Dang Gui Jian Zhong Tang

Tangkuei Decoction to Construct the Middle · 当归建中汤

Also known as: Nei Bu Dang Gui Jian Zhong Tang (内补当归建中汤, Internally Supplementing Tangkuei Center-Fortifying Decoction)

A warming, blood-nourishing formula traditionally used for abdominal pain caused by Blood deficiency and Cold in the middle. Originally developed for postpartum recovery, it helps relieve cramping pain in the lower abdomen and back, supports weakened digestion, and rebuilds strength after blood loss or exhaustion.

Origin Qian Jin Yi Fang (千金翼方, Supplement to the Thousand Gold Prescriptions) by Sun Simiao; originally appeared as Nei Bu Dang Gui Jian Zhong Tang in the Bei Ji Qian Jin Yao Fang (备急千金要方). — Tang dynasty, c. 682 CE
Composition 6 herbs
Dang Gui
King
Dang Gui
Bai Shao
King
Bai Shao
Gui Zhi
Deputy
Gui Zhi
Sheng Jiang
Assistant
Sheng Jiang
Da Zao
Assistant
Da Zao
Zh
Envoy
Zhi Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dang Gui Jian Zhong Tang is designed to correct these specific patterns.

Why Dang Gui Jian Zhong Tang addresses this pattern

This is the primary pattern for which Dang Gui Jian Zhong Tang was designed. When Blood is deficient and the middle is cold, the channels and muscles lack nourishment and warmth, leading to cramping abdominal pain that is relieved by warmth and pressure. Dang Gui directly tonifies and moves Blood, while Bai Shao nourishes Liver Blood and relaxes spasms. Gui Zhi warms the channels and promotes Blood circulation, and the supporting herbs (Sheng Jiang, Da Zao, Zhi Gan Cao) strengthen the Spleen to restore the body's ability to generate new Blood. The formula addresses both the root (Blood deficiency) and the branch (Cold-induced cramping pain).

A practitioner would look for one or more of these signs

Abdominal Pain

Cramping or pulling pain in the lower abdomen, relieved by warmth and pressure

Low Back Pain

Pain radiating from lower abdomen to lower back

Pale Complexion

Sallow or pale face without lustre

Fatigue

Exhaustion and physical weakness

Shortness Of Breath

Shortness of breath on mild exertion

Poor Appetite

Reduced appetite and inability to eat

Spontaneous Sweating

Spontaneous sweating due to Qi and Blood deficiency

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Dang Gui Jian Zhong Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Deficiency with Cold Liver Blood Deficiency

TCM Interpretation

In TCM, painful periods can arise from several different root causes. This formula specifically targets the type where the person has an underlying Blood deficiency and Cold in the lower abdomen. The uterus (called the 'Palace of Blood') depends on adequate, warm Blood to fill and empty smoothly each cycle. When Blood is insufficient and Cold constricts the channels, the uterus cramps painfully. The Liver, which governs the smooth flow of Blood to the uterus, becomes tense when it lacks Blood, worsening the spasms. The Spleen, weakened by Cold, fails to produce enough new Blood to replenish what is lost each month.

Why Dang Gui Jian Zhong Tang Helps

Dang Gui directly nourishes and moves Blood in the uterus, while Bai Shao relaxes the uterine spasm and nourishes Liver Blood. Gui Zhi warms the channels of the lower abdomen to dispel Cold and promote Blood circulation, addressing the Cold that causes constriction. The Bai Shao and Zhi Gan Cao pair is a classical antispasmodic combination that targets the cramping pain itself. Modern research has identified that this formula's mechanism in dysmenorrhea involves modulation of arachidonic acid metabolism, glycerophospholipid metabolism, and steroid hormone synthesis, with active constituents including ferulic acid (from Dang Gui) and cinnamic acid (from Gui Zhi).

