 5g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Qing Yan Li Ge Tang

Directs the formula's actions upward to the throat. Opens and benefits the Lung, resolves Phlegm, and serves as the 'boat' that carries other medicinals to the throat region.
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 5g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Qing Yan Li Ge Tang

Harmonizes all the herbs in the formula. Also benefits the throat directly by soothing irritation and moderates the harshness of the purgative herbs (Da Huang and Mang Xiao).

Why This Combination Works

How the herbs in Qing Yan Li Ge Tang complement each other

Overall strategy

This formula adopts a dual approach of "clearing above and purging below" (清上泻下) to manage intense Heat that has accumulated in the Stomach and Lung channels and flared upward to the throat. By simultaneously clearing Heat and toxins from the throat, dispersing Wind-Heat from the surface, and purging Heat downward through the bowels, the formula attacks the problem from multiple angles.

King herbs

Lian Qiao (Forsythia) and Jin Yin Hua (Honeysuckle flower) serve as the primary Heat-clearing and toxin-resolving pair. Lian Qiao is light and upward-moving, making it especially effective for clearing Heat from the chest and upper body. Jin Yin Hua powerfully resolves toxic Heat and is particularly valued for swelling and suppurative conditions. Together they form the core attack on the Heat toxins causing throat inflammation.

Deputy herbs

Huang Qin and Huang Lian provide strong bitter-cold Fire-draining action targeting the Lung and Stomach respectively, reinforcing the Kings' Heat-clearing effect. Zhi Zi clears Heat from all three warmers and channels it downward via urination, adding a second elimination route. Xuan Shen serves a protective role: it clears Heat while nourishing Yin, preventing the intense Fire from consuming the throat's delicate fluids and tissues.

Assistant herbs

The Wind-dispersing trio of Niu Bang Zi, Bo He, and Jing Jie with Fang Feng releases exterior Wind-Heat and directly benefits the swollen throat (reinforcing assistants). Niu Bang Zi is especially notable for its throat-specific action. Da Huang and Mang Xiao form the purgative pair: by clearing Heat downward through the bowels, they relieve the constipation that traps Heat inside the body and break the cycle of Heat accumulating upward (counteracting assistants). This "using purgation to clear Heat" strategy mirrors the approach seen in Liang Ge San (Cool the Diaphragm Powder).

Envoy herbs

Jie Geng acts as a guiding herb that directs the formula's actions upward to the throat, functioning like a "boat" that carries the other medicinals to their target. Gan Cao harmonizes the formula, soothes the throat directly, and moderates the harshness of Da Huang and Mang Xiao to protect the Stomach.

Notable synergies

Lian Qiao paired with Jin Yin Hua creates a powerful Heat-clearing and detoxifying combination that is greater than either alone. Da Huang with Mang Xiao provides the classic purgative pairing that not only relieves constipation but draws Heat downward away from the throat. Jie Geng paired with Gan Cao is a time-honored combination for throat conditions, as Jie Geng opens the Lung and directs upward while Gan Cao soothes and resolves toxins locally in the throat.

How to Prepare

Traditional preparation instructions for Qing Yan Li Ge Tang

Decoct all herbs except Xuan Ming Fen (Glauber's salt) in approximately 400 ml of water. Bring to a boil, then simmer until roughly 200 ml remains. Strain the decoction, then dissolve the Xuan Ming Fen into the warm liquid before drinking. Take after meals, one dose per day divided into two servings.

Common Modifications

How practitioners adapt Qing Yan Li Ge Tang for specific situations

Added
She Gan

6 - 9g, clears Heat and benefits the throat, reduces swelling

Shan Dou Gen

6 - 9g, strongly clears toxic Heat from the throat

She Gan and Shan Dou Gen are both powerful throat-specific Heat-clearing herbs that enhance the formula's ability to reduce severe throat swelling and break down toxic accumulation.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Yan Li Ge Tang should not be used or requires extra caution

Avoid

Pregnancy. This formula contains Da Huang (Rhubarb) and Mang Xiao (Glauber's Salt), both of which are strong purgatives that can stimulate uterine contractions and potentially cause miscarriage.

Avoid

Sore throat or pharyngitis caused by Yin deficiency with deficiency-Fire rising, without true excess Heat. This formula's cold and purgative nature could further damage Yin and weaken the body.

Avoid

Patients with chronic diarrhea, loose stools, or Spleen and Stomach deficiency-Cold. The purgative herbs Da Huang and Mang Xiao, combined with the overall cold nature of the formula, can severely aggravate digestive weakness.

