Qi Lin Wan

Qilin Pill · 麒麟丸

Also known as: Zhu Yun Yu Er Wan (助孕育儿丸)

A classical fertility-support formula that nourishes the Kidneys, fills Essence, and strengthens Qi and Blood. It is used for both men and women experiencing reproductive difficulties linked to Kidney deficiency and insufficient Qi and Blood, such as low sperm quality, irregular periods, fatigue, and weak lower back.

Origin Dan Xi Xin Fa (丹溪心法), based on the reproductive theory of Zhu Danxi — Yuan dynasty (元代), ~1347 CE
Composition 15 herbs
Zh
King
Zhi He Shou Wu (Prepared Fleeceflower Root)
Mo Han Lian
King
Mo Han Lian
Yin Yang Huo
Deputy
Yin Yang Huo
Tu Si Zi
Deputy
Tu Si Zi
Suo Yang
Deputy
Suo Yang
Sang Shen
Deputy
Sang Shen
Gou Qi Zi
Deputy
Gou Qi Zi
Fu Pen Zi
Deputy
Fu Pen Zi
+7
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qi Lin Wan is designed to correct these specific patterns.

Why Qi Lin Wan addresses this pattern

Kidney Essence Deficiency is the primary pattern this formula targets. When Kidney Essence is depleted, the fundamental material needed for reproductive function is insufficient. The King herbs Zhi He Shou Wu and Mo Han Lian directly replenish Liver and Kidney Yin and Essence. The Deputy group of Gou Qi Zi, Sang Shen, Fu Pen Zi, and Tu Si Zi further fills and secures Essence. The Yang-warming Deputies (Yin Yang Huo, Suo Yang) support Essence production by ensuring Kidney Yang can transform and generate Essence. This comprehensive approach addresses Essence deficiency from both its Yin and Yang roots.

A practitioner would look for one or more of these signs

Low Back Pain

Dull, aching lower back and weak knees from Kidney Essence depletion

Male Infertility

Low sperm count, poor motility, thin semen

Premature Ejaculation

Due to Kidney failing to secure Essence

Fatigue

Deep, constitutional tiredness with lack of vitality

Irregular Menstruation

Scanty or delayed periods in women from insufficient Essence and Blood

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qi Lin Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, male infertility is closely linked to the Kidney system, which governs reproduction and stores Essence (Jing). Sperm is considered a manifestation of Kidney Essence, so when Essence is depleted, sperm quality naturally suffers, with low counts, poor motility, or abnormal morphology. The Spleen also plays a supporting role, as it produces the Qi and Blood that nourish the Kidneys. Many men with infertility show signs of both Kidney weakness (low back soreness, weak knees, reduced libido) and Spleen-Qi deficiency (fatigue, poor appetite, pale complexion). Liver Qi stagnation from stress can further compound the problem by disrupting Qi flow to the reproductive organs.

Why Qi Lin Wan Helps

Qi Lin Wan directly addresses the Kidney Essence deficiency at the heart of male infertility. Zhi He Shou Wu, Mo Han Lian, Gou Qi Zi, and Sang Shen replenish the Yin and Blood foundation of Essence, while Yin Yang Huo, Tu Si Zi, and Suo Yang warm Kidney Yang to support the active generation of sperm. Fu Pen Zi astringes and secures the Essence being produced. The Qi-tonifying group of Dang Shen, Huang Qi, and Shan Yao ensures the Spleen generates enough postnatal Qi and Blood to sustain Kidney function. Dan Shen promotes Blood circulation to the reproductive organs, while Yu Jin and Qing Pi keep Qi flowing smoothly to prevent stress-related stagnation from undermining sperm production. Animal studies have confirmed that this formula can increase sperm count and improve sperm motility, and meta-analyses of clinical trials have found it effective for treating oligospermia and asthenospermia.

