Formula Pill (Wan)

Niu Huang Shang Qing Wan

Niu Huang Shang Qing Wan (Cow Bezoar Upper-Heat-Clearing Pill) · 牛黄上清丸

A classic modern pill that relieves intense upper‑body Heat symptoms such as sore throat, red eyes, mouth sores and headache, by clearing internal Fire and dispersing Wind‑Heat.

Origin Modern formula; standardised in the Chinese Pharmacopoeia (first appearing around the 1970s). Not recorded in classical texts. — Modern
Composition 19 herbs
Niu Huang
King
Niu Huang
Ju Hua
Deputy
Ju Hua
Lian Qiao
Deputy
Lian Qiao
Jing Jie
Deputy
Jing Jie
Bai Zhi
Deputy
Bai Zhi
Bo He
Deputy
Bo He
Huang Qin
Assistant
Huang Qin
Huang Lian
Assistant
Huang Lian
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Niu Huang Shang Qing Wan is designed to correct these specific patterns.

Why Niu Huang Shang Qing Wan addresses this pattern

The formula directly drains Toxic‑Heat with Cow Bezoar and the “three yellows,” while guiding Heat out through the stool with Rhubarb. The deputies ensure that the pathogenic Heat in the upper orifices is vented, not simply suppressed.

A practitioner would look for one or more of these signs

Sore Throat

Swollen, painful throat

Mouth Sores

Painful ulcers in the mouth or on the tongue

Gum Pain

Swollen, inflamed gums

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Niu Huang Shang Qing Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acute pharyngitis is seen as Wind‑Heat or Toxic‑Heat invading the throat. The protective Qi fails to ward off the pathogen, leading to local Heat, swelling and pain, often accompanied by dry mouth, fever and headache.

Why Niu Huang Shang Qing Wan Helps

Cow Bezoar, Forsythia, Peppermint and Platycodon directly clear the throat of Heat and toxin, while the strong Fire‑draining herbs rapidly reduce systemic Heat. Rhubarb ensures that Heat is also eliminated through the bowels, freeing the upper body.

Also commonly used for

Chronic Pharyngitis

Used when Wind‑Heat aggravates a chronic sore throat.

Gingivitis

Clears Stomach Fire to lessen gum swelling and bleeding.

Stomatitis

Drains Heart and Stomach Fire that causes mouth and tongue ulcers.

Tension Headache

Relieves headache from up‑flaring Wind‑Heat and Liver Fire.

Otitis Media

Eases tinnitus and ear pain when Wind‑Heat invades the ear.

What This Formula Does

Every TCM formula has a specific set of actions — here's what Niu Huang Shang Qing Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Niu Huang Shang Qing Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Niu Huang Shang Qing Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Niu Huang Shang Qing Wan works at the root level.

When toxic Heat (热毒) accumulates internally and Wind‑Fire (风火) flares upward, it disturbs the clear orifices of the head. The upper body becomes congested with Heat, leading to headache, dizziness, red eyes, tinnitus, sore throat, mouth and tongue sores, and swollen gums. The Heat also damages Body Fluids, causing dry stool. This formula drains the internal Fire, disperses the attacking Wind, cools the Blood, and unblocks the bowels to restore balance.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter — bitter to drain fire and dry dampness, supported by aromatic acrid notes that disperse wind.

Channels Entered

Ingredients

19 herbs

The herbs that make up Niu Huang Shang Qing Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Niu Huang

Niu Huang

Cattle gallstone

Dosage 0.15 - 0.35g
Temperature Cool
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver

Role in Niu Huang Shang Qing Wan

Clears Heat, resolves toxicity, reduces swelling and stops pain; the primary agent targeting the core toxic heat.
Deputies — Assists and enhances the King
Ju Hua

Ju Hua

Chrysanthemum flower

Dosage 6 - 9g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver

Role in Niu Huang Shang Qing Wan

Disperses Wind-Heat from the upper body and brightens the eyes.
Lian Qiao

Lian Qiao

Forsythia fruit

Dosage 9 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine

Role in Niu Huang Shang Qing Wan

Clears Heat and resolves toxicity, especially for the throat and sores, and disperses Wind-Heat.
Jing Jie

Jing Jie

Schizonepeta

Dosage 6 - 9g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver

Role in Niu Huang Shang Qing Wan

Relieves the exterior by dispersing Wind; used here mainly for its ability to vent the pathogen and ease headache and gum pain.
Bai Zhi

Bai Zhi

Dahurian angelica root

Dosage 3 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Stomach, Large Intestine

