Ba Xian Chang Shou Wan

Eight Immortals Longevity Pill · 八仙長壽丸

Also known as: Mai Wei Di Huang Wan (麦味地黄丸), Eight Immortals Pill for Longevity

A classical longevity formula used to nourish and replenish the Kidneys and Lungs. It is commonly used for chronic dry cough, shortness of breath, night sweats, dizziness, tinnitus, and low back soreness caused by depletion of the body's cooling and moistening capacity. Built on the well-known Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill) with the addition of two herbs that specifically support the Lungs.

Origin Shou Shi Bao Yuan (寿世保元), Volume 4, by Gong Tingxian (龚廷贤) — Ming dynasty, 1615 CE
Composition 8 herbs
Shu Di huang
King
Shu Di huang
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Deputy
Shan Yao
Mai Dong
Deputy
Mai Dong
Wu Wei Zi
Deputy
Wu Wei Zi
Fu Ling
Assistant
Fu Ling
Mu Dan Pi
Assistant
Mu Dan Pi
Ze Xie
Assistant
Ze Xie
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ba Xian Chang Shou Wan is designed to correct these specific patterns.

Why Ba Xian Chang Shou Wan addresses this pattern

When the Kidneys fail to nourish the Lungs (the "metal-water" generating relationship), both organs become depleted of Yin. The Kidneys lose their ability to grasp Qi descending from the Lungs, while the Lungs lose their moisture and cooling capacity. This produces a combination of lower body signs (low back soreness, weak knees, tinnitus) and upper body signs (dry cough, dry throat, shortness of breath). Ba Xian Chang Shou Wan addresses the root (Kidney Yin) with Shu Di Huang, Shan Zhu Yu, and Ze Xie, while directly replenishing the branch (Lung Yin) with Mai Dong and Wu Wei Zi. Shan Yao bridges both organ systems, tonifying the Spleen to support postnatal production while also benefiting the Lungs.

A practitioner would look for one or more of these signs

Dry Cough

Worse in the evening, with little or no phlegm

Night Sweats

Especially after midnight

Tinnitus

Persistent ringing in the ears

Dry Throat

With thirst and desire for small sips

Lower Back Pain

Dull, chronic soreness in the lumbar region

Shortness Of Breath

Worsened by physical exertion

Menopausal Hot Flashes

Tidal heat, especially in the afternoon

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ba Xian Chang Shou Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, diabetes is understood as "wasting-thirst" (xiao ke), a condition rooted in Yin deficiency and internal dryness. The Lungs govern the upper portion of fluid distribution, the Stomach the middle, and the Kidneys the lower. When Lung Yin is depleted, there is excessive thirst and dry mouth (upper wasting-thirst). When Kidney Yin is exhausted, there is frequent and copious urination (lower wasting-thirst). Because the Kidneys are the root of all Yin in the body, Kidney Yin deficiency often underlies all three types. Prolonged deficiency Heat from Yin depletion further scorches fluids, creating a self-reinforcing cycle of dryness.

Why Ba Xian Chang Shou Wan Helps

Ba Xian Chang Shou Wan addresses the root Kidney Yin deficiency with Shu Di Huang and Shan Zhu Yu while also replenishing Lung and Stomach Yin through Mai Dong and Shan Yao. Wu Wei Zi astringes fluids to reduce excessive fluid loss. This combination targets the upper and lower wasting-thirst presentations simultaneously. Modern pharmacological research has found that several of its ingredients, including Shan Yao and Shu Di Huang, may support healthy blood sugar metabolism.

Also commonly used for

Asthma

Yin-deficient wheezing with dyspnea on exertion

Pulmonary Tuberculosis

Adjunctive use for Yin-depleting consumption

Night Sweats

From Yin deficiency with deficiency Heat

Chronic Obstructive Pulmonary Disease

Stable phase with Yin deficiency pattern

Chronic Bronchitis

With dry cough and Yin depletion

Chronic Nephritis

With Kidney Yin deficiency signs

Tinnitus

From Kidney Yin deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ba Xian Chang Shou Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ba Xian Chang Shou Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ba Xian Chang Shou Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ba Xian Chang Shou Wan works at the root level.

