Di Yu San

Sanguisorba Powder · 地榆散

A classical powder formula used to cool Blood-Heat, regulate Qi flow in the intestines, and stop bleeding. It is primarily used for hemorrhoidal pain and bleeding caused by Damp-Heat accumulating in the lower body, and can also be applied to intestinal bleeding with bright red blood.

Origin Tai Ping Sheng Hui Fang (太平圣惠方) — Song dynasty, 992 CE
Composition 7 herbs
Di Yu
King
Di Yu
Huang Qin
Deputy
Huang Qin
Zhi Ke
Deputy
Zhi Ke
Bing Lang
Deputy
Bing Lang
Huang Qi
Assistant
Huang Qi
Dang Gui
Assistant
Dang Gui
Chi Shao
Assistant
Chi Shao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Di Yu San is designed to correct these specific patterns.

Why Di Yu San addresses this pattern

Damp-Heat accumulating in the Large Intestine is the primary pattern this formula targets. When Damp-Heat lodges in the lower intestines, it damages the blood vessels in the anorectal area, causing hemorrhoidal swelling and bleeding. Di Yu directly cools the Blood-Heat in the Large Intestine channel, while Huang Qin clears the Heat and dries the Dampness that underlies the condition. Zhi Ke and Bing Lang address the Qi stagnation that Damp-Heat causes in the intestines, relieving distension and straining. Chi Shao and Dang Gui prevent Blood stasis while promoting tissue healing, and Huang Qi supports the body's capacity to hold Blood within the vessels.

A practitioner would look for one or more of these signs

Rectal Bleeding

Bright red blood with bowel movements

Hemorrhoids

Swollen, painful hemorrhoids

Constipation

Difficult bowel movements with straining

Abdominal Distention

Lower abdominal bloating and bearing-down sensation

Bitter Taste

Bitter taste in the mouth with thirst

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Di Yu San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Damp-Heat in the Large Intestine Blood Heat

TCM Interpretation

TCM views hemorrhoids as arising primarily from Damp-Heat pouring downward into the Large Intestine, where it congests the local blood network and causes the tissue to swell, protrude, and bleed. Contributing factors include excessive consumption of rich, spicy, or alcoholic foods, prolonged sitting, emotional stress generating internal Heat, and constitutional weakness of the Spleen's ability to hold Blood in the vessels. The Damp component causes swelling and a heavy, bearing-down feeling, while the Heat component drives the bleeding and burning pain.

Why Di Yu San Helps

Di Yu San targets hemorrhoids through several complementary mechanisms. Di Yu, the chief herb, directly cools Blood-Heat in the Large Intestine channel and uses its astringent quality to constrict bleeding vessels. Huang Qin clears the underlying Damp-Heat that causes the hemorrhoidal inflammation. Zhi Ke and Bing Lang relax the intestines and promote smooth Qi flow, relieving the straining and distension that worsen hemorrhoids. Huang Qi supports tissue healing, while Dang Gui and Chi Shao ensure blood circulation remains healthy so that stopping the bleeding does not lead to further congestion. A clinical study found that adding Di Yu San to standard post-surgical care for mixed hemorrhoid patients achieved a 100% effectiveness rate compared to 86.67% with standard care alone.

Also commonly used for

Dysentery

Bacterial dysentery with bloody stool

Colitis

Inflammatory bowel conditions with bloody diarrhea

Gastrointestinal Bleeding

Upper or lower GI bleeding associated with Heat patterns

Heavy Menstrual Bleeding

Excessive menstrual bleeding due to Blood-Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Di Yu San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Di Yu San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Di Yu San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Di Yu San works at the root level.

This formula addresses a condition where Damp-Heat accumulates in the Large Intestine and damages the blood vessels in the anorectal area. In TCM understanding, poor diet (excess spicy, greasy, or alcoholic foods), prolonged sitting, or constitutional tendencies can cause Heat and Dampness to brew in the lower body. When this Damp-Heat pours downward into the intestines, it injures the local blood network, forcing Blood out of the vessels. This produces hemorrhoidal bleeding with bright red blood.

At the same time, the Heat congests Qi movement in the intestines, leading to a feeling of distension, bearing-down pressure, and straining. The combination of Blood-Heat forcing blood out of the vessels and Qi stagnation causing swelling and pain creates the characteristic picture of hot, painful, bleeding hemorrhoids. Because the bleeding is driven by Heat rather than cold or deficiency, the blood is typically fresh and red, and is often accompanied by signs like a bitter taste in the mouth, a red tongue with yellow greasy coating, and a slippery rapid pulse.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and slightly sour, with mild astringency. The bitter taste clears Heat and dries Dampness, while the sour-astringent quality helps contain and stop bleeding.