Role in Niu Huang Shang Qing Wan

Relieves exterior Wind, dries Dampness, and alleviates facial pain and gum swelling.
Bo He

Bo He

Peppermint herb

Dosage 3 - 6g
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver

Role in Niu Huang Shang Qing Wan

Disperses Wind-Heat, benefits the throat, and lifts the constraints of Heat.
Assistants — Supports or moderates other herbs
Huang Qin

Huang Qin

Baical skullcap root

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Niu Huang Shang Qing Wan

Dries Dampness, drains Fire, and detoxifies, particularly clearing Heat from the upper burner.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Niu Huang Shang Qing Wan

Drains Fire and dries Dampness, strongly clearing Heart and Stomach Heat that causes mouth and tongue sores.
Huang Bo

Huang Bo

Phellodendron bark

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Kidneys, Urinary Bladder

Role in Niu Huang Shang Qing Wan

Drains Fire from the lower burner and reduces deficiency Heat; complements the upper-burner herbs.
Da Huang

Da Huang

Rhubarb root and rhizome

Dosage 6 - 12g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium

Role in Niu Huang Shang Qing Wan

Purges Heat and Fire through the bowels, unblocking the stool and draining pathogenic Heat downward.
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)

Role in Niu Huang Shang Qing Wan

Drains Fire, eliminates irritability, cools Blood, and guides Heat out through the urine.
Shi Gao

Shi Gao

Gypsum

Dosage 15 - 30g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Preparation Decocted first for 30 minutes

Role in Niu Huang Shang Qing Wan

Clears Excess Heat from the Yangming channel, especially effective for severe gum pain and facial Heat.
Chi Shao

Chi Shao

Red peony root

Dosage 6 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver

Role in Niu Huang Shang Qing Wan

Cools Blood, invigorates Blood, and reduces swelling and pain from Blood-Heat stagnation.
Di Huang

Di Huang

Rehmannia root

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Kidneys

Role in Niu Huang Shang Qing Wan

Cools Blood, nourishes Yin, and counteracts the Heat damaging Body Fluids.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Niu Huang Shang Qing Wan

Nourishes and moves Blood; prevents the cold herbs from congealing Blood and supports tissue healing.
Chuan Xiong

Chuan Xiong

Sichuan lovage rhizome

Dosage 3 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Niu Huang Shang Qing Wan

Activates Blood and disperses Wind, thus relieving headache; assists the deputies in reaching the upper body.
Bing Pian

Bing Pian

Borneol

Dosage 0.15 - 0.3g
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Spleen, Lungs
Preparation Added in the last 5 minutes of decoction or powdered

Role in Niu Huang Shang Qing Wan

Opens the orifices, disperses stagnation of Fire, and quickly alleviates pain and swelling.
Envoys — Directs the formula to its target
Jie Geng

Jie Geng

Balloon flower root

Dosage 3 - 9g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Niu Huang Shang Qing Wan

Carries the formula's effects upward to the throat and head; guides the medicines to the upper burner.
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Niu Huang Shang Qing Wan

Harmonises the harsh cold actions and moderates the formula; also clears Heat from the throat.

Why This Combination Works

How the herbs in Niu Huang Shang Qing Wan complement each other

Overall strategy

The formula simultaneously clears internal toxic Heat and expels Wind‑Heat from the upper body, guided by the principle of “venting the Fire” (火郁发之).

King herbs

Cow Bezoar (Niu Huang) is cold and aromatic, strongly clearing Heat and resolving toxicity to directly attack the root pathogenic factor.

Deputy herbs

Chrysanthemum (Ju Hua), Forsythia (Lian Qiao), Schizonepeta (Jing Jie), Angelica Dahurica (Bai Zhi) and Peppermint (Bo He) jointly disperse Wind‑Heat from the exterior, relieve the upper orifices, and assist the King herb by “venting the Fire.” This outward dispersal helps break the stagnation of Heat in the head.

Assistant herbs

The group of Scutellaria (Huang Qin), Coptis (Huang Lian), Phellodendron (Huang Bo), Rhubarb (Da Huang) and Gardenia (Zhi Zi) drains Fire from all three burners and purges accumulations through the stool. Gypsum (Shi Gao) specifically clears Yangming channel Heat. Red Peony (Chi Shao), Rehmannia (Di Huang), Angelica Sinensis (Dang Gui) and Chuanxiong (Chuan Xiong) cool and move Blood, preventing the harsh cold from congealing Blood while alleviating pain. Borneol (Bing Pian) opens the orifices and quickly relieves local swelling and pain.

Envoy herbs

Platycodon (Jie Geng) lifts the medicine upward to the throat and head; Licorice (Gan Cao) harmonizes the strong actions and aids in clearing throat Heat.