This formula addresses a pattern where the Yin of both the Kidneys and the Lungs has become depleted. In TCM theory, the Kidneys are the root of Yin for the entire body, and the Lungs depend on the Kidneys to "grasp" Qi and receive nourishing fluids from below. When Kidney Yin runs low, it fails to send moisture upward to nourish the Lungs. Simultaneously, the Lungs (which govern the downward distribution of fluids) cannot properly moisten the Kidneys in return. This creates a vicious cycle of drying out in both organs.

As Yin declines, the body loses its cooling, moistening counterbalance. Deficiency Heat arises: tidal fevers that worsen in the afternoon, night sweats as the body tries to vent trapped warmth, a dry and sore throat from lack of fluid, and a dry cough that worsens in the evening. The Kidneys, deprived of Essence, produce symptoms like dizziness, tinnitus, diminished hearing, sore lower back and knees, and scanty urine. Because Yin is the substance that anchors Yang, its deficiency allows empty Heat to float upward, creating a hot, dry upper body while the root (Kidneys) remains depleted below.

This pattern is commonly seen in older adults whose Yin naturally declines with age, in people recovering from chronic illness or prolonged fever, in menopausal women experiencing hot flashes, and historically in conditions like pulmonary tuberculosis or diabetes (known in TCM as "wasting-thirst" or Xiao Ke). The formula works by replenishing the Yin of both Lungs and Kidneys simultaneously, anchoring the rising deficiency Heat, and preventing further leakage of precious fluids.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and sour with mild bitter notes. Sweet to nourish and tonify Yin, sour to astringe and contain leaking fluids and Essence, bitter to gently clear deficiency Heat.

Channels Entered

Kidney Lung Liver Spleen

Ingredients

8 herbs

The herbs that make up Ba Xian Chang Shou Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 24 - 32g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Ba Xian Chang Shou Wan

Strongly enriches Kidney Yin and nourishes the Blood and Essence. As the heaviest herb by dose, it anchors the formula's core strategy of replenishing the depleted Yin foundation of the Kidneys.
Deputies — Assists and enhances the King
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 12 - 16g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver

Role in Ba Xian Chang Shou Wan

Nourishes the Liver and Kidneys, restrains the leakage of Essence, and astringes to prevent further loss of Yin fluids. Works with Shu Di Huang to stabilize Kidney Yin from both a nourishing and consolidating angle.
Shan Yao

Shan Yao

Yam

Dosage 12 - 16g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Ba Xian Chang Shou Wan

Tonifies the Spleen and Lung Qi, stabilizes the Kidneys, and binds the Essence. Strengthens the Spleen as the source of postnatal Essence to support the Kidney replenishment strategy.
Mai Dong

Mai Dong

Dwarf lilyturf roots

Dosage 9 - 12g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Stomach

Role in Ba Xian Chang Shou Wan

Nourishes Lung and Stomach Yin, generates fluids, and clears Heat from the Heart. This is one of the two herbs added to the Liu Wei Di Huang Wan base, directly addressing the Lung Yin deficiency component of the pattern.
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 6 - 9g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Ba Xian Chang Shou Wan

Astringes the Lung Qi, restrains Kidney Essence, and generates fluids. The second herb added to the Liu Wei Di Huang Wan base, it prevents further dissipation of Lung Qi and Yin through its sour, astringing action.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Ba Xian Chang Shou Wan

Leaches Dampness, strengthens the Spleen, and calms the Spirit. Assists Shan Yao in supporting Spleen function and prevents the rich, cloying tonic herbs from generating Dampness or stagnation.
Mu Dan Pi

Mu Dan Pi

Mudan peony bark

Dosage 9 - 12g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Kidneys, Liver

Role in Ba Xian Chang Shou Wan

Clears deficiency Heat, cools the Blood, and invigorates Blood circulation. Addresses the Heat generated by Yin deficiency and prevents Blood stasis, while restraining Shan Zhu Yu from being too astringing.
Ze Xie

Ze Xie

Water plantain

Dosage 9 - 12g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Ba Xian Chang Shou Wan

Promotes urination and drains turbid Dampness from the Kidneys. Balances the formula's heavily tonifying nature by clearing Dampness, preventing stagnation, and directing pathological fluids downward and out.

Why This Combination Works

How the herbs in Ba Xian Chang Shou Wan complement each other

Overall strategy

This formula addresses the simultaneous depletion of Kidney and Lung Yin by combining the classical "three tonifying, three draining" structure of Liu Wei Di Huang Wan with two additional herbs that specifically nourish and consolidate the Lungs. The design ensures that Yin is replenished at its root (the Kidneys) while also being preserved where it is actively being lost (the Lungs).

