Formula Pill (Wan)

Jian Pi Wan

Strengthen the Spleen Pill · 健脾丸

A classical formula for people with weak digestion who also tend to accumulate undigested food. It strengthens the Spleen and Stomach to restore digestive power while simultaneously clearing food stagnation, relieving bloating, poor appetite, and loose stools.

Origin Zhèng Zhì Zhǔn Shéng · Lèi Fāng (《证治准绳·类方》, Standards of Patterns and Treatments: Classified Formulas), Volume 5, by Wáng Kěn Táng (王肯堂) — Míng dynasty, 1602 CE
Composition 13 herbs
Bai Zhu
King
Bai Zhu
Fu Ling
King
Fu Ling
Ren Shen
Deputy
Ren Shen
Shan Yao
Deputy
Shan Yao
Rou Dou Kou
Deputy
Rou Dou Kou
Shan Zha
Deputy
Shan Zha
Shen Qu
Deputy
Shen Qu
Mai Ya
Deputy
Mai Ya
+5
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Jian Pi Wan is designed to correct these specific patterns.

Why Jian Pi Wan addresses this pattern

This is the primary pattern Jian Pi Wan was designed to treat. When Spleen Qi is deficient, the digestive system lacks the power to fully transform food, leading to food accumulating and stagnating in the middle burner. The formula tackles both sides of this problem: Bai Zhu, Fu Ling, Ren Shen, and Gan Cao form the backbone of Si Jun Zi Tang to restore Spleen Qi, while Shan Zha, Shen Qu, and Mai Ya directly resolve the food stagnation. Mu Xiang, Sha Ren, and Chen Pi keep Qi flowing to prevent the tonifying herbs from worsening the stagnation. This balanced approach of "supplementing and reducing together" makes it the representative formula for this combined deficiency-and-excess pattern.

A practitioner would look for one or more of these signs

Poor Appetite

Reduced desire to eat due to weak Spleen failing to signal hunger

Abdominal Bloating

Fullness and distention in the upper abdomen from food stagnation blocking Qi flow

Loose Stools

Poorly formed stools from the Spleen failing to separate clear from turbid

Indigestion

Food sitting heavily in the stomach, difficulty digesting meals

Fatigue

Tiredness and low energy from insufficient Qi production

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Jian Pi Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Spleen Qi Deficiency with Food Stagnation

TCM Interpretation

In TCM, functional dyspepsia is most commonly understood as a failure of the Spleen and Stomach's transportation and transformation functions. When the Spleen Qi is deficient, food cannot be properly broken down and moved through the digestive tract. It lingers in the Stomach, causing feelings of fullness, discomfort, bloating, and loss of appetite. The Stomach's descending function is impaired, so food "sits" rather than moving downward. Over time, the lingering food generates Dampness that further weakens the Spleen, creating a self-reinforcing cycle.

Why Jian Pi Wan Helps

Jian Pi Wan directly mirrors the dual nature of functional dyspepsia. The Ren Shen, Bai Zhu, Fu Ling, and Gan Cao core (Si Jun Zi Tang base) restores the Spleen's Qi and transportation power, addressing the root weakness. Shan Zha, Shen Qu, and Mai Ya actively promote digestion to clear the backlog of stagnant food. Mu Xiang, Sha Ren, and Chen Pi move Qi in the middle burner to relieve the characteristic bloating and fullness. This combined approach both relieves symptoms and rebuilds the digestive capacity to prevent recurrence.

Also commonly used for

Chronic Gastritis

Especially with poor appetite, bloating, and loose stools

Irritable Bowel Syndrome

Diarrhea-predominant type with Spleen deficiency

Indigestion

Chronic poor digestion from weak Spleen function

Malabsorption

Poor nutrient absorption from impaired Spleen transportation

Pediatric Failure to Thrive

Children with chronic food stagnation and weak digestion

Gastroenteritis

Chronic presentations with Spleen deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Jian Pi Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Jian Pi Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Jian Pi Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Jian Pi Wan works at the root level.

This formula addresses a condition where the Spleen and Stomach have become chronically weakened, losing their ability to properly transform and transport food. When the Spleen is deficient, food that is eaten cannot be fully broken down and absorbed. Instead of being converted into Qi and nourishment, food lingers in the digestive tract and accumulates, a state called "food stagnation" (食积, shí jī).