Caution

Throat pain without constipation or signs of interior Heat accumulation. The purgative action of the formula is unnecessary and potentially harmful when the bowels are already functioning normally.

Caution

Elderly or physically weak patients. The strongly purging and cold nature of this formula may be too drastic. Dosage should be significantly reduced or an alternative, milder formula considered.

Caution

Patients currently experiencing heavy menstrual bleeding. The Blood-moving and purgative properties of Da Huang may worsen bleeding.

Caution

Prolonged use beyond the acute phase. Once the excess Heat pattern has resolved and symptoms have improved, the formula should be discontinued to avoid injuring Stomach Qi and body fluids.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. This formula contains Da Huang (Rhubarb) and Mang Xiao (Glauber's Salt/Mirabilite), both of which are potent purgatives classified among the traditionally forbidden herbs in pregnancy. Da Huang promotes downward movement of Qi and Blood, and Mang Xiao has strong cathartic effects. Together they can stimulate intestinal and uterine smooth muscle contractions, posing a risk of miscarriage or premature labor. Pregnant women with sore throat conditions should seek alternative formulas that do not contain purgative or Blood-moving herbs.

Breastfeeding

Use with caution during breastfeeding. Da Huang (Rhubarb) contains anthraquinone compounds (such as emodin and rhein) that can be transferred through breast milk, potentially causing loose stools or diarrhea in nursing infants. Mang Xiao (Glauber's Salt) also has strong purgative properties. Huang Lian (Coptis) is very bitter and cold, and its alkaloids (especially berberine) may also transfer into breast milk. If use is clinically necessary for an acute condition, the treatment course should be kept as short as possible and the infant monitored for digestive disturbance. Consult a qualified practitioner before use.

Children

This formula has historical precedent for pediatric use, particularly for childhood tonsillitis (乳蛾, rǔ é). However, the purgative herbs Da Huang and Mang Xiao require significant dose reduction in children. As a general guideline: children under 6 years should receive roughly one-quarter to one-third of the adult dose; children aged 6-12 roughly one-half. The purgative components should be reduced first and their effect monitored closely, as children's digestive systems are more delicate (described in TCM as "Spleen often insufficient"). Once bowel movements become loose or the acute Heat signs resolve, the formula should be stopped promptly. A qualified pediatric TCM practitioner should supervise dosing. Not recommended for infants under 1 year.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Yan Li Ge Tang

Da Huang (Rhubarb) and Mang Xiao (Glauber's Salt): These strong purgatives can accelerate gastrointestinal transit and reduce absorption of concurrently taken oral medications. Any oral drugs should be taken at least 2 hours apart from this formula. Da Huang's anthraquinones may also interact with cardiac glycosides (e.g. digoxin) by causing potassium loss through prolonged diarrhea, increasing the risk of digoxin toxicity.

Gan Cao (Licorice): Contains glycyrrhizin, which can cause sodium retention and potassium loss. This may interact with antihypertensives (reducing their effectiveness), diuretics (compounding potassium loss, especially with thiazides or loop diuretics), corticosteroids (additive mineralocorticoid effects), and cardiac glycosides (increased toxicity risk from hypokalemia).

Huang Lian (Coptis) and Huang Qin (Scutellaria): Both contain compounds with known effects on drug-metabolizing enzymes. Berberine from Huang Lian can inhibit CYP2D6, CYP2C9, and CYP3A4 enzymes, potentially increasing plasma levels of drugs metabolized by these pathways (e.g. certain statins, warfarin, cyclosporine). Huang Qin's baicalin may interact with antibiotics by altering gut flora.

Anticoagulants and antiplatelet agents: Da Huang has mild Blood-activating properties and may have an additive effect with warfarin or other anticoagulants, increasing bleeding risk. INR should be monitored if concurrent use is necessary.

Usage Guidance

Practical advice for getting the most out of Qing Yan Li Ge Tang

Best time to take

30 minutes to 1 hour after meals, 2–3 times daily. Taking after meals helps protect the Stomach from the formula's cold and purgative nature.

Typical duration

Acute use: 3–5 days, reassessed as symptoms improve. Discontinue once Heat signs resolve and bowels normalize.