Also commonly used for

Premature Ejaculation

Due to Kidney failing to secure Essence

Irregular Menstruation

Scanty or delayed menses from Blood and Essence deficiency

Low Back Pain

Chronic dull lumbar ache from Kidney deficiency

Fatigue

Constitutional tiredness from combined Qi, Blood, and Essence depletion

Diminished Ovarian Reserve

Kidney Essence and Qi deficiency affecting ovarian function

Polycystic Ovary Syndrome

When presenting with Kidney deficiency and Blood stasis patterns

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qi Lin Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qi Lin Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qi Lin Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qi Lin Wan works at the root level.

This formula addresses a complex deficiency pattern centered on the Kidneys but involving the Spleen and Liver. In TCM, the Kidneys store Essence (Jing), which is the material foundation for reproductive function in both men and women. When Kidney Essence becomes depleted through overwork, aging, chronic illness, or constitutional weakness, the reproductive system loses its driving force. In men, this manifests as thin or scanty semen, low sperm vitality, erectile dysfunction, or premature ejaculation. In women, it shows as irregular periods, poor egg quality, or difficulty conceiving.

However, the problem rarely stays confined to the Kidneys alone. Essence depends on Blood to nourish it, and Blood production depends on a healthy Spleen and Stomach (the digestive system). When the Spleen is weak, it cannot generate sufficient Qi and Blood from food, which means the Kidneys receive inadequate nourishment. This creates a downward cycle: depleted Kidney Essence weakens the body's vitality, the weakened body cannot produce enough Blood and Qi, and the Kidneys become further depleted. Patients typically show signs of both Kidney deficiency (sore lower back, weak knees, low libido) and Qi-Blood deficiency (pale complexion, fatigue, dizziness).

Additionally, when the body is full of heavy tonifying substances but Qi flow is sluggish, stagnation can develop. The Liver governs the smooth flow of Qi, and Liver Qi stagnation can further impair reproductive function by disrupting the menstrual cycle in women and compromising sperm quality in men. This formula addresses all three dimensions: it replenishes the Kidney's depleted Essence, strengthens Spleen-based Qi and Blood production, and ensures Liver Qi flows freely so that stagnation does not undermine the tonification.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet and slightly bitter, with mild sourness. Sweet to tonify Qi and Blood, bitter to direct downward and consolidate Kidney Essence, sour to astringently retain Essence.

Channels Entered

Ingredients

15 herbs

The herbs that make up Qi Lin Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Zh

Zhi He Shou Wu (Prepared Fleeceflower Root)

Dosage 10 - 15g

Role in Qi Lin Wan

Nourishes the Liver and Kidneys, replenishes Essence and Blood. As the primary Yin-nourishing herb, it establishes the foundation of Blood and Essence supplementation for the entire formula.
Mo Han Lian

Mo Han Lian

Eclipта herb (False Daisy)

Dosage 10 - 15g
Temperature Cold
Taste Sweet (甘 gān), Sour (酸 suān)
Organ Affinity Liver, Kidneys

Role in Qi Lin Wan

Nourishes the Liver and Kidneys and enriches Yin. Works alongside Zhi He Shou Wu to form the Yin-nourishing core of the formula, reinforcing the production of Essence and Blood.
Deputies — Assists and enhances the King
Yin Yang Huo

Yin Yang Huo

Epimedium leaf

Dosage 9 - 15g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Qi Lin Wan

Warms Kidney Yang and strengthens reproductive function. Balances the formula's Yin-nourishing focus with Yang-tonifying action, embodying the principle that 'Yin gains from Yang's support so the source never runs dry.'
Tu Si Zi

Tu Si Zi

Chinese Dodder Seed

Dosage 9 - 15g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Spleen

Role in Qi Lin Wan

Tonifies both Kidney Yin and Yang while securing Essence. A balanced Kidney tonic that bridges the Yin and Yang aspects of the formula and supports reproductive function in both men and women.
Suo Yang

Suo Yang

Cynomorium herb

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Large Intestine

Role in Qi Lin Wan

Warms the Kidneys and supplements Yang, strengthens sinews and nourishes Essence. Reinforces the Yang-warming action of Yin Yang Huo while also moistening the intestines.
Sang Shen

Sang Shen

Mulberry fruit

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān), Sour (酸 suān)
Organ Affinity Heart, Liver, Kidneys