This stagnation creates a vicious cycle: the undigested food blocks the normal flow of Qi through the middle burner, causing a feeling of fullness, bloating, and discomfort in the upper abdomen. Over time, the stagnant food also generates Dampness, which further impairs the Spleen. The Spleen's failure to "raise the clear" (the pure nutrients meant to ascend) results in loose, poorly formed stools. Meanwhile, the combination of Dampness and stagnation can produce mild Heat, which shows on the tongue as a slightly yellow, greasy coating.

The key insight of this pattern is that two problems coexist and reinforce each other: deficiency (the weak Spleen) and excess (the accumulated food and Dampness-Heat). Simply tonifying the Spleen would worsen the stagnation, while aggressively purging the stagnation would further damage the already weak digestion. The formula must therefore address both sides simultaneously, which classical physicians call "supplementing and reducing together" (消补兼施).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet and mildly bitter — sweet to tonify the Spleen, bitter to clear mild Heat and promote digestion, with aromatic notes from Sha Ren and Mu Xiang that awaken the Spleen and move Qi.

Ingredients

13 herbs

The herbs that make up Jian Pi Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 9 - 15g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Preparation Stir-fried (炒白术)

Role in Jian Pi Wan

Strengthens the Spleen, dries Dampness, and restores the digestive system's transporting function. Used at the highest dosage in the formula to address the root Spleen deficiency.
Fu Ling

Fu Ling

Poria

Dosage 9 - 12g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Jian Pi Wan

Strengthens the Spleen and drains Dampness through gentle diuresis, working together with Bai Zhu to firm loose stools and eliminate the pathological Dampness that blocks digestion.
Deputies — Assists and enhances the King
Ren Shen

Ren Shen

Ginseng root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Jian Pi Wan

Powerfully tonifies Qi and strengthens the Spleen, reinforcing the King herbs to restore the Spleen's ability to transform and transport food.
Shan Yao

Shan Yao

Chinese yam

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Jian Pi Wan

Tonifies the Spleen and stops diarrhea with a gentle, nourishing quality, complementing the drying nature of the other tonifying herbs.
Rou Dou Kou

Rou Dou Kou

Nutmeg

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Large Intestine
Preparation Wrapped in flour and baked, then pressed to remove oil (面裹煨热,纸包捶去油)

Role in Jian Pi Wan

Warms the middle burner and astringently binds the intestines to stop diarrhea, addressing the Spleen's inability to consolidate the stools.
Shan Zha

Shan Zha

Hawthorn fruit

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Liver

Role in Jian Pi Wan

Promotes digestion and resolves food stagnation, particularly effective at breaking down meat and greasy food accumulation.
Shen Qu

Shen Qu

Medicated leaven

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach
Preparation Stir-fried (炒神曲)

Role in Jian Pi Wan

Promotes digestion and harmonizes the Stomach, particularly effective at resolving stale and fermented food stagnation.
Mai Ya

Mai Ya

Barley Sprout

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Liver
Preparation Stir-fried (炒麦芽)

Role in Jian Pi Wan

Reduces food stagnation and promotes digestion, especially effective at breaking down starchy and grain-based foods.
Assistants — Supports or moderates other herbs
Mu Xiang

Mu Xiang

Costus root

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, San Jiao (Triple Burner), Gallbladder
Preparation Ground separately (另研)

Role in Jian Pi Wan

Moves Qi and relieves abdominal distention and pain, preventing the tonifying herbs from causing further stagnation in the middle burner.
Sha Ren

Sha Ren

Amomum fruit

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Spleen, Stomach, Kidneys

Role in Jian Pi Wan

Aromatically transforms Dampness, warms the middle, and promotes Qi movement to resolve bloating and restore appetite.
Chen Pi

Chen Pi

Tangerine peel

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen

Role in Jian Pi Wan

Regulates Qi, dries Dampness, and harmonizes the Stomach. Helps prevent the heavy tonifying herbs from creating stagnation.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Preparation Wine-fried (酒炒)

Role in Jian Pi Wan

Clears Heat and dries Dampness, addressing the mild Dampness-Heat generated by prolonged food stagnation. Used in a small dose to avoid damaging the Spleen with excessive cold.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Jian Pi Wan

Tonifies the Spleen and harmonizes all the other herbs in the formula, moderating the properties of the various ingredients to work together smoothly.