Also commonly used for

Abdominal Pain

Chronic abdominal pain due to deficiency and Cold

Chronic Gastritis

Gastritis with epigastric pain relieved by warmth

Peptic Ulcer

Gastric or duodenal ulcers with deficiency-Cold pattern

Low Blood Pressure

Chronic hypotension with fatigue and dizziness

Low Back Pain

Lower back pain associated with Blood deficiency

Sciatica

Sciatic pain in constitutionally weak, blood-deficient individuals

What This Formula Does

Every TCM formula has a specific set of actions — here's what Dang Gui Jian Zhong Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Dang Gui Jian Zhong Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Dang Gui Jian Zhong Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Dang Gui Jian Zhong Tang works at the root level.

This formula addresses a condition where Blood deficiency and Cold in the middle combine to cause pain and exhaustion, most classically seen after childbirth. During delivery, significant blood is lost. When the body's Blood becomes insufficient, the channels and organs lose their nourishment, and the muscles and sinews of the abdomen cannot be properly moistened and relaxed. This leads to cramping, spasmodic pain in the lower belly that can radiate to the lower back.

At the same time, the Spleen and Stomach (the digestive centre) are weakened. The Spleen is responsible for generating Qi and Blood from food. When it is cold and feeble, it cannot produce enough of either, creating a vicious cycle: Blood deficiency leads to poor nourishment of the middle, and a weak middle cannot generate new Blood. The Liver, which stores Blood and governs the smooth flow of Qi, also suffers. When the Liver lacks Blood, it becomes tense and 'rigid,' losing its ability to keep things flowing smoothly. The Liver then overacts on the already-weak Spleen (a pattern called 'Wood overacting on Earth'), intensifying the cramping pain.

The result is a person who is exhausted, thin, pale, short of breath, and suffering from recurrent abdominal pain that feels better with warmth and pressure. They may have poor appetite and spontaneous sweating. Though the original text focuses on postpartum women, this same mechanism of Blood deficiency with middle Cold can appear in anyone after significant blood loss, chronic illness, or prolonged physical exhaustion.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and mildly pungent — sweet to tonify the Middle Jiao, nourish Blood, and ease cramping; pungent to gently warm and promote circulation.

Ingredients

6 herbs

The herbs that make up Dang Gui Jian Zhong Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Dang Gui Jian Zhong Tang

The defining herb of this formula. Tonifies and invigorates Blood, nourishes the Liver, and alleviates pain due to Blood deficiency and stasis. It gives the formula its Blood-nourishing focus and directly addresses the root cause of postpartum or Blood-deficiency abdominal pain.
Bai Shao

Bai Shao

White peony root

Dosage 12 - 18g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Dang Gui Jian Zhong Tang

Used at the largest dose in the formula. Nourishes Liver Blood, softens the Liver to prevent it from overacting on the Spleen, and relaxes spasming muscles and sinews to relieve abdominal cramping. Pairs with Gan Cao for powerful antispasmodic action.
Deputy — Assists and enhances the King
Gui Zhi

Gui Zhi

Cinnamon twig

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder

Role in Dang Gui Jian Zhong Tang

Warms the channels and promotes the movement of Yang Qi. Supports the warming function of the Middle Jiao and works with Bai Shao to harmonize the Ying (nutritive) and Wei (defensive) levels, addressing spontaneous sweating.
Assistants — Supports or moderates other herbs
Sheng Jiang

Sheng Jiang

Fresh ginger rhizome

Dosage 6 - 9g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach

Role in Dang Gui Jian Zhong Tang

Warms the Stomach and aids digestion. Helps restore appetite and supports the upward and outward movement of Qi from the middle. Assists Gui Zhi in warming and dispersing Cold.
Da Zao

Da Zao

Jujube fruit

Dosage 4 - 12 pieces
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart

Role in Dang Gui Jian Zhong Tang

Nourishes the Spleen and Blood, generates fluids, and moderates the other herbs. Supports the middle as the source of Qi and Blood production.
Envoy — Directs the formula to its target
Zh

Zhi Gan Cao

Dosage 3 - 6g

Role in Dang Gui Jian Zhong Tang

Harmonizes all the herbs. Pairs with Bai Shao in the classical antispasmodic combination to relieve abdominal cramping. Tonifies Spleen Qi and supports the middle.