Dietary advice

While taking this formula, avoid greasy, fried, and rich foods that generate internal Heat and Dampness, as these can worsen throat inflammation and counteract the formula's clearing effect. Spicy and pungent foods (chili, pepper, alcohol, strong spices) should also be avoided, as they further inflame the throat. Cold and raw foods are generally acceptable in moderation given the formula's cold nature, but ice-cold drinks should still be limited to avoid shocking the Stomach. Favor light, easily digestible foods: clear soups, congee (rice porridge), steamed vegetables, and cooling fruits like pears and watermelon. Adequate warm water intake is important to stay hydrated and support the throat. Avoid smoking and alcohol completely during treatment.

Qing Yan Li Ge Tang originates from Hou Ke Zi Zhen Ji (《喉科紫珍集》, Purple Pearl Collection of Throat Medicine) Qīng dynasty, first printed 1860 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Yan Li Ge Tang and its clinical use

Formula analysis from classical commentary:

The formula is analyzed as a combination of three therapeutic strategies: dispersing Wind from the exterior, clearing Heat and toxins from the interior, and purging Fire downward through the bowels. As classical commentaries explain, the Wind-dispersing herbs (Jing Jie, Fang Feng, Bo He) release the exterior, while the Heat-clearing herbs (Lian Qiao, Jin Yin Hua, Niu Bang Zi, Jie Geng, Huang Qin, Huang Lian, Zhi Zi) address toxin-Heat in the upper and middle Jiao. The purgative pair of Da Huang and Mang Xiao drives accumulated Heat downward through the bowels, while Xuan Shen clears Heat and benefits the throat while generating fluids.

Classical indication summary:

「风热邪毒壅塞肺胃所引起的发热恶寒,头痛、咽喉肿痛、吞咽不利、烦躁、口渴饮冷、溲赤、大便秘结、舌红苔黄腻」
Translation: "Fever with chills, headache, sore and swollen throat, difficulty swallowing, restlessness, thirst with a desire for cold drinks, dark urine, constipation, red tongue with yellow greasy coating — all caused by Wind-Heat and toxic pathogens obstructing the Lung and Stomach."

Historical Context

How Qing Yan Li Ge Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Yan Li Ge Tang (清咽利膈汤, "Clear the Throat and Enable the Diaphragm Decoction") is most closely associated with the Hou Ke Zi Zhen Ji (《喉科紫珍集》), a specialized throat medicine (喉科) text from the Qing dynasty. This work exists in two main editions: the first printed in 1860 under the title Jing Yan Hou Ke Zi Zhen Ji (《经验喉科紫珍集》), attributed to Dou shi of Yanshan and compiled by Zhu Xiangyu; and the second printed in 1874 as Hou Zheng Quan Ke Zi Zhen Ji (《喉症全科紫珍集》). Both editions describe 72 throat conditions with illustrated case studies, external treatment methods, and herbal prescriptions.

The formula is structurally a synthesis of several classical strategies: it combines the Wind-Heat dispersing approach of Yin Qiao San with the purgative method of Tiao Wei Cheng Qi Tang, supplemented by Fire-clearing herbs from Huang Lian Jie Du Tang (minus Huang Bai), along with Xuan Shen and Fang Feng. This multi-layered design reflects the Qing-era emphasis on treating acute febrile conditions affecting the throat from both the exterior and interior simultaneously. Multiple variant formulas sharing the same name appear in other texts, including a pediatric version in You Ke Jin Zhen (《幼科金针》) for childhood tonsillitis and another in Wai Ke Xuan Yao (《外科选要》) for throat pain with constipation.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Qing Yan Li Ge Tang

1

In Vitro Study: Qing Yan Li Ge Tang Induces Autophagic Cell Death in Nasopharyngeal Carcinoma Cells via PI3K/Akt/mTOR Pathway (2021)

Yang CH, Tung KL, Wu YT, Liu C, Lin SC, Yang CC, Wu CH, Chang HY, Wu SY, Huang BM, Lan YY. Evidence-Based Complementary and Alternative Medicine, 2021, Article 6528474.

This laboratory study investigated whether Qing Yan Li Ge Tang (QYLGT) has anticancer activity against nasopharyngeal carcinoma (NPC) cells. Researchers found that QYLGT inhibited NPC cell viability and reduced colony formation ability. The formula also promoted formation of intracellular vacuoles and increased the expression of autophagy-related proteins (Atg3, Atg6, Atg12-Atg5). The study suggested that QYLGT induces cancer cell death through autophagy via the PI3K/Akt/mTOR signaling pathway. This is a preclinical (cell-based) study and does not demonstrate clinical efficacy in humans.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.