King herb

Shu Di Huang (prepared Rehmannia) serves as the King at the heaviest dosage. It is sweet, slightly warm, and enters the Kidney and Liver channels, making it the strongest Yin- and Blood-nourishing herb in the formula. It directly fills the depleted Kidney Yin and Essence that form the root of the pattern.

Deputy herbs

Shan Zhu Yu nourishes the Liver and Kidneys and astringes Essence, preventing further leakage. Shan Yao tonifies the Spleen and Lungs and stabilizes the Kidneys, reinforcing postnatal Essence production. Mai Dong (Ophiopogon) nourishes Lung and Stomach Yin, generates fluids, and gently clears Heart Heat, directly addressing the dry cough and dry throat that characterize the Lung Yin deficiency. Wu Wei Zi (Schisandra) astringes Lung Qi and restrains Kidney Essence with its sour taste, preventing further dissipation of Yin fluids through chronic cough and sweating.

Assistant herbs

Fu Ling (reinforcing assistant) strengthens the Spleen and leaches Dampness, preventing the heavy tonic herbs from clogging digestion. Mu Dan Pi (restraining assistant) clears deficiency Heat and cools the Blood, addressing the low-grade fever and night sweats from Yin deficiency Fire, while preventing the astringing herbs from trapping pathological Heat. Ze Xie (restraining assistant) drains turbid Dampness downward through urination, counterbalancing the richness of Shu Di Huang and keeping pathological fluids from accumulating.

Notable synergies

The Mai Dong and Wu Wei Zi pairing is central to this formula's distinction from Liu Wei Di Huang Wan: Mai Dong moistens and nourishes the Lung while Wu Wei Zi astringes and consolidates it, together forming a "nourish and contain" strategy for Lung Yin. The classical "three tonifying, three draining" structure (Shu Di Huang/Shan Zhu Yu/Shan Yao tonify; Ze Xie/Mu Dan Pi/Fu Ling drain) ensures that replenishment does not create stagnation.

How to Prepare

Traditional preparation instructions for Ba Xian Chang Shou Wan

Grind all eight herbs into a fine powder. Mix with refined honey to form pills the size of Chinese parasol tree seeds (approximately 3-4mm in diameter). Take 9g per dose on an empty stomach, swallowed with warm ginger decoction, once or twice daily.

In modern practice, this formula is widely available as concentrated pills (teapills), water-honey pills, or large honey pills. Standard modern dosage is 8 teapills three times daily, or one large honey pill (9g) twice daily.

Common Modifications

How practitioners adapt Ba Xian Chang Shou Wan for specific situations

Added
Bai He

9-15g, moistens the Lung and stops cough

E Jiao

6-9g, dissolved separately (烊化), nourishes Yin and stops bleeding

Bai He reinforces Lung Yin nourishment while E Jiao directly addresses the Blood-level depletion and stops hemoptysis by nourishing Blood and Yin.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ba Xian Chang Shou Wan should not be used or requires extra caution

Avoid

External pathogenic conditions such as colds and flu. The rich, Yin-nourishing nature of this formula can trap pathogens inside the body and worsen acute infections.

Avoid

Internal Cold patterns or Yang deficiency. This formula is cooling in nature and will further damage Yang if used when cold signs predominate (cold limbs, pale tongue, watery stools).

Caution

Spleen deficiency with significant Dampness or phlegm. The cloying, Yin-enriching herbs (especially Shu Di Huang) can worsen Dampness, bloating, and poor digestion.

Caution

Yin deficiency with vigorous Fire and concurrent Dampness. In such cases, formulas with stronger Heat-clearing capacity (such as Zhi Bai Di Huang Wan) may be more appropriate.

Caution

Patients with loose stools or poor appetite due to Spleen Qi deficiency. The heavy, moistening ingredients may further burden the digestive system.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Official Chinese pharmaceutical labeling states that pregnant women should take this formula only under the guidance of a qualified practitioner. While none of the eight ingredients are classified as strongly abortifacient or uterine-stimulating, Mu Dan Pi (Tree Peony Root Bark) has mild Blood-moving properties and is traditionally used with caution during pregnancy. Ze Xie (Water Plantain) is a diuretic that could theoretically affect fluid balance. The rich, cloying nature of Shu Di Huang may also exacerbate the nausea and digestive sluggishness common in pregnancy. Overall, this is not an absolutely contraindicated formula in pregnancy, but it should not be self-prescribed and requires professional supervision.