Ingredients

7 herbs

The herbs that make up Di Yu San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Di Yu

Di Yu

Garden Burnet Root

Dosage 9 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Large Intestine, Stomach

Role in Di Yu San

The chief herb of this formula. Di Yu enters the Large Intestine channel, where it cools Blood-Heat and stops bleeding through its bitter, sour, and astringent nature. It directly targets the hemorrhoidal bleeding that is the formula's primary indication.
Deputies — Assists and enhances the King
Huang Qin

Huang Qin

Baical skullcap root

Dosage 9 - 15g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Di Yu San

Clears Heat and dries Dampness, reinforcing Di Yu's ability to cool Blood-Heat in the Large Intestine. Its bitter-cold nature helps eliminate the underlying Damp-Heat that drives hemorrhoidal inflammation and bleeding.
Zhi Ke

Zhi Ke

Bitter orange fruit

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine, Lungs

Role in Di Yu San

Promotes the movement of Qi and relieves distension in the intestines. By opening up Qi stagnation in the lower abdomen, it addresses the bloating, bearing-down sensations, and constipation that accompany hemorrhoids.
Bing Lang

Bing Lang

Areca seed (Betel nut)

Dosage 9 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Stomach, Large Intestine

Role in Di Yu San

Works alongside Zhi Ke to move Qi downward and relax the intestines. It helps relieve the sensation of heaviness and straining at stool that is characteristic of hemorrhoidal disease.
Assistants — Supports or moderates other herbs
Huang Qi

Huang Qi

Astragalus root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Di Yu San

Tonifies Qi and supports the body's ability to hold Blood in the vessels. Combined with Dang Gui, it promotes tissue healing and the generation of new flesh, helping hemorrhoidal wounds repair more quickly.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Di Yu San

Nourishes and invigorates Blood, preventing the formula's Blood-cooling herbs from causing Blood stasis. It also supports tissue regeneration and helps alleviate pain from hemorrhoidal swelling.
Chi Shao

Chi Shao

Red peony root

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver

Role in Di Yu San

Clears Heat from the Blood level and disperses Blood stasis. It works with Dang Gui to ensure that stopping bleeding does not lead to stagnant Blood pooling locally, and it helps reduce swelling and pain in the hemorrhoidal tissue.

Why This Combination Works

How the herbs in Di Yu San complement each other

Overall strategy

The formula simultaneously cools Blood-Heat to stop bleeding, moves Qi to relieve intestinal congestion, and invigorates Blood to prevent stasis, all while supporting tissue repair. This multi-angle approach ensures that bleeding is stopped without trapping old Blood locally, and that the underlying Damp-Heat driving the condition is addressed rather than just the symptom of bleeding.

King herbs

Di Yu (Sanguisorba root) is the chief herb. It enters the Large Intestine channel directly and is considered one of the best herbs for cooling Blood-Heat in the lower body. Its bitter and cold nature clears the Heat that forces Blood out of the vessels, while its sour and astringent quality helps constrict the bleeding vessels and stop hemorrhage.

Deputy herbs

Huang Qin clears Heat and dries Dampness, reinforcing Di Yu's Blood-cooling action and tackling the Damp-Heat at its root. Zhi Ke and Bing Lang together promote Qi movement in the intestines, relieving the distension, bearing-down sensation, and straining that accompany hemorrhoids. By keeping Qi flowing smoothly, they prevent the formula from being purely astringent and stagnating.

Assistant herbs

Huang Qi (reinforcing type) tonifies Qi and supports the body's ability to contain Blood in the vessels, while also promoting tissue healing. Dang Gui and Chi Shao work as a pair: Dang Gui nourishes and moves Blood to prevent the cooling herbs from causing stasis, while Chi Shao clears residual Heat from the Blood level and disperses existing stagnation. Together they ensure the formula stops bleeding without leaving behind pooled Blood that could worsen swelling.