Role in Qi Lin Wan

Nourishes Yin and Blood, enriches the Liver and Kidneys. Supports the King herbs in replenishing Essence and Blood without being overly cloying.
Gou Qi Zi

Gou Qi Zi

Chinese Wolfberry Fruit

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs

Role in Qi Lin Wan

Nourishes the Liver and Kidneys and enriches Essence. A gentle dual-action tonic that replenishes both Yin and Blood to support the formula's core strategy.
Fu Pen Zi

Fu Pen Zi

Chinese raspberry fruit

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān), Sour (酸 suān)
Organ Affinity Liver, Kidneys, Urinary Bladder

Role in Qi Lin Wan

Astringes Essence and secures the Kidneys. Helps consolidate the Kidney Essence being generated by other herbs, preventing its leakage through seminal emission or excessive urination.
Assistants — Supports or moderates other herbs
Dang Shen

Dang Shen

Codonopsis root

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Qi Lin Wan

Tonifies Spleen Qi to strengthen the postnatal source of Qi and Blood production. Ensures that the replenishment of Essence and Blood is sustained through robust digestive function.
Huang Qi

Huang Qi

Astragalus root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Qi Lin Wan

Strongly tonifies Qi and supports the Spleen. Works with Dang Shen and Shan Yao to reinforce the middle burner, ensuring that the production of Qi and Blood is sufficient to nourish the Kidneys.
Shan Yao

Shan Yao

Chinese yam

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Qi Lin Wan

Tonifies the Spleen and Kidneys simultaneously. Bridges the postnatal (Spleen) and prenatal (Kidney) systems to create a complete cycle of Essence and Qi replenishment.
Dan Shen

Dan Shen

Red sage root

Dosage 9 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Pericardium

Role in Qi Lin Wan

Invigorates Blood and nourishes Blood simultaneously. Prevents the rich tonifying herbs from creating stagnation, and supports Blood circulation to the reproductive organs.
Bai Shao

Bai Shao

White peony root

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Qi Lin Wan

Nourishes Blood, preserves Yin, and softens the Liver. Helps regulate menstruation in women and tempers the formula's warming herbs with its cooling, astringent nature.
Envoys — Directs the formula to its target
Yu Jin

Yu Jin

Turmeric tuber

Dosage 6 - 12g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Lungs

Role in Qi Lin Wan

Moves Qi and invigorates Blood, resolves stagnation. Prevents the formula's heavy tonifying nature from causing Qi stagnation and ensures smooth Qi flow throughout.
Qing Pi

Qing Pi

Green tangerine peel

Dosage 3 - 9g
Temperature Warm
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Stomach

Role in Qi Lin Wan

Spreads Liver Qi and breaks up stagnation. Together with Yu Jin, it ensures the formula remains dynamic rather than stagnant, and supports the Liver's role in governing the smooth flow of Qi needed for reproductive health.

Why This Combination Works

How the herbs in Qi Lin Wan complement each other

Overall strategy

The formula simultaneously replenishes Kidney Essence from both its Yin and Yang aspects, supports the Spleen to generate Qi and Blood as ongoing fuel, and uses Qi-moving herbs to prevent stagnation from the many tonifying ingredients. This three-pronged approach addresses the root deficiency while keeping the formula dynamic and well-balanced.

King herbs

Zhi He Shou Wu (Prepared Fleeceflower Root) and Mo Han Lian (Eclipta) serve as the King pair. Both are Liver-Kidney tonics that nourish Yin, replenish Essence, and enrich Blood. They establish the formula's core direction of building up the depleted material foundation needed for fertility. Their combined action ensures that the Yin and Blood aspects of Kidney Essence are thoroughly addressed.

Deputy herbs

The Deputies fall into two functional groups. The Yang-warming group of Yin Yang Huo, Tu Si Zi, and Suo Yang complements the Yin-nourishing Kings by adding Kidney Yang support, reflecting the classical principle that Yin depends on Yang for its generation. The Yin-nourishing group of Sang Shen, Gou Qi Zi, and Fu Pen Zi reinforces the Kings' Essence-filling action while Fu Pen Zi adds an astringent quality that prevents Essence from leaking away.