Breastfeeding

No specific contraindication during breastfeeding has been established for this formula. The Chinese pharmaceutical labeling for Mai Wei Di Huang Wan advises that breastfeeding women should use it under the guidance of a qualified practitioner. The ingredients are generally mild, nourishing herbs without known toxicity concerns for nursing infants. Shu Di Huang is a rich, heavy herb that could theoretically contribute to digestive issues in sensitive nursing mothers, which might affect milk quality. Fu Ling and Ze Xie have diuretic properties that could theoretically affect fluid balance and milk production, though this has not been clinically documented. Overall, this formula is considered relatively safe during breastfeeding with professional guidance.

Children

Chinese pharmaceutical labeling for Mai Wei Di Huang Wan states that children must use this formula under adult supervision and with practitioner guidance. This formula was not originally designed for pediatric use; its parent formula Liu Wei Di Huang Wan was originally a pediatric remedy (by Qian Yi), but Ba Xian Chang Shou Wan was developed specifically for elderly patients with Lung-Kidney Yin depletion. Children generally have robust Yang and rarely present with the deep Yin deficiency pattern this formula addresses. If prescribed for older children or adolescents with confirmed Lung-Kidney Yin deficiency, the dosage should typically be reduced to one-third to one-half of the adult dose depending on the child's age, weight, and constitution. Not recommended for infants or very young children without specific practitioner guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ba Xian Chang Shou Wan

Shu Di Huang (Prepared Rehmannia) has been shown in pharmacological studies to affect cytochrome P450 enzyme activity. Research on the parent formula Liu Wei Di Huang Wan demonstrated that it can induce CYP1A2 while suppressing CYP2A6 and N-acetyltransferase 2 (NAT2) activity, which could alter the metabolism of drugs processed through these pathways. Medications metabolized by CYP1A2 (such as theophylline, caffeine, and certain antipsychotics) may have reduced blood levels, while medications affected by CYP2A6 or NAT2 suppression could accumulate.

Ze Xie (Water Plantain) has diuretic properties and may potentiate the effects of pharmaceutical diuretics, potentially leading to excessive fluid loss or electrolyte imbalances when combined with thiazide or loop diuretics.

Shan Zhu Yu (Cornus fruit) may have mild hypoglycemic effects, and the formula as a whole has been studied in the context of diabetes management. Patients taking insulin or oral hypoglycemic agents should monitor blood sugar closely, as additive blood sugar-lowering effects are theoretically possible.

Wu Wei Zi (Schisandra) is known to affect hepatic drug metabolism and may interact with medications processed through the liver. It has documented effects on various CYP450 enzymes.

As with all herbal formulas, patients taking anticoagulants should exercise caution due to the mild Blood-moving action of Mu Dan Pi (Tree Peony Bark).

Usage Guidance

Practical advice for getting the most out of Ba Xian Chang Shou Wan

Best time to take

Traditionally taken on an empty stomach with warm water or lightly salted warm water, typically twice daily (morning and evening) about 30 minutes before meals.

Typical duration

Typically taken for 4-8 weeks as a course of treatment, then reassessed. As a longevity and constitution-nourishing formula for elderly patients, it may be taken intermittently over longer periods under practitioner supervision.

Dietary advice

Avoid greasy, oily, and heavily fried foods, which can burden the Spleen and interfere with the absorption of the formula's rich, Yin-nourishing herbs. Avoid hard-to-digest foods for the same reason. Avoid spicy, hot, and pungent foods (chili peppers, raw garlic, strong alcohol, lamb) that can aggravate deficiency Heat and further damage Yin. Favor foods that nourish Yin and generate fluids: pears, white fungus (yin er/tremella), lily bulb, lotus seed, black sesame, honey, duck, tofu, and congee. Mildly cooling fruits and lightly prepared vegetables support the formula's moistening action. Stay well hydrated but avoid ice-cold beverages, which can impair Spleen function and obstruct fluid metabolism.