Why This Combination Works

How the herbs in Dang Gui Jian Zhong Tang complement each other

Overall strategy

The formula simultaneously warms the middle to restore digestive function and nourishes Blood to relieve the spasmodic pain caused by Blood deficiency. It builds on the framework of Xiao Jian Zhong Tang (Minor Center-Fortifying Decoction) but shifts the emphasis from pure middle-warming toward Blood nourishment and pain relief.

King herbs

Dang Gui (Angelica sinensis root, 12g) is the defining addition that gives this formula its name and focus. It tonifies and invigorates Blood, nourishes the Liver, and helps move stagnant Blood that may be contributing to pain. Bai Shao (white peony root, 18g) is used at a large dose to soften the Liver, nourish Liver Blood, and relax spasming muscles and sinews in the abdomen. Together, Dang Gui and Bai Shao form the core Blood-nourishing and pain-relieving pair.

Deputy herbs

Gui Zhi (cinnamon twig, 9g) warms the channels and promotes the movement of Qi and Blood. It supports the Yang aspect of the middle, helping the Spleen regain its warming, transforming function. It also works with Bai Shao to harmonize the Ying (nutritive) and Wei (defensive) levels, addressing spontaneous sweating.

Assistant herbs

Sheng Jiang (fresh ginger, 9g) warms the Stomach and aids digestion, helping restore the appetite that is often lost in this condition (reinforcing assistant). Da Zao (jujube, 6-12 pieces) nourishes the Spleen and Blood, and helps generate fluids (reinforcing assistant). Both also work alongside Gui Zhi to promote the harmonious circulation of Ying and Wei Qi.

Envoy herbs

Zhi Gan Cao (honey-prepared licorice, 6g) harmonizes all the herbs in the formula. It pairs with Bai Shao in the classical 'Shao Yao Gan Cao' combination, where sweet and sour flavours together powerfully relax spasms and relieve cramping pain. It also supports the Spleen Qi directly.

Notable synergies

The Bai Shao and Zhi Gan Cao pairing (Shao Yao Gan Cao Tang) is one of the most famous antispasmodic combinations in Chinese medicine. The Dang Gui and Bai Shao pairing nourishes Blood from both the tonifying and astringing angles, while Gui Zhi and Bai Shao together harmonize Ying and Wei. The overall formula blends pungent-sweet flavours (which generate Yang) with sour-sweet flavours (which nourish Yin), gently restoring the balance of both.

How to Prepare

Traditional preparation instructions for Dang Gui Jian Zhong Tang

Classical Decoction Method

Combine Dang Gui (当归, 12g), Gui Xin/Gui Zhi (桂心, 9g), Bai Shao (白芍, 18g), Sheng Jiang (生姜, 9g), Zhi Gan Cao (炙甘草, 6g), and Da Zao (大枣, 6–12 pieces). Place all six ingredients in a pot with approximately 2 liters of water (the original text says "one dou"). Bring to a boil, then simmer until the liquid is reduced to about 600ml ("three sheng"). Strain out the dregs and divide into three equal portions to be taken warm throughout the day.

Adding Malt Sugar (Yi Tang)

If the patient is very weak, add 30g of malt sugar (饴糖, Yi Tang) after straining. Return the strained decoction to a gentle flame and stir until the malt sugar fully dissolves. Do not boil vigorously after adding the malt sugar — gentle warming is sufficient. This modified version is functionally equivalent to Xiao Jian Zhong Tang with added Dang Gui.

Common Modifications

How practitioners adapt Dang Gui Jian Zhong Tang for specific situations

Added
Yi Tang

30g, dissolved into the strained decoction while still warm

The original text specifies adding maltose (Yi Tang) when the patient is greatly deficient ('若大虚,加饴糖六两'). Yi Tang's sweet, warming nature powerfully tonifies the Spleen, nourishes the Middle Jiao, and enhances the formula's antispasmodic action.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Dang Gui Jian Zhong Tang should not be used or requires extra caution

Avoid

Damp-Heat patterns (symptoms like bitter taste, yellow greasy tongue coating, foul-smelling stools). This warming, sweet formula will aggravate internal Damp-Heat rather than resolve it.