Assistant herbs

Dang Shen, Huang Qi, and Shan Yao form a Spleen-tonifying trio (reinforcing assistants) that ensures robust postnatal Qi and Blood production to continuously replenish the Kidneys. Dan Shen invigorates Blood to prevent stasis from forming amid heavy tonification. Bai Shao nourishes Blood and preserves Yin, providing a restraining assistant role that softens the warming herbs and supports menstrual regulation.

Envoy herbs

Yu Jin and Qing Pi serve as the formula's Qi-moving envoys. In a formula dominated by rich, heavy tonifying substances, these two herbs are critical for maintaining free Qi flow. They spread Liver Qi, break up potential stagnation, and ensure that the nourishing substances are properly distributed throughout the body rather than accumulating and causing blockage. This pairing ensures the formula remains balanced between supplementation and movement.

Notable synergies

The Yin-Yang pairing of He Shou Wu and Mo Han Lian (Yin-nourishing) with Yin Yang Huo and Suo Yang (Yang-warming) creates a dual-supplementation dynamic where Yin and Yang support each other's generation. The Dang Shen, Huang Qi, and Shan Yao trio ensures the prenatal Kidney Essence is continuously fed by postnatal Spleen Qi. The Yu Jin and Qing Pi pair within an otherwise purely tonifying formula elegantly prevents stagnation and embodies the formula's philosophy of combining stillness (supplementation) with movement (Qi regulation).

How to Prepare

Traditional preparation instructions for Qi Lin Wan

The modern Qi Lin Wan is commercially produced as concentrated pills (浓缩丸), appearing as small brownish-black pills with a faint aroma and a slightly sour and slightly bitter taste. It is taken orally.

Standard dosage: 6 grams per dose, taken 2 to 3 times daily. If oral dryness or excessive dreaming occurs after taking the pills, they may be swallowed with lightly salted water or honey water. If stomach discomfort occurs when taken on an empty stomach, the pills can be taken after meals instead.

Common Modifications

How practitioners adapt Qi Lin Wan for specific situations

Added
6 - 9g, melted separately, to strongly warm Kidney Yang and nourish Essence
Du Zhong

9 - 15g, to warm the Kidneys and strengthen the lower back

When Kidney Yang deficiency predominates with clear cold signs, adding stronger Yang-warming and Essence-nourishing substances enhances the formula's warming capacity beyond what Yin Yang Huo and Suo Yang alone provide.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qi Lin Wan should not be used or requires extra caution

Avoid

Active fever or common cold (感冒发热). The formula's tonifying and warming nature can trap pathogenic factors and worsen exterior conditions. Treatment of any acute febrile or infectious illness should take priority before resuming this formula.

Caution

Yin deficiency with strong Heat signs (阴虚火旺), such as pronounced night sweats, hot flashes, dry mouth, and a red tongue with little coating. The formula contains warm Kidney-Yang tonifying herbs like Yin Yang Huo and Suo Yang that can aggravate internal Heat in these patients.

Caution

Dampness or Phlegm obstruction in the middle burner, presenting with a thick greasy tongue coating, abdominal distension, nausea, or poor appetite. The rich, cloying nature of the tonic herbs can worsen Dampness stagnation.

Caution

Liver Qi stagnation with significant Heat, presenting with irritability, bitter taste in the mouth, red eyes, and headaches. While the formula contains Yu Jin and Qing Pi for Qi movement, the overall tonifying character may not be appropriate when Liver Fire is dominant.

Avoid

Known allergy or hypersensitivity to any of the 15 component herbs. Discontinue immediately if any allergic reaction occurs.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Suo Yang (Cynomorium), Yin Yang Huo (Epimedium), and Dan Shen (Salvia miltiorrhiza), all of which have pharmacological effects on the reproductive and hormonal systems. Dan Shen in particular has blood-activating properties that may pose a risk during pregnancy. Zhi He Shou Wu (processed Polygonum) also warrants caution due to potential hepatotoxicity concerns. This formula is intended to support conception, not to be taken once pregnancy is confirmed. Women should discontinue use immediately upon becoming pregnant and consult their healthcare provider.