Ba Xian Chang Shou Wan originates from Shou Shi Bao Yuan (寿世保元), Volume 4, by Gong Tingxian (龚廷贤) Ming dynasty, 1615 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ba Xian Chang Shou Wan and its clinical use

《寿世保元》(Shòu Shì Bǎo Yuán) by Gōng Tíng-Xián:
This is the source text for Ba Xian Chang Shou Wan. The formula is presented as a modification of Liu Wei Di Huang Wan (Six-Ingredient Pill with Rehmannia) with the addition of Mai Men Dong (Ophiopogon) and Wu Wei Zi (Schisandra), intended for the treatment of Lung and Kidney Yin deficiency with symptoms including tidal fever, night sweats, dry throat, dizziness, tinnitus, and aching lower back and knees.

《医方集解》(Yī Fāng Jí Jiě) by Wāng Áng:
The formula is also referenced in this important Qing dynasty formula commentary, which categorizes it among Yin-supplementing prescriptions and explains how the addition of Ophiopogon and Schisandra to the base six-ingredient formula specifically addresses Lung Yin insufficiency alongside Kidney Yin depletion.

Historical Context

How Ba Xian Chang Shou Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Origin and naming: Ba Xian Chang Shou Wan ("Eight Immortals Longevity Pill") was first recorded in the Shou Shi Bao Yuan (《寿世保元》, "Longevity and Life Preservation"), written by the Ming dynasty physician Gong Tingxian (龚廷贤) and completed in 1615. The evocative name references the Eight Immortals (八仙) of Chinese mythology, suggesting that taking this pill could promote the kind of longevity enjoyed by these legendary figures. The "eight" also refers to the eight medicinal ingredients. The formula is equally well known by its more clinical name, Mai Wei Di Huang Wan (麦味地黄丸, "Ophiopogon and Schisandra Rehmannia Pill").

Gong Tingxian was one of the most celebrated physicians of the Ming dynasty, honored with the title "Champion of the Medical Forest" (医林状元) by the Prince of Lu after he saved the prince's consort from a life-threatening illness. He served in the Imperial Medical Academy and practiced for over 60 years, living past the age of 90. His works, particularly the Shou Shi Bao Yuan and Wan Bing Hui Chun, spread throughout East Asia and were reprinted dozens of times, including in Japan.

Evolution: The formula is a direct descendant of Liu Wei Di Huang Wan, the foundational Yin-nourishing formula created by the Song dynasty pediatrician Qian Yi (钱乙), which in turn was derived from Zhang Zhongjing's Shen Qi Wan by removing the warming herbs Gui Zhi and Fu Zi. By adding Mai Men Dong and Wu Wei Zi, Gong Tingxian specifically extended the formula's reach from the Kidneys upward to the Lungs, making it particularly suited for elderly patients with Lung-Kidney Yin depletion. Some modern manufacturers (notably Golden Flower Chinese Herbs) produce an expanded version that adds Bei Sha Shen, Yu Zhu, and Shi Hu for even stronger Yin-nourishing and fluid-generating effects, and substitutes Sheng Di Huang for Shu Di Huang to increase the cooling action.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Ba Xian Chang Shou Wan

1

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Ba Wei Di Huang Wan in the Treatment of Dementia (RCT, 2004)

Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Cho S, Akiba T, Arai H, Cyong JC, Sasaki H. Journal of the American Geriatrics Society, 2004, 52(9), 1518-1521.

This small RCT conducted in a Japanese long-term care facility enrolled 33 elderly patients with dementia. Participants receiving the formula (which is closely related to Ba Xian Chang Shou Wan) for 8 weeks showed statistically significant improvement in cognitive function as measured by the Mini-Mental State Examination (MMSE), improving from 13.5 to 16.3. The placebo group did not show similar improvement. Note: This study used Ba Wei Di Huang Wan (the Jin Gui Shen Qi Wan variant), not the exact Mai Wei Di Huang Wan formulation, but the studies share the Liu Wei Di Huang Wan base.

2

Meta-Analysis of Liuwei Dihuang Wan Categorized Formulas in Treating Diabetic Nephropathy Proteinuria (Meta-analysis, 2018)

Published in Evidence-Based Complementary and Alternative Medicine, 2018 (PMC6178512).

This meta-analysis examined 14 RCTs involving 918 patients with diabetic nephropathy who received formulas from the Liu Wei Di Huang Wan family (including Mai Wei Di Huang Wan). Results showed that adding these formulas to standard treatment significantly improved overall clinical efficacy and reduced 24-hour urinary protein levels and urine microalbumin excretion rate compared to standard treatment alone. No serious adverse reactions were reported.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.