Why This Combination Works

How the herbs in Jian Pi Wan complement each other

Overall strategy

Because the patient's core problem is Spleen deficiency complicated by food stagnation and Dampness-Heat, the formula uses a two-pronged approach: strengthening the Spleen as the root treatment while simultaneously promoting digestion and clearing accumulation as the branch treatment. The tonifying herbs are given the largest dosages to prioritize restoring the body's own digestive capacity.

King herbs

Bai Zhu (white atractylodes) and Fu Ling (poria) serve as the King herbs, used at the highest dosages in the formula (75g and 60g respectively in classical proportions). Bai Zhu powerfully strengthens the Spleen and dries Dampness, directly addressing the root deficiency and the pathological moisture that impairs digestion. Fu Ling drains Dampness through gentle diuresis while calming the middle, working together with Bai Zhu to restore the Spleen's transporting function and firm up loose stools.

Deputy herbs

Ren Shen (ginseng) and Gan Cao (licorice root) boost Qi and reinforce the Spleen, amplifying the King herbs' tonifying action. Together with Bai Zhu and Fu Ling they form the backbone of the classic Si Jun Zi Tang (Four Gentlemen Decoction). Shan Yao (Chinese yam) and Rou Dou Kou (nutmeg) further strengthen the Spleen and astringently stop diarrhea. Shan Zha (hawthorn), Shen Qu (medicated leaven), and Mai Ya (barley sprout) form a powerful digestive trio: Shan Zha excels at breaking down meat and greasy food, Mai Ya targets grain-based stagnation, and Shen Qu handles fermented and stale food. Together they resolve the accumulated food that the weak Spleen cannot manage.

Assistant herbs

Mu Xiang (costus root), Sha Ren (cardamom), and Chen Pi (tangerine peel) are aromatic, Qi-moving herbs that serve as reinforcing assistants. They open up the middle burner, relieve the bloating and fullness caused by stagnation, and prevent the heavy tonifying herbs from creating further stagnation. Huang Lian (coptis) acts as a restraining assistant: its cold, bitter nature clears the mild Dampness-Heat that has developed from prolonged food stagnation, while its drying quality also helps resolve Dampness. It is used in a small dose to avoid damaging the Spleen with excessive cold.

Notable synergies

The Bai Zhu and Fu Ling pairing is the backbone for Spleen strengthening and Dampness elimination. The trio of Shan Zha, Shen Qu, and Mai Ya (similar to the classical "Jiao San Xian" combination) covers all categories of food stagnation. Mu Xiang paired with Sha Ren is a classic duo for arousing the Spleen's transportation function and preventing the tonic herbs from creating sluggishness.

How to Prepare

Traditional preparation instructions for Jian Pi Wan

Classical preparation (pill form): All herbs are ground into a fine powder. The powder is then formed into small pills using steamed bread dough (蒸饼) as a binding agent, yielding pills about the size of mung beans. The traditional dose is approximately 50 pills (about 6 g) taken on an empty stomach, twice daily, washed down with aged rice water (陈米汤).

Modern preparation: The formula is commonly available as ready-made pills (honey pills or water pills). A typical dose is 6–9 g per serving, taken with warm water, twice daily. It may also be prepared as a decoction by reducing the original proportions accordingly — in that case, all ingredients are simmered in water for approximately 30–40 minutes, with aromatic herbs like Mu Xiang and Sha Ren added in the final 5 minutes of cooking to preserve their volatile oils.

Common Modifications

How practitioners adapt Jian Pi Wan for specific situations

Added
Che Qian Zi

9 - 15g, to promote urination and drain Dampness

Ze Xie

6 - 9g, to drain Dampness and promote water metabolism

When Dampness is severe, the Spleen is overwhelmed by excess fluid. Che Qian Zi and Ze Xie strengthen the formula's ability to drain Dampness through urination, diverting excess water away from the intestines.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Jian Pi Wan should not be used or requires extra caution

Caution

Excess-type food stagnation without underlying Spleen deficiency. This formula is designed for cases where weak digestion (Spleen deficiency) is the root cause. If the person is otherwise strong and simply overate, a purely digestive formula is more appropriate.