Breastfeeding

Caution is advised during breastfeeding. While no specific adverse effects on breastfeeding have been formally documented, several herbs in the formula warrant careful consideration. Zhi He Shou Wu (processed Polygonum multiflorum) has known hepatotoxicity concerns, and its metabolites could theoretically pass into breast milk. Suo Yang and Yin Yang Huo have hormonal-modulating effects that could potentially affect lactation. Dan Shen activates blood circulation, which may also have implications. The formula's safety during breastfeeding has not been established through clinical studies. Women who are breastfeeding should consult a qualified practitioner before use.

Children

Qi Lin Wan is not intended for pediatric use. The formula is designed specifically for adults with Kidney deficiency and Essence depletion affecting reproductive function, which are conditions of the mature reproductive system. Children and adolescents whose reproductive and endocrine systems are still developing should not take this formula. The hormonal-modulating effects of ingredients such as Yin Yang Huo (Epimedium), Suo Yang (Cynomorium), and Tu Si Zi (Cuscuta) could be inappropriate for immature physiology. No clinical studies have evaluated its safety or efficacy in children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qi Lin Wan

Hormonal medications: The formula has demonstrated effects on sex hormones, including increasing serum estradiol and testosterone levels. It may interact with hormone replacement therapy (HRT), oral contraceptives, anti-estrogen drugs (e.g. clomiphene, tamoxifen), or testosterone supplementation. Concurrent use should be monitored by a healthcare provider.

Anticoagulants and antiplatelet drugs: Dan Shen (Salvia miltiorrhiza) in the formula is well documented to potentiate the effects of warfarin and other blood-thinning medications. Patients on anticoagulant therapy (warfarin, heparin) or antiplatelet agents (aspirin, clopidogrel) should use this formula with caution and under medical supervision, as the risk of bleeding may increase.

Hepatotoxicity concerns: Zhi He Shou Wu (processed Polygonum multiflorum) has been associated with liver injury in clinical reports. Patients taking other potentially hepatotoxic medications (e.g. acetaminophen, statins, methotrexate, certain antifungals) should exercise caution and have liver function monitored.

Usage Guidance

Practical advice for getting the most out of Qi Lin Wan

Best time to take

Taken 2 to 3 times daily, preferably on an empty stomach. If stomach discomfort occurs, switch to taking after meals.

Typical duration

Typically taken for 12 weeks (3 months) as one treatment course, corresponding to a full spermatogenesis cycle. May be extended with practitioner guidance.

Dietary advice

Avoid excessive cold and raw foods, iced beverages, and greasy or heavily processed foods, as these can impair Spleen function and hinder the absorption of the formula's tonic properties. Favor warm, nourishing foods that support Kidney and Spleen function, such as black beans, walnuts, sesame seeds, lamb, bone broth, goji berries, and dark leafy greens. Limit alcohol and coffee intake, as these can deplete Kidney Essence and generate Heat, working against the formula's therapeutic goals. During the treatment course, maintain regular eating times and avoid overeating, which can create Dampness and obstruct the middle burner.

Qi Lin Wan originates from Dan Xi Xin Fa (丹溪心法), based on the reproductive theory of Zhu Danxi Yuan dynasty (元代), ~1347 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qi Lin Wan and its clinical use

The modern Qi Lin Wan draws on the principles described in the Dan Xi Xin Fa (丹溪心法) by Zhu Danxi, which discusses the treatment of infertility through Kidney supplementation and Essence replenishment. The formula is also known by its classical alias 助孕育儿丸 (Zhu Yun Yu Er Wan, "Aid Pregnancy and Child-Rearing Pill").

The name "Qi Lin" (麒麟, the mythical Qilin creature) alludes to the Chinese folk tradition of "Qi Lin Song Zi" (麒麟送子), meaning "the Qilin delivers children," reflecting the formula's primary purpose of promoting fertility and reproductive health.