Avoid

Yin deficiency with vigorous Fire (symptoms like hot flashes, night sweats, dry mouth, red tongue with little coating). The warm nature of the formula can further deplete Yin and fan deficiency Fire.

Avoid

Frequent vomiting (呕家). The classical literature on Jian Zhong formulas states that patients who vomit easily should not use this formula, as its sweet, rich nature can worsen nausea and vomiting.

Avoid

Abdominal fullness and distension due to excess (中满). The sweet, tonifying nature of this formula can worsen bloating and stagnation in patients with excess-type epigastric or abdominal distension.

Caution

Acute febrile illness or external pathogen invasion that has not been resolved. Using a warming tonic formula while an external pathogen is still present can trap the pathogen inside the body.

Caution

Diabetes or significant blood sugar concerns. When malt sugar (Yi Tang) is added to the formula (as is common), it can raise blood sugar. People with diabetes should use this formula with caution and under professional guidance.

Caution

Severe Blood stasis causing acute, fixed, stabbing abdominal pain with refusal to be pressed. While Dang Gui has mild Blood-moving action, this formula is primarily a tonifying formula and is not designed for strong Blood stasis patterns.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. While none of the individual herbs in the standard composition are strongly contraindicated in pregnancy, Gui Zhi (Cinnamomi Ramulus) or Gui Xin (Cinnamomi Cortex) is warm and mildly activating, and Dang Gui (Angelicae Sinensis Radix) has mild Blood-moving properties. Together, these herbs could theoretically stimulate uterine activity if used in large doses or over prolonged periods. Gan Cao (Glycyrrhizae Radix) in this formula may also have mild steroid-like effects and has been associated with increased risk of preterm delivery when consumed in large amounts. The formula was historically designed for postpartum recovery, not for use during pregnancy. Pregnant women should only take this formula under the guidance of a qualified practitioner who can carefully assess the situation.

Breastfeeding

Generally considered safe and potentially beneficial during breastfeeding. This formula was historically designed specifically for postpartum recovery and has been traditionally used in the weeks following childbirth. Its Blood-nourishing and Qi-supplementing actions can support lactation by strengthening the source of Blood and Qi production. The herbs in the standard composition are mild and food-grade in nature (ginger, jujube dates, licorice, cinnamon, peony, angelica root), and no significant concerns about transfer of harmful substances through breast milk have been identified. Classical texts even note that it can be taken regularly in the first month postpartum. However, if the nursing mother has signs of Heat or Damp-Heat, the warming nature of this formula may not be appropriate.

Children

Dang Gui Jian Zhong Tang can be used in children for conditions involving Middle Jiao deficiency-cold with Blood deficiency, such as chronic abdominal pain that improves with warmth and pressure. However, the dosage must be significantly reduced according to the child's age and weight. A general guideline is approximately one-third of the adult dose for children aged 6–12, and one-quarter or less for children under 6. The malt sugar (Yi Tang) component makes the formula naturally palatable for children. This formula should only be used in pediatric patients under the supervision of a qualified practitioner. It is not suitable for children with signs of Damp-Heat, food stagnation, or acute febrile conditions.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Dang Gui Jian Zhong Tang

Gan Cao (Licorice Root) in this formula has well-documented drug interactions due to its glycyrrhizin content, which has mineralocorticoid-like effects:

  • Cardiac glycosides (e.g. digoxin): Gan Cao can promote potassium excretion, leading to low blood potassium levels. This increases the heart's sensitivity to digoxin and may trigger digoxin toxicity and dangerous heart rhythm disturbances. Concurrent use should be avoided.
  • Antihypertensive medications: Gan Cao causes the body to retain salt and water, which can raise blood pressure and counteract the effects of blood pressure-lowering drugs. Blood pressure should be monitored if co-administration is necessary.
  • Potassium-depleting diuretics (e.g. furosemide, hydrochlorothiazide): Combined potassium loss from both the diuretic and Gan Cao may lead to dangerously low potassium levels, causing muscle weakness and heart rhythm problems.
  • Diabetes medications (insulin, sulfonylureas): Gan Cao has cortisol-like activity that can raise blood sugar, potentially counteracting hypoglycemic drugs.
  • Warfarin (anticoagulants): Gan Cao may reduce warfarin's effectiveness, increasing the risk of blood clots. Dang Gui may have mild anticoagulant effects in the opposite direction. Close monitoring of clotting parameters (INR) is advised.
  • Corticosteroids: Gan Cao can slow the breakdown of corticosteroids in the body, raising their blood levels and increasing the risk of side effects such as fluid retention, high blood pressure, and low potassium.

Patients taking any of the above medications should consult both their prescribing physician and their TCM practitioner before using this formula.

Usage Guidance

Practical advice for getting the most out of Dang Gui Jian Zhong Tang

Best time to take

Warm, 30 minutes before meals, divided into 2–3 doses per day.

Typical duration

Often taken for 2–4 weeks for acute postpartum recovery; may be used for 4–8 weeks for chronic deficiency patterns, reassessed by a practitioner.

Dietary advice

Avoid cold and raw foods (such as iced drinks, salads, sashimi, and cold fruit) while taking this formula, as they can damage Spleen Yang and directly counteract its warming, Middle-strengthening action. Also avoid greasy, heavy, or hard-to-digest foods that can burden an already weakened digestive system. Spicy, strongly stimulating foods (hot chili, excessive garlic) should be reduced, as they may irritate the digestive tract and interfere with the formula's gentle, nourishing approach. Favor warm, easily digestible foods such as congee (rice porridge), soft-cooked grains, steamed vegetables, warm soups, and gently cooked meats. These complement the formula's strategy of warming and rebuilding the center.

Dang Gui Jian Zhong Tang originates from Qian Jin Yi Fang (千金翼方, Supplement to the Thousand Gold Prescriptions) by Sun Simiao; originally appeared as Nei Bu Dang Gui Jian Zhong Tang in the Bei Ji Qian Jin Yao Fang (备急千金要方). Tang dynasty, c. 682 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Dang Gui Jian Zhong Tang and its clinical use

From the Qian Jin Yi Fang (千金翼方, Supplement to the Thousand Gold Prescriptions) by Sun Simiao

治产后虚羸不足,腹中疾痛不止,吸吸少气,或若小腹拘急挛痛引腰背,不能饮食,产后一月,日得服四五剂为善,令人强壮内补方。

Translation: "Treats postpartum weakness and deficiency, with incessant aching pain in the abdomen, labored and shallow breathing, or cramping urgency in the lower abdomen with pain pulling into the lower back, and inability to eat. In the first month after delivery, taking four to five doses per day is beneficial. It is a formula for internal supplementation that makes one strong and robust."

From the Jin Gui Yao Lue (金匮要略) — appended formula from Qian Jin

若大虚,加饴糖六两,汤成内之于火上暖,令饴糖消。若去血过多,崩伤内衄不止,加地黄六两,阿胶二两,合八味,汤成内阿胶。若无当归,以芎藭代之。若无生姜,以干姜代之。

Translation: "If there is great deficiency, add six liang of malt sugar. After the decoction is complete, warm it over fire until the malt sugar dissolves. If there is excessive blood loss, or unceasing uterine hemorrhage, add six liang of Rehmannia root and two liang of donkey-hide gelatin, making eight ingredients total, and add the gelatin after straining. If Dang Gui is unavailable, substitute Chuan Xiong. If fresh ginger is unavailable, substitute dry ginger."

Historical Context

How Dang Gui Jian Zhong Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Dang Gui Jian Zhong Tang first appeared under the name "Nei Bu Dang Gui Jian Zhong Tang" (内补当归建中汤, Internal Supplementation Dang Gui Middle-Strengthening Decoction) in Sun Simiao's Bei Ji Qian Jin Yao Fang (备急千金要方, Essential Prescriptions Worth a Thousand Gold), composed during the Tang dynasty. In Sun Simiao's later work, the Qian Jin Yi Fang (千金翼方, Supplement to the Thousand Gold Prescriptions, c. 682 CE), the prefix "Nei Bu" was dropped, and the formula became known simply as "Dang Gui Jian Zhong Tang." It was later appended to the Jin Gui Yao Lue (金匮要略) in the chapter on postpartum diseases, though it is not original to Zhang Zhongjing's text.