Caution

Yin deficiency with Heat signs, such as dry mouth, scanty tongue coating, hot palms and soles, or a thin rapid pulse. The warming and drying herbs in this formula (Bai Zhu, Rou Dou Kou, Sha Ren) can further deplete Yin fluids.

Avoid

Acute gastroenteritis or infectious diarrhea with fever and watery stools. This formula is intended for chronic Spleen deficiency patterns, not acute infections.

Caution

Active external pathogen invasion (such as a cold or flu with fever and chills). Tonic herbs like Ren Shen can trap the pathogen inside the body, worsening the condition. The external illness should be resolved first.

Caution

Severe Damp-Heat in the Stomach and Intestines, indicated by foul-smelling loose stools, burning sensation in the anus, thick yellow greasy tongue coating, and strong thirst. Although the formula contains a small amount of Huang Lian for mild Heat, it is not sufficient for pronounced Damp-Heat conditions.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe during pregnancy at standard doses, as the formula contains no strongly Blood-moving, downward-draining, or uterine-stimulating herbs. However, some caution is advised: Zhi Shi (枳实), which appears in the modern patent medicine version, has a descending and breaking nature that some classical texts caution against in pregnancy. Women who are pregnant should consult a qualified practitioner before use. The classical version (from Zheng Zhi Zhun Sheng) does not contain Zhi Shi and is considered gentler.

Breastfeeding

Jian Pi Wan is generally considered compatible with breastfeeding. The herbs in the formula are predominantly mild tonics and digestive aids without known concerns for transfer of harmful substances through breast milk. The formula may actually support milk production indirectly by strengthening Spleen Qi, which TCM considers the source of Qi and Blood generation. Nonetheless, as the official product labeling advises that breastfeeding women should use this medicine under practitioner guidance, it is prudent to consult a qualified healthcare provider before use.

Children

Jian Pi Wan is considered suitable for children, particularly for chronic poor appetite, failure to thrive, and loose stools due to Spleen deficiency with food stagnation. A dedicated pediatric formulation called Xiao Er Jian Pi Wan (小儿健脾丸) exists with slightly different composition and appropriate dosing. For the standard adult formula, children's doses should be adjusted by age and body weight under practitioner guidance. A common approach is to give approximately one-third to one-half of the adult dose for children aged 3–7, and two-thirds for children aged 7–14. The OTC product labeling states that children should use this medicine only under adult supervision and practitioner direction.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Jian Pi Wan

Gan Cao (Licorice root) in this formula contains glycyrrhizin, which can cause potassium loss and sodium retention with prolonged use. This may interact with:

  • Diuretics (thiazides, loop diuretics): increased risk of hypokalemia when combined.
  • Cardiac glycosides (digoxin): licorice-induced hypokalemia may increase digoxin toxicity.
  • Corticosteroids: may enhance potassium-depleting and sodium-retaining effects.
  • Antihypertensives: licorice may counteract blood-pressure-lowering effects.

Ren Shen (Ginseng) may interact with warfarin (potentially reducing anticoagulant effect) and MAO inhibitors. It may also affect blood glucose levels, warranting caution with insulin or oral hypoglycemics.

Huang Lian (Coptis) contains berberine, which has documented interactions with cyclosporine (increased blood levels) and may potentiate the effects of oral hypoglycemic agents and metformin.

The formula should not be taken concurrently with preparations containing Li Lu (Veratrum), Wu Ling Zhi, or Zao Jia (Gleditsia), per classical incompatibility rules related to Ren Shen.

Usage Guidance

Practical advice for getting the most out of Jian Pi Wan

Best time to take

On an empty stomach, 30–60 minutes before meals, twice daily (morning and evening). This allows the digestive and tonifying herbs to act before food arrives.

Typical duration

Typically taken for 2–4 weeks as a patent medicine, with reassessment by a practitioner. Chronic Spleen deficiency patterns may require 4–8 weeks or longer.