Notable synergies

The Di Yu and Huang Qin pairing creates a powerful dual action of cooling Blood and drying Dampness in the Large Intestine. The Zhi Ke and Bing Lang pair ensures smooth Qi flow to counterbalance the astringent tendency of the hemostatic herbs. The Huang Qi and Dang Gui combination, a classic pairing for generating flesh and healing wounds, adds a restorative dimension that promotes post-bleeding tissue recovery.

How to Prepare

Traditional preparation instructions for Di Yu San

Classical method (powder form): All seven herbs are ground together into a coarse powder (散). For each dose, take 12 grams of the powder and decoct it in approximately 300 ml of water. Bring to a boil, then simmer until the liquid is reduced by about one-third. Strain and drink warm.

Modern decoction method: The formula can also be prepared as a standard decoction (汤剂) using raw herb slices. Use conventional clinical dosages for each herb (typically 6–10g each). Soak the herbs in cold water for 20–30 minutes, then bring to a boil and simmer for 20–25 minutes. Strain and divide the liquid into two servings. A second decoction can be made from the same herbs.

No special preparation order is required for any of the herbs. The formula is taken without regard to meals, though an empty stomach may improve absorption.

Common Modifications

How practitioners adapt Di Yu San for specific situations

Added
Hou Pu

6 - 9g, to strongly move Qi and relieve distension

Da Fu Pi

9 - 12g, to promote Qi movement and reduce abdominal fullness

Mu Xiang

3 - 6g, to regulate Qi flow in the intestines

When Qi stagnation in the intestines is pronounced, producing severe bloating and a heavy bearing-down sensation, additional Qi-moving herbs are needed beyond what Zhi Ke and Bing Lang alone can address.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Di Yu San should not be used or requires extra caution

Avoid

Bleeding caused by Spleen-Qi deficiency and Cold (deficiency-Cold type bleeding) rather than Blood-Heat. Di Yu San is designed for Heat in the Blood causing hemorrhoidal and intestinal bleeding. Using it for Cold-type bleeding with pale blood, cold limbs, and a pale tongue would be inappropriate, as the formula's cool nature could worsen the condition.

Avoid

Pregnancy. The formula contains Chi Shao (Red Peony Root), which moves Blood and disperses stasis, and Bing Lang (Areca Seed), which has downward-draining properties. These herbs carry a risk of stimulating uterine contractions or promoting bleeding.

Caution

Bleeding with significant Blood stasis (dark purple clots, fixed stabbing pain) that requires stronger Blood-moving treatment. While Di Yu San has mild Blood-moving action from Chi Shao and Dang Gui, it is primarily a cooling and stopping formula and may not be sufficient for severe stasis.

Caution

Patients with weak digestion, loose stools, or significant Spleen-Yang deficiency. The cold and bitter herbs Di Yu and Huang Qin can further impair Spleen function and worsen diarrhea in constitutionally cold patients.

Caution

Concurrent use of anticoagulant or antiplatelet medications without medical supervision. The formula's hemostatic action may interact unpredictably with blood-thinning drugs.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Chi Shao (Red Peony Root), which activates Blood circulation and disperses stasis, carrying a theoretical risk of stimulating uterine contractions. Bing Lang (Areca Seed) has downward-draining and Qi-moving properties that are generally cautioned against during pregnancy. Additionally, the strong Blood-cooling action of Di Yu and Huang Qin may not be appropriate for the physiological state of pregnancy. Pregnant women experiencing hemorrhoidal bleeding should seek an alternative formula specifically adapted for use during pregnancy.

Breastfeeding

Use with caution during breastfeeding. Bing Lang (Areca Seed) contains arecoline, a parasympathomimetic alkaloid that may theoretically pass into breast milk. While the amounts used in a typical decoction are small, it is prudent to use this formula only when clearly indicated and under professional supervision. The other herbs in the formula (Di Yu, Huang Qin, Chi Shao, Dang Gui, Huang Qi, Zhi Ke) are not generally considered problematic during breastfeeding in standard dosages, though the formula's overall cool nature could potentially affect milk production in some individuals. Short-term use for acute hemorrhoidal bleeding is more appropriate than prolonged administration.