The formula belongs to the Jian Zhong ("Middle-Strengthening") family of prescriptions that all derive from the foundational Xiao Jian Zhong Tang (小建中汤). While Xiao Jian Zhong Tang focuses on warming the Middle Jiao and harmonizing the Liver and Spleen, Dang Gui Jian Zhong Tang adds a single herb — Dang Gui — to specifically enhance the Blood-nourishing and pain-relieving capacity of the formula. Classical commentary notes that "Dang Gui Jian Zhong Tang is biased toward harmonizing Blood and stopping pain" (当归建中汤乃偏重于和血止痛). Huang Qi Jian Zhong Tang, the other major variant, instead adds Huang Qi to strengthen Qi supplementation. This formula was included in China's first batch of 100 Classical Famous Formulas (古代经典名方目录), recognizing its enduring clinical importance.

Although originally indicated for postpartum disorders, later physicians expanded its use beyond obstetrics. Historical texts such as the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方) and the San Yin Ji Yi Bing Zheng Fang Lun (三因极一病证方论) both recorded versions of this formula, with slightly varied compositions, for treating Blood deficiency with abdominal pain in both men and women.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Dang Gui Jian Zhong Tang

1

Quality Marker Discovery of Danggui Jianzhong Decoction for Treating Primary Dysmenorrhoea Based on Chinmedomics Strategy (Preclinical, 2023)

Wang Y, Yang L, Zhang X, Sun Y, Sun H, Yan G, Zhao Q, Han Y, Wang X. Phytomedicine. 2023 Jul;115:154724.

This animal study used a metabolomics-based approach ('chinmedomics') to evaluate how Dang Gui Jian Zhong Tang works in a rat model of primary period pain. Researchers identified 29 metabolic markers for period pain that the formula was able to regulate, mainly involving pathways related to arachidonic acid metabolism, fat metabolism, and hormone synthesis. They also identified five key active compounds in the formula (ferulic acid, zizyphusin, cinnamic acid, protocatechuic acid-3-glucoside, and azelaic acid) that appear to be primarily responsible for its pain-relieving effects.

DOI
2

Quality Evaluation of Danggui Jianzhong Decoction Using UHPLC Fingerprint, Chemical Pattern Recognition, and Network Pharmacology (Laboratory, 2022)

Feng Y, Hu J, Wang F, Li B, Qian Q, Wang X, Niu L. Journal of Separation Science. 2022 Oct;45(20):3838-3851.

This laboratory study established a method to evaluate and standardize the quality of Dang Gui Jian Zhong Tang decoctions across different batches. Using advanced chromatography and computer-based network analysis, the researchers identified 19 key chemical components and seven quality markers. Their network pharmacology analysis suggested that the formula's mechanism for treating period pain may be related to regulating inflammatory responses through multiple molecular targets.

DOI
3

Comprehensive Quality Evaluation of Danggui-Jianzhong Decoction by Fingerprint Analysis, Multi-Component Quantitation and UPLC-Q-TOF-MS (Laboratory, 2024)

Huang L, Liu Q, Zhang W, Lin B, Gao Y, Deng H, Zhang S. Journal of Chromatographic Science. 2024 Aug;62(7):635-648.

This analytical chemistry study identified 77 chemical components in Dang Gui Jian Zhong Tang for the first time, including terpenoids, flavonoids, phenolic acids, and gingerols. The researchers developed a reliable method for quality control by quantifying six representative compounds (paeoniflorin, liquiritin, ferulic acid, cinnamic acid, glycyrrhizic acid, and 6-gingerol) across multiple batches, providing a scientific foundation for standardizing this classical formula.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.