Dietary advice

Avoid cold and raw foods (salads, iced drinks, raw fruit in excess), greasy or fried foods, and dairy products, as these burden an already weak Spleen and generate Dampness. Avoid overeating or eating late at night. Favor warm, cooked, easily digestible foods: rice porridge (congee), cooked root vegetables, soups, and well-cooked grains. Small, regular meals are preferable to large ones. Mildly warming spices like ginger, cardamom, and small amounts of cinnamon in cooking can complement the formula's action. Avoid strong tea and raw radish (luobo) while taking this formula, as these may reduce its effectiveness.

Jian Pi Wan originates from Zhèng Zhì Zhǔn Shéng · Lèi Fāng (《证治准绳·类方》, Standards of Patterns and Treatments: Classified Formulas), Volume 5, by Wáng Kěn Táng (王肯堂) Míng dynasty, 1602 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Jian Pi Wan and its clinical use

From the original source text 《证治准绳·类方》(Zhèng Zhì Zhǔn Shéng · Lèi Fāng):

The formula verse (方歌) summarizes its composition and strategy: "健脾参术苓草陈,肉蔻香连合砂仁,楂肉山药曲麦炒,消补兼施此方寻。" ("Jian Pi uses Ren Shen, Bai Zhu, Fu Ling, Gan Cao, and Chen Pi; Rou Dou Kou, Mu Xiang, Huang Lian paired with Sha Ren; Shan Zha, Shan Yao, Shen Qu, and stir-fried Mai Ya — seek this formula for combined tonification and digestive action.")

Pathomechanism commentary from classical formula analysis:

"脾虚不运,以致食积内停,津气阻滞,治宜着重健运脾气,恢复功能,消食仅居其次。" ("When the Spleen is deficient and fails to transport, food accumulates internally and fluids and Qi become obstructed. Treatment should focus on strengthening and restoring Spleen function, with digesting food stagnation as a secondary objective.")

Historical Context

How Jian Pi Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Jian Pi Wan first appeared in the Zhèng Zhì Zhǔn Shéng · Lèi Fāng (《证治准绳·类方》, "Standards of Patterns and Treatments: Classified Formulas"), Volume 5, compiled by the Ming dynasty physician Wáng Kěn Táng (王肯堂, 1549–1613). Wang spent 11 years compiling this monumental 44-volume medical encyclopedia, which became one of the most widely circulated medical texts of the 17th century. His approach was notably even-handed — he did not favor any single school of thought regarding warming versus cooling or tonifying versus draining strategies.

The formula's design reflects the core principle of "消补兼施,补重于消" — using both tonification and digestion together, with tonification as the primary strategy. It builds upon the foundation of the classic Si Jun Zi Tang (Four Gentlemen Decoction), adding digestive and Qi-regulating herbs. Later generations adapted the formula into various patent medicine versions. The modern OTC product "Jian Pi Wan" uses a simplified 6-herb version (with Dang Shen replacing Ren Shen, and adding Zhi Shi), while the original classical version contained 13 herbs. The related "Ren Shen Jian Pi Wan" is yet another expanded modification with additional herbs for broader application. These distinctions are clinically important and should not be confused.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Jian Pi Wan

1

Efficacy of Jianpi Liqi therapy for functional dyspepsia: A meta-analysis of randomized, positive medicine-controlled trials (2019)

Tian JY, Kou DQ, et al. Medicine. 2019; 98(44):e17849.

This meta-analysis pooled 15 randomized controlled trials with 1,451 participants to assess whether Jianpi Liqi (Spleen-strengthening and Qi-regulating) herbal therapy could treat functional dyspepsia. The analysis found that Jianpi Liqi therapy was significantly more effective than conventional drugs like domperidone, omeprazole, and mosapride (OR 0.34, 95% CI 0.26–0.45, P < 0.00001). The authors noted the need for more large-scale, rigorously designed trials to confirm these findings.

PubMed
2

The efficacy of Jianpi Yiqi therapy for chronic atrophic gastritis: A systematic review and meta-analysis (2017)

Li G, et al. PLOS One. 2017; 12(7):e0181906.

This systematic review analyzed 13 RCTs involving 1,119 patients with chronic atrophic gastritis. Jianpi Yiqi (Spleen-strengthening and Qi-supplementing) therapy showed significantly better clinical outcomes than Western medicine alone, and improved symptoms including stomach pain, distention, belching, and fatigue. However, the evidence quality was rated 'very low' by GRADE criteria due to high risk of bias and small sample sizes in the included studies.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.