Historical Context

How Qi Lin Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qi Lin Wan traces its theoretical roots to the medical thought of Zhu Danxi (朱丹溪, 1281-1358), one of the four great physicians of the Jin-Yuan medical era and founder of the Nourishing Yin school (滋阴学派). Its formulation principles appear in the Dan Xi Xin Fa (丹溪心法), a text compiled by Zhu Danxi's disciples including Dai Yuanli and Zhao Yide around 1347 and later edited and expanded. The formula is also known by its classical name 助孕育儿丸 ("Aid Pregnancy and Child-Rearing Pill").

The name "Qi Lin" (麒麟) refers to the mythical Qilin, a benevolent creature in Chinese folklore strongly associated with the blessing of children. The tradition of "Qi Lin Song Zi" (麒麟送子, "the Qilin delivers children") is deeply embedded in Chinese culture, making the name a poetic expression of the formula's core purpose: promoting fertility in both men and women. The modern standardized formulation with its 15-herb composition was developed and approved as a patent Chinese medicine by the China Food and Drug Administration, becoming one of the most widely used TCM formulas for treating male and female infertility in contemporary Chinese clinical practice.

In recent decades, Qi Lin Wan has been the subject of extensive modern research, including multicenter randomized controlled trials for male oligoasthenospermia and preclinical studies on premature ovarian insufficiency, placing it among the more rigorously studied traditional fertility formulas.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Qi Lin Wan

1

Multicenter Randomized Double-Blind Controlled Clinical Trial of Qilin Pills for Idiopathic Oligoasthenospermia (2017)

Mao JM, Jiang H, Wang CH, et al. Zhonghua Nan Ke Xue, 2017, 23(3): 251-255.

This rigorous double-blind RCT enrolled 216 infertile men with low sperm count and motility, comparing Qilin Pills (6g three times daily) to Wuzi Yanzong Pills over 12 weeks. The Qilin Pill group showed significant time-dependent improvements in sperm motility, total sperm count, and count of progressively motile sperm at 4, 8, and 12 weeks compared to baseline. No obvious adverse events were reported.

PubMed
2

Meta-Analysis of Randomized Controlled Trials: Adjuvant Treatment with Qilin Pill for Men with Oligoasthenospermia (2017)

Jin X, Man C, Gong D, Fan Y. Phytotherapy Research, 2017, 31(9): 1291-1297.

This meta-analysis pooled data from 8 RCTs involving 778 patients. Adjunctive Qilin Pill therapy significantly improved semen volume, sperm concentration, sperm motility, grade A sperm percentage, serum testosterone levels, and pregnancy rate compared to controls. The pregnancy rate was 46% higher in the Qilin Pill group. However, FSH and LH levels did not change significantly.

Link
3

Preclinical Study: Qilin Pills Alleviate Oligoasthenospermia by Inhibiting Bax-Caspase-9 Apoptosis Pathway in Rat Testes (2018)

Zhang K, Ge Z, Fu L, et al. Oncotarget, 2018, 9(31): 21770-21782.

Using a rat model of oligoasthenospermia induced by tripterygium glycosides, this study found that Qilin Pills at two dose levels over 60 days improved sperm concentration and motility, and reversed testicular tissue damage. The mechanism involved inhibition of the Bax-caspase-9 apoptosis pathway, suggesting that the formula protects spermatogenesis by reducing programmed cell death in testicular tissue.

Link
4

Preclinical Study: Qilin Pill Exerts Therapeutic Effect on Premature Ovarian Insufficiency Rats via MAPK and PI3K-AKT Pathways (2021)

Li D, Jia Y, Hou Y, et al. Drug Design, Development and Therapy, 2021, 15: 3331-3345.

This preclinical study investigated Qilin Pill's effects on surgically induced premature ovarian insufficiency in rats. After 4 weeks of treatment, QLP improved estrous cycle regularity, increased serum estradiol levels, and increased follicle counts. Network pharmacology analysis and Western blotting confirmed the mechanism involved modulation of MAPK and PI3K-AKT signaling pathways, providing a pharmacological basis for its clinical use in female infertility.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.