Children

Di Yu San can be used in children, particularly for bloody dysentery or intestinal bleeding due to Heat. Classical texts from the Tai Ping Hui Min He Ji Ju Fang explicitly address pediatric dosing for a related Di Yu San version, noting that children aged three may take half the adult dose, with further reductions based on age. For the standard version, reduce all herb dosages to one-third to one-half of adult amounts for children over six years old, and to one-quarter for children aged three to six. This formula is generally not suitable for infants under two years old without close specialist supervision due to its cooling and Qi-moving properties. Bing Lang (Areca Seed) should be used cautiously in young children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Di Yu San

Anticoagulant and antiplatelet medications: Di Yu San is designed to stop bleeding by cooling Blood and promoting hemostasis. Its hemostatic action (primarily from Di Yu, which contains tannins that promote platelet aggregation) may counteract the effects of warfarin, heparin, aspirin, or clopidogrel. Conversely, Chi Shao and Dang Gui have mild Blood-activating effects that could theoretically potentiate anticoagulant effects. The net interaction is unpredictable, and concurrent use should be monitored.

Antihypertensive medications: Huang Qin (Scutellaria root) has documented hypotensive properties and may enhance the blood-pressure-lowering effects of antihypertensive drugs.

Cholinergic drugs: Bing Lang (Areca Seed) contains arecoline, a muscarinic agonist. It may potentiate the effects of cholinergic medications or parasympathomimetics, and could theoretically antagonize anticholinergic drugs.

Usage Guidance

Practical advice for getting the most out of Di Yu San

Best time to take

Twice daily, on an empty stomach or between meals, for optimal absorption.

Typical duration

Acute use: 3–7 days for active hemorrhoidal bleeding; may be extended to 2 weeks if symptoms persist, then reassessed.

Dietary advice

Avoid spicy, fried, and greasy foods, which generate Heat and Dampness in the Large Intestine and can worsen hemorrhoidal bleeding. Limit alcohol consumption, as alcohol produces Damp-Heat and promotes bleeding. Avoid excessively cold or raw foods, which may impair digestion in patients who already have weakened Spleen Qi. Favor bland, easily digestible foods such as congee, steamed vegetables, and cooked grains. Adequate dietary fiber from cooked vegetables and whole grains can help regulate bowel movements and reduce straining, which aggravates hemorrhoids. Cooling foods like mung beans, lotus root, and winter melon can support the formula's Heat-clearing action.

Di Yu San originates from Tai Ping Sheng Hui Fang (太平圣惠方) Song dynasty, 992 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Di Yu San and its clinical use

From the formula analysis (方解):

「方中地榆清热解毒,凉血止血,尤善清大肠之湿热,凉大肠之血。」
"Di Yu in this formula clears Heat and resolves toxins, cools the Blood and stops bleeding, and is especially skilled at clearing Damp-Heat from the Large Intestine and cooling the Blood of the Large Intestine."

Classical indications as recorded in the Tai Ping Sheng Hui Fang (太平圣惠方):

「泻血肠风,痔疮下血。」
"Treats intestinal wind with bloody stool, and hemorrhoidal bleeding."

From the Ben Cao Xin Bian (本草新编) on the chief herb Di Yu:

「但治热而不治寒,虚寒之人,不可轻用地榆凉血之品也。」
"It only treats Heat, not Cold. For those with deficiency-Cold, one must not lightly use Di Yu, a Blood-cooling substance."

Historical Context

How Di Yu San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Di Yu San is one of many formulas bearing this name across classical Chinese medical literature. The version most widely referenced in modern clinical practice, composed of Di Yu, Huang Qi, Zhi Ke, Bing Lang, Huang Qin, Chi Shao, and Dang Gui, originates from the Tai Ping Sheng Hui Fang (太平圣惠方), compiled in 992 CE during the early Song dynasty under imperial decree. This massive formulary, containing nearly 17,000 prescriptions across 100 volumes, was one of the most ambitious medical compilations in Chinese history.

A closely related but expanded version appears in the Ren Zhai Zhi Zhi Fang Lun (仁斋直指方论) by Yang Shiying (杨士瀛, courtesy name Dengfu 登父, literary name Renzhai 仁斋), a prominent Southern Song dynasty physician from Fujian. Yang's version adds Chuan Xiong, Huai Hua, Qiang Huo, Bai Lian, Feng Fang, and Gan Cao, broadening its scope to treat hemorrhoidal swelling and pain more comprehensively. Other versions of Di Yu San appear in the Sheng Ji Zong Lu (圣济总录) for bloody dysentery, in the Wai Tai Mi Yao (外台秘要) for traumatic bleeding, and in the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方) for chronic dysentery with a very different composition including Ying Su Ke (Poppy Husk). The diversity of formulas sharing this name reflects how central Di Yu was as a hemostatic herb throughout Chinese medical history.