Notable synergies

The combination of Cow Bezoar and Borneol quickly penetrates the orifices and amplifies the pain‑relieving, anti‑inflammatory effect. The trio of Scutellaria, Coptis and Phellodendron (the “three yellows”) ensures thorough Fire drainage from all burners, while Rhubarb provides an exit for the Heat via the bowels.

How to Prepare

Traditional preparation instructions for Niu Huang Shang Qing Wan

The herbs are finely ground into a powder and combined with honey to form large honey pills (da mi wan), each weighing 6 g. Alternatively, water pills (shui wan) may be prepared. Standard oral administration: 1 pill, 2 times daily.

Common Modifications

How practitioners adapt Niu Huang Shang Qing Wan for specific situations

Added
She Gan

9g, to clear throat Heat and relieve hoarseness

Niu Bang Zi

9g, to dispel Wind-Heat from the throat

She Gan strongly clears the throat and relieves toxicity, while Niu Bang Zi specifically addresses Wind‑Heat attacking the larynx.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Niu Huang Shang Qing Wan should not be used or requires extra caution

Caution

Pregnancy: contains Dahuang (Rhubarb) and Chuanxiong (Sichuan Lovage Root) which may stimulate uterine contractions; use only under strict professional guidance.

Caution

Spleen and Stomach deficiency with loose stools or poor appetite: the cold, bitter nature can further damage the Spleen and Stomach.

Caution

Concurrent use with tonic or warming herbal formulas: the cold-clearing action may counteract the tonifying effects.

Caution

Long-term use: prolonged intake can injure the Spleen and Stomach and deplete Yang Qi.

Avoid

Known hypersensitivity to any ingredient.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Not recommended during pregnancy. This formula contains Dahuang (Rhubarb) and Chuanxiong (Sichuan Lovage Root), which have Blood-moving and downward-draining actions that may pose a risk to the fetus. Some package inserts list it as ‘use with caution’ only under physician supervision, but the safest approach is to avoid it.

Breastfeeding

No specific data on breast milk transfer exists for the herbs in this formula. The cold, bitter nature and the presence of Dahuang may affect the infant’s digestion. Nursing mothers should use only under professional supervision.

Children

Use in children only under professional supervision. Standard adult dosage is not appropriate for children; the dose must be reduced according to age and body weight. Because the formula is strongly Cold and draining, it is not suitable for prolonged use in children, as it can easily damage the developing Spleen and Stomach.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Niu Huang Shang Qing Wan

Well‑documented cautions:

  • Tetracycline antibiotics: Shigao (Gypsum) provides calcium ions that can chelate tetracyclines, significantly reducing antibiotic absorption. Separate dosing by at least 2–3 hours.
  • Aminoglycoside antibiotics: Calcium from Shigao may potentiate the neuromuscular blocking effects of aminoglycosides, increasing the risk of muscle weakness or respiratory depression.
  • Iron, aluminium, or calcium supplements: Metal ions can form insoluble complexes with constituents of the formula, reducing absorption of both the supplement and the herbal medicine.

No well‑documented interactions exist with other drug classes; however, the formula’s cold, draining nature may theoretically antagonise medications that rely on Spleen‑Qi support. Always consult a healthcare provider before concurrent use with prescription medicines.

Usage Guidance

Practical advice for getting the most out of Niu Huang Shang Qing Wan

Best time to take

Take after meals to minimise potential stomach irritation from the cold and bitter ingredients.

Typical duration

Acute use: 3–5 days. If symptoms persist beyond 3 days, stop the formula and seek professional advice. Not intended for long‑term use.

Dietary advice

Avoid spicy, greasy, deep‑fried, and highly pungent foods while taking this formula, as they can aggravate heat. Do not consume alcohol. Avoid concurrent use of tonic or warming herbs/foods. Cold, raw foods should also be limited, since the formula itself is strongly Cold and may overload the Spleen.

Niu Huang Shang Qing Wan originates from Modern formula; standardised in the Chinese Pharmacopoeia (first appearing around the 1970s). Not recorded in classical texts. Modern

Historical Context

How Niu Huang Shang Qing Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Niu Huang Shang Qing Wan is a modern standardised patent formula, not a classical prescription. It was developed during the mid-20th century as a heat‑clearing, wind‑dispersing remedy for common upper‑body ‘fire’ conditions, and it entered the Chinese Pharmacopoeia around the 1970s. Its convenient pill form and reliable efficacy have made it one of the most widely used over‑the‑counter heat‑clearing medicines in China.